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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Decreased use of spatial pattern separation in contemporary lifestyles may contribute to hippocampal atrophy and diminish mental health
Fulltext Access 9 Pages 2017
Are Russian propolis ethanol extracts the future for the prevention of medical and biomedical implant contaminations?
Fulltext Access 9 Pages 2017
Mechanisms underlying the wound healing potential of propolis based on its in vitro antioxidant activity
Fulltext Access 9 Pages 2017
Cardioprotection of stevioside on stunned rat hearts: A mechano-energetical study
Fulltext Access 9 Pages 2017
Pharmacogenetic reactivation of the original engram evokes an extinguished fear memory
Fulltext Access 9 Pages 2017
Enhancing inhibitory synaptic function reverses spatial memory deficits in Shank2 mutant mice
Fulltext Access 9 Pages 2017
Effects of tetrahydrocannabinol on glucose uptake in the rat brain
Fulltext Access 9 Pages 2017
Carbonic anhydrase activation enhances object recognition memory in mice through phosphorylation of the extracellular signal-regulated kinase in the cortex and the hippocampus
Fulltext Access 9 Pages 2017
Double dissociation of the anterior and posterior dorsomedial caudate-putamen in the acquisition and expression of associative learning with the nicotine stimulus
Fulltext Access 9 Pages 2017
Mitochondrial energy metabolism of rat hippocampus after treatment with the antidepressants desipramine and fluoxetine
Fulltext Access 9 Pages 2017
Studies using macaque monkeys to address excessive alcohol drinking and stress interactions
Fulltext Access 9 Pages 2017
Neuropharmacological characterization of the new psychoactive substance methoxetamine
Fulltext Access 9 Pages 2017
The hormonal sensitivity hypothesis: A review and new findings
Fulltext Access 9 Pages 2017
Design, synthesis and biological activity of 3-pyrazine-2-yl-oxazolidin-2-ones as novel, potent and selective inhibitors of mutant isocitrate dehydrogenase 1
Fulltext Access 9 Pages 2017
In vitro cytotoxic, antibacterial, anti-inflammatory and antioxidant activities and phenolic content in wild-grown flowers of common daisy-A medicinal plant
Fulltext Access 9 Pages 2017
Relationship of hard segment concentration in polyurethane-urea elastomers with mechanical, thermal and drug release properties
Fulltext Access 9 Pages 2017
Preparation, characterization and biocompatibility of poly(vinyl alcohol) films containing tetracycline hydrochloride-loaded quaternized chitosan nanoparticles
Fulltext Access 9 Pages 2017
Bovine serum albumin-based nanoparticles containing resveratrol: Characterization and antioxidant activity
Fulltext Access 9 Pages 2017
Effects of temperature ramp rate during the primary drying process on the properties of amorphous-based lyophilized cake, Part 1: Cake characterization, collapse temperature and drying behavior
Fulltext Access 9 Pages 2017
Characterization of orally disintegrating films: A feasibility study using an electronic taste sensor and a flow-through cell
Fulltext Access 9 Pages 2017
Rapid loading and prolonged release of latanoprost from a silicone hydrogel contact lens
Fulltext Access 9 Pages 2017
Formulation of clarithromycin floating microspheres for eradication of Helicobacter pylori
Fulltext Access 9 Pages 2017
Comparison of 2 strategies to enhance pyridoclax solubility: Nanoemulsion delivery system versus salt synthesis
Fulltext Access 9 Pages 2017
A generic viral dynamic model to systematically characterize the interaction between oncolytic virus kinetics and tumor growth
Fulltext Access 9 Pages 2017
Silver nanoparticle treatment ameliorates biliary atresia syndrome in rhesus rotavirus inoculated mice
Fulltext Access 9 Pages 2017
Myotonic dystrophy: candidate small molecule therapeutics
Fulltext Access 9 Pages 2017
Animal models of cardiovascular disease as test beds of bioengineered vascular grafts
Fulltext Access 9 Pages 2017
Glibenclamide Nanocrystals in a Biodegradable Chitosan Patch for Transdermal Delivery: Engineering, Formulation, and Evaluation
Fulltext Access 9 Pages 2017
A Comparison of Aerosolization and Homogenization Techniques for Production of Alginate Microparticles for Delivery of Corticosteroids to the Colon
Fulltext Access 9 Pages 2017
Single-step Coprocessing of Cohesive Powder via Mechanical Dry Coating for Direct Tablet Compression
Fulltext Access 9 Pages 2017
Study on the Unfrozen Water Quantity of Maximally Freeze-Concentrated Solutions for Multicomponent Lyoprotectants
Fulltext Access 9 Pages 2017
The Effect of Specific Surface Area of Chitin-Metal Silicate Coprocessed Excipient on the Chemical Decomposition of Cefotaxime Sodium
Fulltext Access 9 Pages 2017
Synergistic Effect of Cavitation and Agitation on Protein Aggregation
Fulltext Access 9 Pages 2017
Assessment of the Blood-Brain Barrier Permeability of Potential Neuroprotective Aurones in Parallel Artificial Membrane Permeability Assay and Porcine Brain Endothelial Cell Models
Fulltext Access 9 Pages 2017
Hydrogen Bonding Interactions and Enthalpy Relaxation in Sugar/Protein Glasses
Fulltext Access 9 Pages 2017
Paclitaxel Encapsulated in Halloysite Clay Nanotubes for Intestinal and Intracellular Delivery
Fulltext Access 9 Pages 2017
An automated method by which effects of compounds on locomotor activity and spontaneous neuropathic pain-specific movements can be simultaneously evaluated in rats with chronic-constriction nerve injury
Fulltext Access 9 Pages 2017
Engineered nanoparticles for the detection, treatment and prevention of atherosclerosis: how close are we?
