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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Wittig-Horner mediated synthesis of 4-vinyl sulfide derivatives of pyrazoles
Fulltext Access 5 Pages 2016
Transition-metal-free hydroboration of terminal alkynes activated by base
Fulltext Access 5 Pages 2016
A simple one-pot synthesis of quinoline-4-carboxylic acids by the Pfitzinger reaction of isatin with enaminones in water
Fulltext Access 5 Pages 2016
Acetylene-free synthesis of vinyloxy pyridine and quinoline
Fulltext Access 5 Pages 2016
Coumarin based novel ligands in the Suzuki-Miyaura and Mizoroki-Heck cross-couplings under aqueous medium
Fulltext Access 5 Pages 2016
Microwave-assisted organocatalysis: phosphine-mediated Tomita Zipper cyclization affording functionalized spirooxindole
Fulltext Access 5 Pages 2016
Improved synthesis of electron deficient bipyridines
Fulltext Access 5 Pages 2016
A new fluorescence chemosensor for selective detection of copper ion in aqueous solution
Fulltext Access 5 Pages 2016
Square [5]molecular necklace formed from cucurbit[8]uril and carbazole derivative
Fulltext Access 5 Pages 2016
One-pot synthesis of 2-ferrocenyl-substituted pyridines
Fulltext Access 5 Pages 2016
Synthesis, mesomorphism and fluorescence of triphenylene-Bodipy dyads
Fulltext Access 5 Pages 2016
A framework for modeling information propagation of biological systems at critical states
Fulltext Access 5 Pages 2016
Concise and highly stereoselective syntheses of d-fagomine and 2-epi-fagomine
Fulltext Access 5 Pages 2016
Construction of turmerone motif-fused spiropyrrolidine oxindoles and their biological evaluation for anticancer activities
Fulltext Access 5 Pages 2016
Recyclable soluble polyisobutylene-bound oxidizing agents
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Cobalt-catalyzed oxidative cyclization of gem-disubstituted conjugated alkenols
Fulltext Access 5 Pages 2016
Negative activation energies for carbene additions to tetramethoxyethylene
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Palladium and copper catalyzed Sonogashira decarboxylative coupling of aryl iodides and alkynyl carboxylic acids
Fulltext Access 5 Pages 2016
Rapid construction of imidazopyridines from ortho-haloaminopyridines
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New synthetic strategy for chiral 2-oxazolidinones derivatives via rhodium-catalyzed asymmetric hydrogenation
Fulltext Access 5 Pages 2016
Development of a simple system for the oxidation of electron-rich diazo compounds to ketones
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Dithiocarbamates as an efficient intermediate for the synthesis of 2-(alkylsulfanyl)thiazoles in water
Fulltext Access 5 Pages 2016
Substitution nitrogen for chlorine of heptamethine cyanines for large Stokes shift fluorescent probes
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A double branched photosensitive prodrug: synthesis and characterization of light triggered drug release
Fulltext Access 5 Pages 2016
Epoxide and cyclic carbonate with diisononyl succinate backbone as phthalate-free plasticizers
Fulltext Access 5 Pages 2016
An efficient one-pot protocol for the conversion of benzaldehydes into tetrazole analogs
Fulltext Access 5 Pages 2016
Local conditions for global stability in the space of codons of the genetic code
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Exact numerical calculation of fixation probability and time on graphs
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PerspectiveFeatureHave many estimates of efficacy and affinity been misled? Revisiting the operational model of agonism
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Filtering promiscuous compounds in early drug discovery: is it a good idea?
