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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Fasting as possible complementary approach for polycystic ovary syndrome: Hope or hype?
Fulltext Access 13 Pages 2017
Novel ferulic amide derivatives with tertiary amine side chain as acetylcholinesterase and butyrylcholinesterase inhibitors: The influence of carbon spacer length, alkylamine and aromatic group
Fulltext Access 13 Pages 2017
Synthesis and salient chemosensing properties of a new thiazole-azo derivative
Fulltext Access 13 Pages 2017
Observations concerning the synthesis of heteroatom-containing 9-membered benzo-fused rings by ring-closing metathesis
Fulltext Access 13 Pages 2017
Expanding available pyrazole substitution patterns by sydnone cycloaddition reactions
Fulltext Access 13 Pages 2017
Application of oxygen/nitrogen substituted donor-acceptor cyclopropanes in the total synthesis of natural products
Fulltext Access 13 Pages 2017
Exploring the scope of the Gewald reaction: Expansion to a four-component process
Fulltext Access 13 Pages 2017
Applying attractor dynamics to infer gene regulatory interactions involved in cellular differentiation
Fulltext Access 13 Pages 2017
Effect of dispersal in two-patch prey-predator system with positive density dependence growth of preys
Fulltext Access 13 Pages 2017
ReviewKeynoteIs the European regulatory framework sufficient to assure the safety of citizens using health products containing nanomaterials?
Fulltext Access 13 Pages 2017
Remodeling the blood-brain barrier microenvironment by natural products for brain tumor therapy
Fulltext Access 13 Pages 2017
Vaginal semisolid products: Technological performance considering physiologic parameters
Fulltext Access 13 Pages 2017
Block ionomer micellar nanoparticles from double hydrophilic copolymers, classifications and promises for delivery of cancer chemotherapeutics
Fulltext Access 13 Pages 2017
Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity
Fulltext Access 13 Pages 2017
Fabrication of liquid and solid self-double emulsifying drug delivery system of atenolol by response surface methodology
Fulltext Access 13 Pages 2017
Percutaneous transport of psychotropic agents
Fulltext Access 13 Pages 2017
Polymer-lipid hybrid systems used as carriers for insulin delivery
Fulltext Access 13 Pages 2017
Role of orexin type-1 receptors in paragiganto-coerulear modulation of opioid withdrawal and tolerance: A site specific focus
Fulltext Access 13 Pages 2017
Cannabinoids as hippocampal network administrators
Fulltext Access 13 Pages 2017
Susceptibility to traumatic stress sensitizes the dopaminergic response to cocaine and increases motivation for cocaine
Fulltext Access 13 Pages 2017
A role for the peripheral immune system in the development of alcohol use disorders?
Fulltext Access 13 Pages 2017
Agmatine ameliorates type 2 diabetes induced-Alzheimer's disease-like alterations in high-fat diet-fed mice via reactivation of blunted insulin signalling
Fulltext Access 13 Pages 2017
Osteoinductive effects of glyceollins on adult mesenchymal stromal/stem cells from adipose tissue and bone marrow
Fulltext Access 13 Pages 2017
Features of electronic circular dichroism and tips for its use in determining absolute configuration
Fulltext Access 13 Pages 2017
Biological evaluation of pyridone alkaloids on the endocannabinoid system
Fulltext Access 13 Pages 2017
Recently reported biological activities of pyrazole compounds
Fulltext Access 13 Pages 2017
Design, synthesis and biological evaluation of 2-phenylquinoline-4-carboxamide derivatives as a new class of tubulin polymerization inhibitors
Fulltext Access 13 Pages 2017
Catabolism of antibody drug conjugates and characterization methods
Fulltext Access 13 Pages 2017
New insights into highly potent tyrosinase inhibitors based on 3-heteroarylcoumarins: Anti-melanogenesis and antioxidant activities, and computational molecular modeling studies
Fulltext Access 13 Pages 2017
Synthesis and antitumor activities of 1,2,3-triazines and their benzo- and heterofused derivatives
Fulltext Access 13 Pages 2017
Mixed Reality Meets Pharmaceutical Development
Fulltext Access 13 Pages 2017
High-Throughput Lipolysis in 96-Well Plates for Rapid Screening of Lipid-Based Drug Delivery Systems
Fulltext Access 13 Pages 2017
Facile synthesis of fluoro, methoxy, and methyl substituted ferrocene-based urea complexes as potential therapeutic agents
Fulltext Access 13 Pages 2017
Intelligent substance delivery into cells using cell-penetrating peptides
Fulltext Access 13 Pages 2017
