α:β Selectivity in the synthesis of 3-substituted, 4-methyl umbelliferone glycosides of N-acetyl glucosamine and chitobiose Fulltext Access 14 Pages 2005
α-cycloalkyl-substituted Ï-keto-dicarboxylic acids as lipid regulating agents Fulltext Access 14 Pages 2005
Diphenylcyclohexylamine derivatives as new potent multidrug resistance (MDR) modulators Fulltext Access 14 Pages 2005
Hantzsch 1,4-dihydropyridines containing a diazen-1-ium-1,2-diolate nitric oxide donor moiety to study calcium channel antagonist structure-activity relationships and nitric oxide release Fulltext Access 14 Pages 2005
Synthesis and pharmacological evaluation of side chain modified glutamic acid analogues of the neuroprotective agent glycyl-l-prolyl-l-glutamic acid (GPE) Fulltext Access 14 Pages 2005
Selective inhibitors of GABA uptake: synthesis and molecular pharmacology of 4-N-methylamino-4,5,6,7-tetrahydrobenzo[d]isoxazol-3-ol analogues Fulltext Access 14 Pages 2005
Discovery of 1,7-cyclized indoles as a new class of potent and highly selective human β3-adrenergic receptor agonists with high cell permeability Fulltext Access 14 Pages 2005
Synthesis of 13C-labeled γ-hydroxybutyrates for EPR studies with 4-hydroxybutyryl-CoA dehydratase Fulltext Access 14 Pages 2005
Synthesis of structural variants of Staphylococcus aureus lipoteichoic acid (LTA) Fulltext Access 14 Pages 2005
Potent antitumor 9-anilinoacridines bearing an alkylating N-mustard residue on the anilino ring: synthesis and biological activity Fulltext Access 14 Pages 2005
Peak Height Precision in Hadamard Transform Time-of-Flight Mass Spectra Fulltext Access 14 Pages 2005
Computational Investigation and Hydrogen/Deuterium Exchange of the Fixed Charge Derivative Tris(2,4,6-Trimethoxyphenyl) Phosphonium: Implications for the Aspartic Acid Cleavage Mechanism Fulltext Access 14 Pages 2005
Generation and Characterization of Ionic and Neutral [HS-P-OH]+/· and S=P(OH)2+/· in the Gas Phase by Tandem Mass Spectrometry and Computational Chemistry Fulltext Access 14 Pages 2005
Intriguing Mass Spectrometric Behavior of Guanosine Under Low Energy Collision-Induced Dissociation: H2O Adduct Formation and Gas-Phase Reactions in the Collision Cell Fulltext Access 14 Pages 2005
Multidimensional Protein Identification Technology (MudPIT): Technical Overview of a Profiling Method Optimized for the Comprehensive Proteomic Investigation of Normal and Diseased Heart Tissue Fulltext Access 14 Pages 2005
Protonated Adenine: Tautomers, Solvated Clusters, and Dissociation Mechanisms Fulltext Access 14 Pages 2005
Comparison of experimental and calculated peak shapes for three cylindrical geometry FAIMS prototypes of differing electrode diameters Fulltext Access 14 Pages 2005
Design, synthesis and in vitro cytotoxic studies of novel bis-pyrrolo[2,1][1,4] benzodiazepine-pyrrole and imidazole polyamide conjugates Fulltext Access 14 Pages 2005
Adrenomedullin: a new target for the design of small molecule modulators with promising pharmacological activities Fulltext Access 14 Pages 2005
Synthesis and SAR/3D-QSAR studies on the COX-2 inhibitory activity of 1,5-diarylpyrazoles to validate the modified pharmacophore Fulltext Access 14 Pages 2005
Synthesis and inhibitory activity of benzoic acid and pyridine derivatives on influenza neuraminidase Fulltext Access 14 Pages 2005
Terpene trilactones from Gingko biloba: From ancient times to the 21st century Fulltext Access 14 Pages 2005
Nuclear receptor antagonists designed based on the helix-folding inhibition hypothesis Fulltext Access 14 Pages 2005
Substrate specificity of the bovine serum amine oxidase and in situ characterisation of aminoaldehydes by NMR spectroscopy Fulltext Access 14 Pages 2005
1-Substituted pyrazolo[1,5-c]quinazolines as novel Gly/NMDA receptor antagonists: Synthesis, biological evaluation, and molecular modeling study Fulltext Access 14 Pages 2005
Insight into 2-phenylpyrazolo[1,5-a]pyrimidin-3-yl acetamides as peripheral benzodiazepine receptor ligands: Synthesis, biological evaluation and 3D-QSAR investigation Fulltext Access 14 Pages 2005
Synthesis and pharmacological evaluation of benzamide derivatives as selective 5-HT4 receptor agonists Fulltext Access 14 Pages 2005
Synthesis of potent and selective inhibitors of Candida albicans N-myristoyltransferase based on the benzothiazole structure Fulltext Access 14 Pages 2005
Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites Fulltext Access 14 Pages 2005
Lysine–spermine conjugates: hydrophobic polyamine amides as potent lipopolysaccharide sequestrants Fulltext Access 14 Pages 2005
QSAR modeling of blood:air and tissue:air partition coefficients using theoretical descriptors Fulltext Access 14 Pages 2005
Structure based design of 4-(3-aminomethylphenyl)piperidinyl-1-amides: novel, potent, selective, and orally bioavailable inhibitors of βII tryptase Fulltext Access 14 Pages 2005
Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers Fulltext Access 14 Pages 2005
Selective anti-tubercular purines: Synthesis and chemotherapeutic properties of 6-aryl- and 6-heteroaryl-9-benzylpurines Fulltext Access 14 Pages 2005
A new type of ketolides bearing an N-aryl-alkyl acetamide moiety at the C-9 iminoether synthesis and structure–activity relationships Fulltext Access 14 Pages 2005
Mechanism and structure–activity relationships of norspermidine-based peptidic inhibitors of trypanothione reductase Fulltext Access 14 Pages 2005
Structure–affinity relationship studies of non-competitive NMDA receptor antagonists derived from dexoxadrol and etoxadrol Fulltext Access 14 Pages 2005
Imaging β-amyloid fibrils in Alzheimer's disease: a critical analysis through simulation of amyloid fibril polymerization Fulltext Access 15 Pages 2005
Protease-mediated enzymatic hydrolysis and activation of aryl phosphoramidate derivatives of stavudine Fulltext Access 15 Pages 2005
A role for the anandamide membrane transporter in TRPV1-mediated neurosecretion from trigeminal sensory neurons Fulltext Access 15 Pages 2005
Structure-activity relationships of novel P2-receptor antagonists structurally related to Reactive Blue 2 Fulltext Access 15 Pages 2005
Pharmacological and pharmacokinetic characterization of the cannabinoid receptor 2 agonist, GW405833, utilizing rodent models of acute and chronic pain, anxiety, ataxia and catalepsy Fulltext Access 15 Pages 2005
Specific neurodevelopmental damage in mice offspring following maternal inflammation during pregnancy Fulltext Access 15 Pages 2005
The preferential mGlu2/3 receptor antagonist, LY341495, reduces the frequency of spike-wave discharges in the WAG/Rij rat model of absence epilepsy Fulltext Access 15 Pages 2005
Imaging mass spectrometry: fundamentals and applications to drug discovery Fulltext Access 15 Pages 2005
Development of a prostaglandin D2 receptor antagonist: discovery of a new chemical lead Fulltext Access 15 Pages 2005
Keynote review: Histamine H3 receptor antagonists reach out for the clinic Fulltext Access 15 Pages 2005
Transfer of lipophilic drugs between liposomal membranes and biological interfaces: Consequences for drug delivery Fulltext Access 15 Pages 2005
N-Acyl-N-alkyl-sulfonamide anchors derived from Kenner's safety-catch linker: powerful tools in bioorganic and medicinal chemistry Fulltext Access 15 Pages 2005
Concise syntheses of arabinogalactans with β-(1â6)-linked galactopyranose backbones and α-(1â3)- and α-(1â2)-linked arabinofuranose side chains Fulltext Access 15 Pages 2005
Stereoselective synthesis of E-64 and related cysteine proteases inhibitors from 2,3-epoxyamides Fulltext Access 15 Pages 2005
Synthesis and cytotoxic activity of carboxamide derivatives of benzo[b][1,6]naphthyridin-(5H)ones Fulltext Access 15 Pages 2005
Large-scale genome clustering across life based on a linguistic approach Fulltext Access 15 Pages 2005
Differential regulation of proteins by bursting calcium oscillations-a theoretical study Fulltext Access 15 Pages 2005
Non-biaryl atropisomers derived from carbohydrates. Part 4: Absolute stereochemistry of carbohydrate-based imidazolidine-2-ones and 2-thiones with axial and central chirality Fulltext Access 15 Pages 2005
Direct and stereoselective synthesis of β-d-mannosides using 4,6-O-benzylidene-protected mannosyl diethyl phosphite as a donor Fulltext Access 15 Pages 2005
Î3-Aryl/heteroaryl substituted heterocycles via sequential Pd-catalysed termolecular cascade/ring closing metathesis (RCM) Fulltext Access 15 Pages 2005
Direct alkenylation of arylamines at the ortho-position with magnesium alkylidene carbenoids and some theoretical studies of the reactions Fulltext Access 15 Pages 2005
