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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

The synthesis of tamoxifen-loaded albumin nanoparticles by homogenizers: Optimization and in vitro characterization
Fulltext Access 11 Pages 2017
Mechanistic aspects of alkene oxidation using chiral hypervalent iodine reagents
Fulltext Access 11 Pages 2017
Reaction of 3-chloroquinoline-2,4-diones with ethanolamine and rearrangement of the reaction products
Fulltext Access 11 Pages 2017
Symmetrical and unsymmetrical incorporation of active biological monomers on the surface of phosphorus dendrimers
Fulltext Access 11 Pages 2017
Interaction of polyfluorinated 2-chloroquinolines with ammonia
Fulltext Access 11 Pages 2017
Palladium-catalysed α-allylation of chiral sulfinimines derived from symmetric cyclic ketones
Fulltext Access 11 Pages 2017
Nanotechnology-based strategies for treatment of ocular disease
Fulltext Access 11 Pages 2017
Class I phosphatidylinositol 3-kinase inhibitors for cancer therapy
Fulltext Access 11 Pages 2017
Discovery of novel multi-target indole-based derivatives as potent and selective inhibitors of chikungunya virus replication
Fulltext Access 11 Pages 2017
Preformulation investigation and challenges; salt formation, salt disproportionation and hepatic recirculation
Fulltext Access 11 Pages 2017
Synthesis and cytotoxic activity of new artemisinin hybrid molecules against human leukemia cells
Fulltext Access 11 Pages 2017
Importance of reversed-phase chromatographic parameters in predicting biopharmaceutical and pharmacokinetic descriptors on the group of androgen derivatives
Fulltext Access 11 Pages 2017
Structural evidence of quercetin multi-target bioactivity: A reverse virtual screening strategy
Fulltext Access 11 Pages 2017
Melt extrusion vs. spray drying: The effect of processing methods on crystalline content of naproxen-povidone formulations
Fulltext Access 11 Pages 2017
Optimization of magnetic retention in the gastrointestinal tract: Enhanced bioavailability of poorly permeable drug
Fulltext Access 11 Pages 2017
An isocyanide based multi-component reaction under catalyst- and solvent-free conditions for the synthesis of unsymmetrical thioureas
Fulltext Access 11 Pages 2017
Infant acetylcholine, dopamine, and melatonin dysregulation: Neonatal biomarkers and causal factors for ASD and ADHD phenotypes
Fulltext Access 11 Pages 2017
Tumors arise from the excessive repair of damaged stem cells
Fulltext Access 11 Pages 2017
Increasing adult hippocampal neurogenesis in mice after exposure to unpredictable chronic mild stress may counteract some of the effects of stress
Fulltext Access 11 Pages 2017
New vistas on cannabis use disorder
Fulltext Access 11 Pages 2017
The endocannabinoid system as a target for addiction treatment: Trials and tribulations
Fulltext Access 11 Pages 2017
A study of time- and sex-dependent effects of vortioxetine on rat sexual behavior: Possible roles of direct receptor modulation
Fulltext Access 11 Pages 2017
Synthesis and cytotoxic activities of goniothalamins and derivatives
Fulltext Access 11 Pages 2017
Potent anti-melanogenic activity and favorable toxicity profile of selected 4-phenyl hydroxycoumarins in the zebrafish model and the computational molecular modeling studies
Fulltext Access 11 Pages 2017
Differences in the coronal proteome acquired by particles depositing in the lungs of asthmatic versus healthy humans
Fulltext Access 11 Pages 2017
Post onset, oral rapamycin treatment delays development of mitochondrial encephalopathy only at supramaximal doses
Fulltext Access 11 Pages 2017
Enduring attenuation of norepinephrine synaptic availability and augmentation of the pharmacological and behavioral effects of desipramine by repeated immobilization stress
Fulltext Access 11 Pages 2017
Preclinical development of moxidectin as a novel therapeutic for alcohol use disorder
Fulltext Access 11 Pages 2017
The effects of reduced dopamine transporter function and chronic lithium on motivation, probabilistic learning, and neurochemistry in mice: Modeling bipolar mania
Fulltext Access 11 Pages 2017
How Deformation Behavior Controls Product Performance After Twin Screw Granulation With High Drug Loads and Crospovidone as Disintegrant
Fulltext Access 11 Pages 2017
The journey from an allopathic to natural treatment approach: A scoping review of medical tourism and health systems
Fulltext Access 11 Pages 2017
Industry Perspective on Contemporary Protein-Binding Methodologies: Considerations for Regulatory Drug-Drug Interaction and Related Guidelines on Highly Bound Drugs
Fulltext Access 11 Pages 2017
Design, synthesis and immunological evaluation of novel amphiphilic desmuramyl peptides