Fulltext Access 9 Pages 2017
Preparation of liposomes containing small gold nanoparticles using electrostatic interactions
Fulltext Access 9 Pages 2017
Near infra red spectroscopy: a tool for solid state characterization
Fulltext Access 9 Pages 2017
Metal-free one-pot synthesis of benzofurans with ynones and quinones through aza-Michael/Michael/annulation sequence
Fulltext Access 9 Pages 2017
Synthesis of 3-acyl, methylene and epoxy substituted isoindolinone derivatives via the ortho-lithiation/cyclization procedures of aromatic imines with carbon monoxide
Fulltext Access 9 Pages 2017
Discovery of novel curcumin derivatives targeting xanthine oxidase and urate transporter 1 as anti-hyperuricemic agents
Fulltext Access 9 Pages 2017
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors
Fulltext Access 9 Pages 2017
Synthetic analogs of rhamnolipids modulate structured biofilms formed by rhamnolipid-nonproducing mutant of Pseudomonas aeruginosa
Fulltext Access 9 Pages 2017
Design and synthesis of novel photoinduced electron transfer-based hybridization probes
Fulltext Access 9 Pages 2017
Design, synthesis, and biological evaluation of some novel indolizine derivatives as dual cyclooxygenase and lipoxygenase inhibitor for anti-inflammatory activity
Fulltext Access 9 Pages 2017
Synthesis and biological evaluation of fluoro-substituted 3,4-dihydroquinazoline derivatives for cytotoxic and analgesic effects
Fulltext Access 9 Pages 2017
A fluorogenic native chemical ligation for assessing the role of distance in peptide-templated peptide ligation
Fulltext Access 9 Pages 2017
Reagent-free continuous thermal tert-butyl ester deprotection
Fulltext Access 9 Pages 2017
The discovery of fluazaindolizine: A new product for the control of plant parasitic nematodes
Fulltext Access 9 Pages 2017
Native protein hydrogels by dynamic boronic acid chemistry
Fulltext Access 9 Pages 2017
An efficient artificial molecular pump
Fulltext Access 9 Pages 2017
Encapsulation, controlled release, and antitumor efficacy of cisplatin delivered in liposomes composed of sterol-modified phospholipids
Fulltext Access 9 Pages 2017
Synthesis and characterization of thiophene-based push-pull chromophores for tuning the electrical and optical properties of surfaces with controlled SAM formation
Fulltext Access 9 Pages 2017
Recent developments of coumarin-containing derivatives and their anti-tubercular activity
Fulltext Access 9 Pages 2017
Synthesis and bioactivity investigation of quinone-based dimeric cationic triazolium amphiphiles selective against resistant fungal and bacterial pathogens
Fulltext Access 9 Pages 2017
Aminopurine and aminoquinazoline scaffolds for development of potential dengue virus inhibitors
Fulltext Access 9 Pages 2017
Design and synthesis of conformationally constrained salinomycin derivatives
Fulltext Access 9 Pages 2017
Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity
Fulltext Access 9 Pages 2017
Synthesis and biological effect of chrom-4-one derivatives as functional inhibitors of heat shock protein 27
Fulltext Access 9 Pages 2017
Synthesis and in vitro biological evaluation of novel quinazoline derivatives
Fulltext Access 9 Pages 2017
Iron-catalyzed selective oxidative arylation of phenols and biphenols
Fulltext Access 9 Pages 2017
Novel benzimidazolyl tetrahydroprotoberberines: Design, synthesis, antimicrobial evaluation and multi-targeting exploration
Fulltext Access 9 Pages 2017
Discovery and optimization of 2-pyridinone aminal integrase strand transfer inhibitors for the treatment of HIV
Fulltext Access 9 Pages 2017
Semi-quantitative models for identifying potent and selective transthyretin amyloidogenesis inhibitors
Fulltext Access 9 Pages 2017
Synthesis, estrogen receptor binding affinity and molecular docking of pyrimidine-piperazine-chromene and -quinoline conjugates
Fulltext Access 9 Pages 2017
Bifunctional bisphosphonate derivatives and platinum complexes with high affinity for bone hydroxyapatite
Fulltext Access 9 Pages 2017
Inactivation of bovine plasma amine oxidase by 1,1,1-trihalo-3-aminopropanes
Fulltext Access 9 Pages 2017
Direct detection of nano-scale extracellular vesicles derived from inflammation-triggered endothelial cells using surface plasmon resonance