Discovery of 5,6-diaryl-1,2,4-triazines hybrids as potential apoptosis inducers
Fulltext Access 13 Pages 2017
Design, synthesis and biological evaluation of indole derivatives as Vif inhibitors
Fulltext Access 13 Pages 2017
In silico selection and cell-based characterization of selective and bioactive compounds for androgen-dependent prostate cancer cell
Fulltext Access 13 Pages 2017
Novel triclabendazole prodrug: A highly water soluble alternative for the treatment of fasciolosis
Fulltext Access 13 Pages 2017
Synthesis, antiviral activity, and molecular docking study of trans-ferulic acid derivatives containing acylhydrazone moiety
Fulltext Access 13 Pages 2017
Identification of highly selective and potent orexin receptor 1 antagonists derived from a dual orexin receptor 1/2 antagonist based on the structural framework of pyrazoylethylbenzamide
Fulltext Access 13 Pages 2017
Synthesis of naphthazarin derivatives and identification of novel thioredoxin reductase inhibitor as potential anticancer agent
Fulltext Access 13 Pages 2017
Combination of amino acid/dipeptide with ligustrazine-betulinic acid as antitumor agents
Fulltext Access 13 Pages 2017
Carbohydrazones as new class of carbonic anhydrase inhibitors: Synthesis, kinetics, and ligand docking studies
Fulltext Access 13 Pages 2017
Original ArticleMechanically tuned nanocomposite coating on titanium metal with integrated properties of biofilm inhibition, cell proliferation, and sustained drug delivery
Fulltext Access 13 Pages 2017
Rational design of reversible inhibitors for trehalose 6-phosphate phosphatases
Fulltext Access 13 Pages 2017
Antimicrobial silver-filled silica nanorattles with low immunotoxicity in dendritic cells
Fulltext Access 13 Pages 2017
Nanotheranostic approaches for management of bloodstream bacterial infections
Fulltext Access 13 Pages 2017
Original ArticleNano-analyses of wear particles from metal-on-metal and non-metal-on-metal dual modular neck hip arthroplasty
Fulltext Access 13 Pages 2017
Ketogenic diet and anorexia nervosa
Fulltext Access 14 Pages 2017
Synthesis and anti-inflammatory activity of isoquebecol
Fulltext Access 14 Pages 2017
Design, synthesis, and bioactivities of novel oxadiazole-substituted pyrazole oximes
Fulltext Access 14 Pages 2017
A Practical Framework Toward Prediction of Breaking Force and Disintegration of Tablet Formulations Using Machine Learning Tools
Fulltext Access 14 Pages 2017
Synthesis of cholesteryl doxorubicin and its anti-cancer activity
Fulltext Access 14 Pages 2017
Molecular Dynamics Simulation of Amorphous Hydroxypropylmethylcellulose and Its Mixtures With Felodipine and Water
Fulltext Access 14 Pages 2017
Challenges in Translational Development of Pharmaceutical Cocrystals
Fulltext Access 14 Pages 2017
Gene expression profiling in the human alcoholic brain
Fulltext Access 14 Pages 2017
Neurochemical and metabolic effects of acute and chronic alcohol in the human brain: Studies with positron emission tomography
Fulltext Access 14 Pages 2017
Atypical binding at dopamine and serotonin transporters contribute to the discriminative stimulus effects of mephedrone
Fulltext Access 14 Pages 2017
Serotonergic mechanisms of trigeminal meningeal nociception: Implications for migraine pain
Fulltext Access 14 Pages 2017
Prediction of protein structural class for low-similarity sequences using Chou's pseudo amino acid composition and wavelet denoising
Fulltext Access 14 Pages 2017
Effects of bingeing on fat during adolescence on the reinforcing effects of cocaine in adult male mice
Fulltext Access 14 Pages 2017
Trends on Analytical Characterization of Polysorbates and Their Degradation Products in Biopharmaceutical Formulations
Fulltext Access 14 Pages 2017
Serum metabolomics analysis reveals that obvious cardioprotective effects of low dose Sini decoction against isoproterenol-induced myocardial injury in rats
Fulltext Access 14 Pages 2017
Lead selection of antiparasitic compounds from a focused library of benzenesulfonyl derivatives of heterocycles
Fulltext Access 14 Pages 2017
Synthesis, pharmacological activities and molecular docking studies of pyrazolyltriazoles as anti-bacterial and anti-inflammatory agents
Fulltext Access 14 Pages 2017
On the Use of Group Sequential Study Designs for the Test of Bioequivalence for Complicated Products
Fulltext Access 14 Pages 2017
Design, synthesis and cytotoxic activities of scopoletin-isoxazole and scopoletin-pyrazole hybrids
Fulltext Access 14 Pages 2017