Fulltext Access 11 Pages 2017
Design and synthesis of dalbergin analogues and evaluation of anti-osteoporotic activity
Fulltext Access 11 Pages 2017
Development of a Rational Design Space for Optimizing Mixing Conditions for Formation of Adhesive Mixtures for Dry-Powder Inhaler Formulations
Fulltext Access 11 Pages 2017
Lipophilic methylene violet analogues as modulators of mitochondrial function and dysfunction
Fulltext Access 11 Pages 2017
Novel antioxidant bromophenols with acetylcholinesterase, butyrylcholinesterase and carbonic anhydrase inhibitory actions
Fulltext Access 11 Pages 2017
Oxidative transformation of a tunichrome model compound provides new insight into the crosslinking and defense reaction of tunichromes
Fulltext Access 11 Pages 2017
Synchrony measure for a neuron driven by excitatory and inhibitory inputs and its adaptation to experimentally-recorded data
Fulltext Access 11 Pages 2017
Ion-paired pirenzepine-loaded micelles as an ophthalmic delivery system for the treatment of myopia
Fulltext Access 11 Pages 2017
Original ArticleEffect of particle size on the biodistribution, toxicity, and efficacy of drug-loaded polymeric nanoparticles in chemoradiotherapy
Fulltext Access 11 Pages 2017
Original ArticleThree-dimensional functional human neuronal networks in uncompressed low-density electrospun fiber scaffolds
Fulltext Access 11 Pages 2017
Rapid and high-throughput colorimetric screening for anti-aggregation reagents of protein conformational diseases by using gold nanoplasmonic particles
Fulltext Access 11 Pages 2017
Inflammation-induced brain endothelial activation leads to uptake of electrostatically stabilized iron oxide nanoparticles via sulfated glycosaminoglycans
Fulltext Access 11 Pages 2017
Adaptation of targeted nanocarriers to changing requirements in antimalarial drug delivery
Fulltext Access 11 Pages 2017
Nanotubular topography enhances the bioactivity of titanium implants
Fulltext Access 11 Pages 2017
Aggregation-induced emission probes for cancer theranostics
Fulltext Access 11 Pages 2017
Novel nucleotide analogues bearing (1H-1,2,3-triazol-4-yl)phosphonic acid moiety as inhibitors of Plasmodium and human 6-oxopurine phosphoribosyltransferases
Fulltext Access 11 Pages 2017
Synthesis and preliminary biological evaluation of new phenolic and catecholic dehydroamino acid derivatives
Fulltext Access 11 Pages 2017
Preparation of novel ring-A fused azole derivatives of betulin and evaluation of their cytotoxicity
Fulltext Access 11 Pages 2017
Rigid aromatic linking moiety in cationic lipids for enhanced gene transfection efficiency
Fulltext Access 11 Pages 2017
New cycloartane type-triterpenoids from the areal parts of Caragana sukiensis and their biological activities
Fulltext Access 11 Pages 2017
Optimization of substituted imidazobenzodiazepines as novel asthma treatments
Fulltext Access 11 Pages 2017
A statistical study on the development of micro particulate sustained drug delivery system for Losartan potassium by 32 factorial design approach
Fulltext Access 11 Pages 2017
Novel tacrine derivatives exhibiting improved acetylcholinesterase inhibition: Design, synthesis and biological evaluation
Fulltext Access 11 Pages 2017
Synthesis, characterization and pharmacological evaluation of different 1,3,4-oxadiazole and acetamide derivatives of ethyl nipecotate
Fulltext Access 11 Pages 2017
Reduction of imidazolium salts - An approach to diazocines and diazocanes
Fulltext Access 12 Pages 2017
Derivatives of caffeic acid, a natural antioxidant, as the basis for the discovery of novel nonpeptidic neurotrophic agents
Fulltext Access 12 Pages 2017
Synthesis, spectroscopic characterization and biological evaluation of unsymmetrical aminosquarylium cyanine dyes
Fulltext Access 12 Pages 2017
Green tea effects on cognition, mood and human brain function: A systematic review
Fulltext Access 12 Pages 2017
Citral, a monoterpenoid aldehyde interacts synergistically with norfloxacin against methicillin resistant Staphylococcus aureus
Fulltext Access 12 Pages 2017
Design, synthesis, and pharmacological evaluation of a novel series of hormone sensitive lipase inhibitor
Fulltext Access 12 Pages 2017
Modelling the interactions between animal venom peptides and membrane proteins
Fulltext Access 12 Pages 2017
Conversion of Pregabalin to 4-Isobutylpyrrolidone-2
Fulltext Access 12 Pages 2017
Synthesis of different heterocycles-linked chalcone conjugates as cytotoxic agents and tubulin polymerization inhibitors
Fulltext Access 12 Pages 2017
Design and synthesis of a novel series of orally active, selective somatostatin receptor 2 agonists for the treatment of type 2 diabetes
Fulltext Access 12 Pages 2017
