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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Methods for the preparation of amorphous solid dispersions - A comparative study
Fulltext Access 10 Pages 2017
Salicylate-based phytopharmaceuticals induce adaptive cytokine and chemokine network responses in human fibroblast cultures
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The kynurenine pathway in schizophrenia and bipolar disorder
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Transgenerational attenuation of opioid self-administration as a consequence of adolescent morphine exposure
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Early life disruption to the ghrelin system with over-eating is resolved in adulthood in male rats
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Developmental regulation of hippocampal long-term depression by cofilin-mediated actin reorganization
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Loperamide inhibits sodium channels to alleviate inflammatory hyperalgesia
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Metabotropic glutamate receptor 2 inhibits thalamically-driven glutamate and dopamine release in the dorsal striatum
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Endocannabinoid modulation of dopamine neurotransmission
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Brain temperature effects of intravenous heroin: State dependency, environmental modulation, and the effects of dose
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3D printed liner for treatment of periprosthetic joint infections
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The affection of the disturbance of the hydrodynamics of blood in case of stress on pathological increase of level of low density lipoproteins in blood. The formation of cylindrical plaques, and their participation in the development of acute ischemic dis
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The clinical reasoning of Western herbal practitioners: A qualitative feasibility study
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Visualizing spatially decomposed intermolecular correlations in the infrared spectra of aprotic liquids
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Numerical simulation of Franz diffusion experiment: Application to drug loaded soft contact lenses
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Synthesis, characterization and evaluation of antioxidant properties of catechin hydrate nanoparticles
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Montmorillonite nanoclay as a multifaceted drug-delivery carrier: A review
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Role of butter oil in brain targeted delivery of Quetiapine fumarate microemulsion via intranasal route
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Application of surfactants in solid dispersion technology for improving solubility of poorly water soluble drugs
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Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice
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Towards prostate cancer gene therapy: Development of a chlorotoxin-targeted nanovector for toxic (melittin) gene delivery
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Statistical investigation of simulated fed intestinal media composition on the equilibrium solubility of oral drugs
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Extracellular vesicles as a source for non-invasive biomarkers in bladder cancer progression
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Archaeal lipids in oral delivery of therapeutic peptides
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A rational approach to elucidate human monoamine oxidase molecular selectivity
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Stem cells in cardiovascular diseases: turning bad days into good ones
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Atmospheric Spray Freeze-Drying: Numerical Modeling and Comparison With Experimental Measurements
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Nonadditive Effects of Repetitive Administration of Lipoplexes in Immunocompetent Mice
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Dispersive Raman Spectroscopy for Quantifying Amorphous Drug Content in Intact Tablets
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Assessment of Bioequivalence of Weak Base Formulations Under Various Dosing Conditions Using Physiologically Based Pharmacokinetic Simulations in Virtual Populations. Case Examples: Ketoconazole and Posaconazole
Fulltext Access 10 Pages 2017
Traditional uses of wild food plants, medicinal plants, and domestic remedies in Albanian, Aromanian and Macedonian villages in South-Eastern Albania
Fulltext Access 10 Pages 2017
Pharmaceutical development of a generic corticoid semisolid formulation
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A novel microdialysis-dissolution/permeation system for testing oral dosage forms: A proof-of-concept study
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Novel expandable gastro retentive system by unfolding mechanism of levetiracetam using simple lattice design - Formulation optimization and in vitro evaluation
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Dissolution enhancement of leflunomide incorporating self emulsifying drug delivery systems and liquisolid concepts
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Imaging the glutamate receptor subtypes-Much achieved, and still much to do
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Constrained cell penetrating peptides
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Biomimetic nanofibrous scaffolds for neural tissue engineering and drug development
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Treatment schedule and estrogen receptor-status influence acquisition of doxorubicin resistance in breast cancer cells
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A comprehensive review on polyelectrolyte complexes
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Emerging technologies for prediction of drug candidate efficacy in the preclinical pipeline
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Ammonium iodide-promoted unprecedented arylsulfonylation of quinone with sodium arylsulfinates
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From the hive: Honey, a novel weapon against cancer
Fulltext Access 10 Pages 2017
Identification of a novel hormone sensitive lipase inhibitor with a reduced potential of reactive metabolites formation
Fulltext Access 10 Pages 2017
Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin
Fulltext Access 10 Pages 2017
Synthesis and biological activity of new phthalimides as potential anti-inflammatory agents
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A novel serine racemase inhibitor suppresses neuronal over-activation in vivo
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Discovery of new leads against Mycobacterium tuberculosis using scaffold hopping and shape based similarity
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Synthesis and optical properties of pyrrolidinyl peptide nucleic acid bearing a base discriminating fluorescence nucleobase 8-(pyrene-1-yl)-ethynyladenine