Design and synthesis of a new polymer-supported Evans-type oxazolidinone: an efficient chiral auxiliary in the solid-phase asymmetric alkylation reactions Fulltext Access 15 Pages 2005
Absolute stereochemistries and total synthesis of (+)/(â)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion Fulltext Access 15 Pages 2005
Correlation between pressure and steric interactions in organic reactions Fulltext Access 15 Pages 2005
Highly chemoselective hydrogenation method using novel finely dispersed palladium catalyst on silk-fibroin: its preparation and activity Fulltext Access 15 Pages 2005
Directing-protecting groups for carbohydrates. Design, conformational study, synthesis and application to regioselective functionalization Fulltext Access 15 Pages 2005
Remote steric effect on the regioselectivity of Sharpless asymmetric dihydroxylation Fulltext Access 15 Pages 2005
Palladium-catalyzed phosphorus-carbon bond formation: cross-coupling reactions of alkyl phosphinates with aryl, heteroaryl, alkenyl, benzylic, and allylic halides and triflates Fulltext Access 15 Pages 2005
Palladium-catalyzed sequential alkylation-alkenylation reactions: application towards the synthesis of polyfunctionalized fused aromatic rings Fulltext Access 15 Pages 2005
Sulfur dioxide mediated one-pot, four-component synthesis of polyfunctional sulfones and sulfonamides, including medium-ring cyclic derivatives Fulltext Access 15 Pages 2005
Biophysical signatures of noncovalent aggregates formed by a glucagonlike peptide-1 analog: A prototypical example of biopharmaceutical aggregation Fulltext Access 15 Pages 2005
Partial least square projections to latent structures analysis (PLS) in evaluating and predicting drug release from starch acetate matrix tablets Fulltext Access 15 Pages 2005
Supercritical fluid crystallization of griseofulvin: crystal habit modification with a selective growth inhibitor Fulltext Access 15 Pages 2005
Quantitation of crystalline and amorphous forms of anhydrous neotame using 13C CPMAS NMR spectroscopy Fulltext Access 15 Pages 2005
Biophysical Characterization of Insoluble Aggregates of a Multi-Domain Protein: An Insight into the Role of the Various Domains Fulltext Access 15 Pages 2005
A Molecular Functional Study on the Interactions of Drugs with Plasma Proteins Fulltext Access 15 Pages 2005
Alzheimer's disease and the 'ABSENT' hypothesis: mechanism for amyloid β endothelial and neuronal toxicity Fulltext Access 15 Pages 2005
Pressor and intra-renal effects of angiotensins I and II, and noradrenaline, in anaesthetized and conscious sheep Fulltext Access 15 Pages 2005
Correlation Between Epithelial Toxicity and Surfactant Structure as Derived From the Effects of Polyethyleneoxide Surfactants on Caco-2 Cell Monolayers and Pig Nasal Mucosa Fulltext Access 15 Pages 2005
Optimization and Characterization of a Sphingomyelin/Cholesterol Liposome Formulation of Vinorelbine with Promising Antitumor Activity Fulltext Access 15 Pages 2005
Studies on the Crystallinity of a Pharmaceutical Development Drug Substance Fulltext Access 15 Pages 2005
Effects of Benzyl Alcohol on Aggregation of Recombinant Human Interleukin-1-Receptor Antagonist in Reconstituted Lyophilized Formulations Fulltext Access 15 Pages 2005
Cellular Interactions and In Vitro DNA Transfection Studies with Poly(ethylene glycol)âModified Gelatin Nanoparticles Fulltext Access 15 Pages 2005
Neuroprotective effects of novel small peptides in vitro and after brain injury Fulltext Access 15 Pages 2005
Les systèmes colloïdaux de délivrance de médicaments ont-ils aidé à répondre aux espérances thérapeutiques des découvertes de biotechnologie ? Fulltext Access 15 Pages 2005
New synthetic approach to substituted isoindolo[2,1-a]quinoline carboxylic acids via intramolecular Diels-Alder reaction of 4-(N-furyl-2)-4-arylaminobutenes-1 with maleic anhydride Fulltext Access 15 Pages 2005
Highly functionalised organolithium and organoboron reagents for the preparation of enantiomerically pure α-amino acids Fulltext Access 15 Pages 2005
Asymmetric synthesis of 3-substituted 3,4-dihydroisocoumarins via stereoselective addition of laterally lithiated chiral 2-(o-tolyl)oxazolines to aldehydes followed by diastereomer-selective lactonization Fulltext Access 15 Pages 2005
Reductive ring opening of dihydrodibenzothiepine and dihydrodinaphtho-oxepine and -thiepine Fulltext Access 15 Pages 2005