Chemical protein synthesis: Inventing synthetic methods to decipher how proteins work
Fulltext Access 12 Pages 2017
Conformational studies of Gram-negative bacterial quorum sensing 3-oxo N-acyl homoserine lactone molecules
Fulltext Access 12 Pages 2017
Cancer-on-a-chip systems at the frontier of nanomedicine
Fulltext Access 12 Pages 2017
Quinolines: Microwave-assisted synthesis and their antifungal, anticancer and radical scavenger properties
Fulltext Access 12 Pages 2017
Green synthesis of novel spiro-indenoquinoxaline derivatives and their cholinesterases inhibition activity
Fulltext Access 12 Pages 2017
Follicle-stimulating hormone encapsulation in the cholesterol-modified chitosan nanoparticles via molecular dynamics simulations and binding free energy calculations
Fulltext Access 12 Pages 2017
The role of hydrazide compounds in asymmetric synthesis
Fulltext Access 12 Pages 2017
Novel diphenylthiazole derivatives with multi-target mechanism: Synthesis, docking study, anticancer and anti-inflammatory activities
Fulltext Access 12 Pages 2017
Synthesis and antiproliferative activity of 2-chlorophenyl carboxamide thienopyridines
Fulltext Access 12 Pages 2017
Synthesis and biological evaluations of new nitric oxide-anti-inflammatory drug hybrids
Fulltext Access 12 Pages 2017
Graphical contents list
Fulltext Access 12 Pages 2017
Graphical contents list
Fulltext Access 12 Pages 2017
New bicyclic brominated furanones as potent autoinducer-2 quorum-sensing inhibitors against bacterial biofilm formation
Fulltext Access 12 Pages 2017
Ciprofloxacin-nitroxide hybrids with potential for biofilm control
Fulltext Access 12 Pages 2017
Synthesis, molecular modeling studies and bronchodilation properties of nicotinonitrile containing-compounds
Fulltext Access 12 Pages 2017
One-pot three steps cascade synthesis of novel isoandrographolide analogues and their cytotoxic activity
Fulltext Access 12 Pages 2017
The hydrogen bond directing effect in nitrile oxide cycloadditions to allylic substituted cyclopentenes
Fulltext Access 12 Pages 2017
Insight into hydrogen bonding of terephthalamides with amino acids: Synthesis, structural and spectroscopic investigations
Fulltext Access 12 Pages 2017
New reaction of formation of the fused tricyclic bispyrroloquinone ring system
Fulltext Access 12 Pages 2017
Acupuncture for smoking cessation: A protocol for a systematic review of randomized controlled trials
Fulltext Access 12 Pages 2017
Glycogen synthase kinase 3 beta alters anxiety-, depression-, and addiction-related behaviors and neuronal activity in the nucleus accumbens shell
Fulltext Access 12 Pages 2017
Transparent ciprofloxacin-povidone antibiotic films and nanofiber mats as potential skin and wound care dressings
Fulltext Access 12 Pages 2017
Review - An update on the use of oral phospholipid excipients
Fulltext Access 12 Pages 2017
Re-programming pullulan for targeting and controlled release of doxorubicin to the hepatocellular carcinoma cells
Fulltext Access 12 Pages 2017
Development of Salbutamol Sulphate fast disintegrating sublingual tablets with enhanced bioavailability and improved clinical efficacy for potential treatment of asthma
Fulltext Access 12 Pages 2017
Monoacyl-phospatidylcholine nanostructured lipid carriers: Influence of lipid and surfactant content on in vitro skin permeation of flufenamic acid and fluconazole
Fulltext Access 12 Pages 2017
Evaluation of retrograded starch as excipient for controlled release matrix tablets
Fulltext Access 12 Pages 2017
Traumatic brain injury, diabetic neuropathy and altered-psychiatric health: The fateful triangle
Fulltext Access 12 Pages 2017
Sensitivity to cocaine in adult mice is due to interplay between genetic makeup, early environment and later experience
Fulltext Access 12 Pages 2017
Chronic fluoxetine ameliorates adolescent chronic nicotine exposure-induced long-term adult deficits in trace conditioning
Fulltext Access 12 Pages 2017
Paliperidone reverts Toll-like receptor 3 signaling pathway activation and cognitive deficits in a maternal immune activation mouse model of schizophrenia
Fulltext Access 12 Pages 2017
Sex differences in responses of the basolateral-central amygdala circuit to alcohol, corticosterone and their interaction
Fulltext Access 12 Pages 2017
Delta-opioid receptor antagonism leads to excessive ethanol consumption in mice with enhanced activity of the endogenous opioid system
Fulltext Access 12 Pages 2017
Inhibitory effect of punicalagin on lipopolysaccharide-induced neuroinflammation, oxidative stress and memory impairment via inhibition of nuclear factor-kappaB
Fulltext Access 12 Pages 2017
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