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Enzymatic synthesis of 1,3-dihydroxyphenylacetoyl-sn-glycerol: Optimization by response surface methodology and evaluation of its antioxidant and antibacterial activities
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Graphical contents list
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Novel family of fused tricyclic [1,4]diazepines: Design, synthesis, crystal structures and molecular docking studies
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Efficient one-pot method for the synthesis of bis-propargylamines by the reaction of terminal acetylenes with 1,5,3-dioxazepanes catalyzed by cоpper chloride
Fulltext Access 10 Pages 2017
The strain-promoted alkyne-nitrone and alkyne-nitrile oxide cycloaddition reactions: A theoretical study
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Structural and electronic modifications of pyridones and pyrones via regioselective bromination and trifluoromethylation
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Synthesis and equilibrium multistate of new pyrano-3-deoxyanthocyanin-type pigments in aqueous solutions
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Fusaric acid and analogues as Gram-negative bacterial quorum sensing inhibitors
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Green synthesis and anticancer potential of chalcone linked-1,2,3-triazoles
Fulltext Access 10 Pages 2017
Design, synthesis and antiproliferative activity of decarbonyl luotonin analogues
Fulltext Access 10 Pages 2017
Design, synthesis and antibacterial evaluation of novel pleuromutilin derivatives possessing piperazine linker
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Clathrodin, hymenidin and oroidin, and their synthetic analogues as inhibitors of the voltage-gated potassium channels
Fulltext Access 10 Pages 2017
Discovery of cycloalkyl-fused N-thiazol-2-yl-benzamides as tissue non-specific glucokinase activators: Design, synthesis, and biological evaluation
Fulltext Access 10 Pages 2017
Graphical contents list
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Iron catalysis for the synthesis of ligands: Exploring the products of hydrophosphination as ligands in cross-coupling
Fulltext Access 10 Pages 2017
Synthesis and biological evaluation of novel non-racemic indole-containing allocolchicinoids
Fulltext Access 10 Pages 2017
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus
Fulltext Access 10 Pages 2017
Anti-leishmanial and cytotoxic activities of amino acid-triazole hybrids: Synthesis, biological evaluation, molecular docking and in silico physico-chemical properties
Fulltext Access 10 Pages 2017
Synthesis and bioactivity evaluation of 2,3-diaryl acrylonitrile derivatives as potential anticancer agents
Fulltext Access 10 Pages 2017
Synthesis and cell imaging applications of fluorescent mono/di/tri-heterocyclyl-2,6-dicyanoanilines
Fulltext Access 10 Pages 2017
Design, synthesis and antitumor activity of Novel Sorafenib derivatives bearing pyrazole scaffold
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Synthesis of threo- and erythro-configured trihydroxy open chain lipophilic ketones as possible anti-mycobacterial agents
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Near-infrared light-responsive nanoparticles with thermosensitive yolk-shell structure for multimodal imaging and chemo-photothermal therapy of tumor
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Imaging the delivery of drug-loaded, iron-stabilized micelles
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Metallic nanoparticles to eradicate bacterial bone infection
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Chitosan-based nanocomposites for the repair of bone defects
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Therapeutic interventions for aging: the case of cellular senescence
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Comparison of video analysis and simulations of a drum coating process
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A novel nanosuspension of andrographolide: Preparation, characterization and passive liver target evaluation in rats
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The efficacy of probiotics as pharmacological treatment of cutaneous wounds: Meta-analysis of animal studies
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Anticancer drug-loaded quantum dots engineered polymeric nanoparticles: Diagnosis/therapy combined approach
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Selection of effective cocrystals former for dissolution rate improvement of active pharmaceutical ingredients based on lipoaffinity index
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The interaction of dendrimer-doxorubicin conjugates with a model pulmonary epithelium and their cosolvent-free, pseudo-solution formulations in pressurized metered-dose inhalers
Fulltext Access 10 Pages 2017
Effects of Tai chi on adults with essential hypertension in China: A systematic review and meta-analysis
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Toxicological potential of acyl glucuronides and its assessment
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Quantitative prediction of therapeutic antibody pharmacokinetics after intravenous and subcutaneous injection in human
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Synthesis of hydroxycinnamic acid derivatives as mitochondria-targeted antioxidants and cytotoxic agents
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Amino-functionalized poloxamer 407 with both mucoadhesive and thermosensitive properties: preparation, characterization and application in a vaginal drug delivery system
Fulltext Access 10 Pages 2017
Potassium 2-(1-hydroxypentyl)-benzoate attenuates neuronal apoptosis in neuron-astrocyte co-culture system through neurotrophy and neuroinflammation pathway
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Polymorphism of a Novel Sodium Ion Channel Blocker
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Measuring the effectiveness and impact of an open innovation platform
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An efficient finite-difference strategy for sensitivity analysis of stochastic models of biochemical systems
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A binary representation of the genetic code
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Cellular non-linear network model of microbial fuel cell
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Energy conservation and maximal entropy production in enzyme reactions
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Green and mild laccase-catalyzed aerobic oxidative coupling of benzenediol derivatives with various sodium benzenesulfinates
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Recent advances in the transition-metal catalyzed synthesis of multisubstituted pentenolides and related pyranones
Fulltext Access 10 Pages 2017
Recent developments of cavitand-recessed type metal catalysts
Fulltext Access 10 Pages 2017
A simple and efficient approach for the synthesis of 2-aminated quinazoline derivatives via metal free oxidative annulation
Fulltext Access 10 Pages 2017
Synthesis of novel 3,4,6-trisubstituted quinolines enabled by a Gould-Jacobs cyclization
Fulltext Access 10 Pages 2017
Synthesis of mono-, di- and triporphyrin building blocks by click chemistry for photodynamic therapy application
Fulltext Access 10 Pages 2017
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