Fulltext Access 9 Pages 2017
System with embedded drug release and nanoparticle degradation sensor showing efficient rifampicin delivery into macrophages
Fulltext Access 9 Pages 2017
Antibacterial silk fibroin/nanohydroxyapatite hydrogels with silver and gold nanoparticles for bone regeneration
Fulltext Access 9 Pages 2017
Programmable carbon nanotube membrane-based transdermal nicotine delivery with microdialysis validation assay
Fulltext Access 9 Pages 2017
Regulation of immune-related diseases by multiple factors of chromatin, exosomes, microparticles, vaccines, oxidative stress, dormancy, protein quality control, inflammation and microenvironment: a meeting report of 2017 International Workshop of the Chin
Fulltext Access 9 Pages 2017
Effect of hyaluronic acid-binding to lipoplexes on intravitreal drug delivery for retinal gene therapy
Fulltext Access 9 Pages 2017
Monoacyl phosphatidylcholine inhibits the formation of lipid multilamellar structures during in vitro lipolysis of self-emulsifying drug delivery systems
Fulltext Access 9 Pages 2017
Fluoride loaded polymeric nanoparticles for dental delivery
Fulltext Access 9 Pages 2017
Korean medicine clinical practice guideline for lumbar herniated intervertebral disc in adults: An evidence based approach
Fulltext Access 9 Pages 2017
Exploring the current working profiles of nutritional therapists to inform curriculum and professional development
Fulltext Access 9 Pages 2017
The benefit/risk balance of subcutaneous injections as used in homeopathy and anthroposophic medicine: A narrative literature review
Fulltext Access 9 Pages 2017
Generation of human pluripotent stem cell-derived hepatocyte-like cells for drug toxicity screening
Fulltext Access 9 Pages 2017
A survey of pharmacists' knowledge and views of biosimilars in Quebec and France
Fulltext Access 9 Pages 2017
How to unleash mitochondrial apoptotic blockades to kill cancers?
Fulltext Access 9 Pages 2017
Carbenoid transfer reactions catalyzed by a ruthenium porphyrin macrocycle
Fulltext Access 9 Pages 2017
Targeting tuberculosis using structure-guided fragment-based drug design
Fulltext Access 9 Pages 2017
Pharmaceutical and biomaterial engineering via electrohydrodynamic atomization technologies
Fulltext Access 9 Pages 2017
An improved hybrid of particle swarm optimization and the gravitational search algorithm to produce a kinetic parameter estimation of aspartate biochemical pathways
Fulltext Access 9 Pages 2017
Graphical abstracts
Fulltext Access 9 Pages 2017
Regioselective and efficient halogenation of 4,5-unsubstituted alkyl 3-hydroxypyrrole/3-hydroxythiophene-2-yl-carboxylates
Fulltext Access 9 Pages 2017
Synthesis of substituted benzofurans and indoles by Zn-catalyzed tandem Sonogashira-cyclization strategy
Fulltext Access 9 Pages 2017
Two unusual isoflavonoids from Campylotropis hirtella - A new biosynthesis route of flavonoids
Fulltext Access 9 Pages 2017
Metal-free sulfonylation of quinones with sulfonyl hydrazides in water: Facile access to mono-sulfonylated hydroquinones
Fulltext Access 9 Pages 2017
Synthesis of monovinyl- and divinyl-chlorophyll analogs and their physical properties
Fulltext Access 9 Pages 2017
An efficient, scalable approach to hydrolyze flavonoid glucuronides via activation of glycoside bond
Fulltext Access 9 Pages 2017
Graphical contents list
Fulltext Access 10 Pages 2017
Novel, highly potent systemic glucokinase activators for the treatment of Type 2 Diabetes Mellitus
Fulltext Access 10 Pages 2017
Synthesis and cell imaging applications of fluorescent mono/di/tri-heterocyclyl-2,6-dicyanoanilines
Fulltext Access 10 Pages 2017
Imidazopyridine-fused [1,3]-diazepinones part 2: Structure-activity relationships and antiproliferative activity against melanoma cells
Fulltext Access 10 Pages 2017
Resolution, absolute configuration and antifilarial activity of coumarinyl amino alcohols
Fulltext Access 10 Pages 2017
Clementine juice has the potential for drug interactions - In vitro comparison with grapefruit and mandarin juice
Fulltext Access 10 Pages 2017
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