9-Substituted acridine derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors possessing antioxidant activity for Alzheimer's disease treatment
Fulltext Access 14 Pages 2017
Exploration of pyrrole derivatives to find an effective potassium-competitive acid blocker with moderately long-lasting suppression of gastric acid secretion
Fulltext Access 14 Pages 2017
Pharmacokinetics and therapeutic efficiency of a novel cationic liposome nano-formulated all trans retinoic acid in lung cancer mice model
Fulltext Access 14 Pages 2017
Graphical contents list
Fulltext Access 14 Pages 2017
Discovery of dehydroabietic acid sulfonamide based derivatives as selective matrix metalloproteinases inactivators that inhibit cell migration and proliferation
Fulltext Access 14 Pages 2017
Design and discovery of silybin analogues as antiproliferative compounds using a ring disjunctive - Based, natural product lead optimization approach
Fulltext Access 14 Pages 2017
Woodward's unfinished total synthesis of colchicine, a collaborative prelude
Fulltext Access 14 Pages 2017
Theoretical investigation of the photochromic properties of [2.2]paracyclophane-bridged imidazole dimers and bis(imidazole) dimers
Fulltext Access 14 Pages 2017
Synthesis and antiplasmodial activity of novel indoleamide derivatives bearing sulfonamide and triazole pharmacophores
Fulltext Access 14 Pages 2017
Photochemical behaviour of furylidene carbonyl compounds
Fulltext Access 14 Pages 2017
Synthesis and properties of highly lipophilic phosphazene bases
Fulltext Access 14 Pages 2017
An efficient material via meta-position connection as thermally activated delayed fluorescence emitter for organic light-emitting diodes
Fulltext Access 14 Pages 2017
Synthesis of peptide oxazolones and related compounds
Fulltext Access 14 Pages 2017
Chemical syntheses of the cochliomycins and certain related resorcylic acid lactones
Fulltext Access 14 Pages 2017
Review articleComputational complexity of algorithms for sequence comparison, short-read assembly and genome alignment
Fulltext Access 14 Pages 2017
Investigation of orexin-2 selective receptor antagonists: Structural modifications resulting in dual orexin receptor antagonists
Fulltext Access 14 Pages 2017
Benzenesulphonamide inhibitors of the cytolytic protein perforin
Fulltext Access 14 Pages 2017
Are sage, rosemary and lemon balm effective interventions in dementia? A narrative review of the clinical evidence
Fulltext Access 14 Pages 2017
A model of dance/movement therapy for resilience-building in people living with chronic pain
Fulltext Access 14 Pages 2017
Synthesis and biological evaluation of a new series of cinnamic acid amide derivatives as potent haemostatic agents containing a 2-aminothiazole substructure
Fulltext Access 14 Pages 2017
Macrophage selective photodynamic therapy by meta-tetra(hydroxyphenyl)chlorin loaded polymeric micelles: A possible treatment for cardiovascular diseases
Fulltext Access 14 Pages 2017
An ethnopharmacological analysis of medicinal plants used by the Adiyan community in Wayanad district of Kerala, India
Fulltext Access 14 Pages 2017
Design and synthesis of new piperidone grafted acetylcholinesterase inhibitors
Fulltext Access 14 Pages 2017
Impact of dose and surface features on plasmatic and liver concentrations of biodegradable polymeric nanocapsules
Fulltext Access 14 Pages 2017
Dual-mechanism gastroretentive drug delivery system loaded with an amorphous solid dispersion prepared by hot-melt extrusion
Fulltext Access 14 Pages 2017
Prediction of Ketoconazole absorption using an updated in vitro transfer model coupled to physiologically based pharmacokinetic modelling
Fulltext Access 14 Pages 2017
Glycyrrhetic acid, but not glycyrrhizic acid, strengthened entecavir activity by promoting its subcellular distribution in the liver via efflux inhibition
Fulltext Access 15 Pages 2017
Mechanisms contributing to cognitive deficits in cannabis users
Fulltext Access 15 Pages 2017
Graphical abstract contents listing
Fulltext Access 15 Pages 2017
Synthesis and biological evaluation of curcumin inspired indole analogues as tubulin polymerization inhibitors
Fulltext Access 15 Pages 2017
Review articleReviewing evidence for systematic transcriptional deletions, nucleotide exchanges, and expanded codons, and peptide clusters in human mitochondria
Fulltext Access 15 Pages 2017
Effect of diseases on symbiotic systems
Fulltext Access 15 Pages 2017
Synthesis and biological evaluation of novel chalcone derivatives as a new class of microtubule destabilizing agents
Fulltext Access 15 Pages 2017
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