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Exogenous nucleosome-binding molecules: a potential new class of therapeutic drugs
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Repurposing historical control clinical trial data to provide safety context
Fulltext Access 5 Pages 2016
Stable and reusable platinum nanocatalyst: an efficient chemoselective reduction of nitroarenes in water
Fulltext Access 5 Pages 2016
New access to quaternary aminocyclobutanes via nucleophilic addition on cyclobutaniminium salts
Fulltext Access 5 Pages 2016
Facile Pd-catalyzed chemoselective transfer hydrogenation of olefins using formic acid in water
Fulltext Access 5 Pages 2016
Nickel-catalyzed oxidative decarboxylative coupling reactions between alkynyl carboxylic acids and arylboronic acids
Fulltext Access 5 Pages 2016
Efficient nickel-catalyzed hydrocyanation of alkenes using acetone cyanohydrin as a safer cyano source
Fulltext Access 5 Pages 2016
A selective fluorescent and colorimetric probe for cyanide based on dual-site controlled intramolecular charge transfer-photoinduced electron transfer-Fluorescence resonance energy transfer
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Straightforward approach to norbornene core based chiral ligands by tandem cross dehydrogenative coupling reactions
Fulltext Access 5 Pages 2016
A silver triflate-catalyzed cascade of in situ-oxidation and allylation of arylbenzylamines
Fulltext Access 5 Pages 2016
Azobenzene-bridged bile acid dimers: an interesting class of conjugates with conformation-controlled bioactivity
Fulltext Access 5 Pages 2016
Supramolecular detection of geometrical differences of azobenzene carboxylates
Fulltext Access 5 Pages 2016
Efficient alkylation of cyclic silyl enol ethers by diarylmethylium salts
Fulltext Access 5 Pages 2016
Synthesis of bromodifluoromethyl(arylsulfonyl) compounds and microwave-assisted nickel catalyzed cross coupling with arylboronic acids
Fulltext Access 5 Pages 2016
Identification of an unexpected shunt pathway product provides new insights into tirandamycin biosynthesis
Fulltext Access 5 Pages 2016
Oxidative amination of benzylic alkanes with nitrobenzene derivatives as nitrogen sources
Fulltext Access 5 Pages 2016
An efficient route for the synthesis of benzimidazoles via a hydrogen-transfer strategy between o-nitroanilines and alcohols
Fulltext Access 5 Pages 2016
Dual oxidation/bromination of alkylbenzenes
Fulltext Access 5 Pages 2016
Design, synthesis and photoisomerization behavior of novel azobenzene-based dyes containing different alkyl chains and isolation groups
Fulltext Access 6 Pages 2016
Development of polymer-supported chiral aminoalcohols derived from biomass and their application to asymmetric alkylation
Fulltext Access 6 Pages 2016
Semisynthesis of membrane-anchored cholesteryl lipoproteins on live cell surface by azide-alkyne click reaction
Fulltext Access 6 Pages 2016
Total synthesis of diverse oxygenated carbazoles by modified aromatization using molecular iodine
Fulltext Access 6 Pages 2016
Catalytic carbon-carbon sigma-bond hydrogenolysis
Fulltext Access 6 Pages 2016
Application of natural feedstock extract: the Henry reaction
Fulltext Access 6 Pages 2016
Desymmetrization of acid anhydride with asymmetric esterification catalyzed by chiral phosphoric acid
Fulltext Access 6 Pages 2016
Bioisosteric modification of flavaglines
Fulltext Access 6 Pages 2016
Metal-free synthesis of highly substituted quinolines under mild conditions
Fulltext Access 6 Pages 2016
Copper-catalyzed one-pot tandem synthesis of unsymmetrical diaryl chalcogenides from two different aryl iodides
Fulltext Access 6 Pages 2016
Biodegradable choline hydroxide promoted environmentally benign thiolysis of epoxides
Fulltext Access 6 Pages 2016
Synthesis of novel and conformationally constrained bridged amino acids as compact modules for drug discovery
Fulltext Access 6 Pages 2016
Catalytic asymmetric synthesis of the common amino acid component in the biosynthesis of tetrahydroisoquinoline alkaloids
Fulltext Access 6 Pages 2016
Silver-catalyzed one-step synthesis of multiply substituted quinolines
Fulltext Access 6 Pages 2016
Spike-timing-dependent plasticity enhanced synchronization transitions induced by autapses in adaptive Newman-Watts neuronal networks
Fulltext Access 6 Pages 2016
Local community detection as pattern restoration by attractor dynamics of recurrent neural networks
Fulltext Access 6 Pages 2016
Matched analysis on orphan drug designations and approvals: cross regional analysis in the United States, the European Union, and Japan
Fulltext Access 6 Pages 2016
Targeting fatty acid metabolism in heart failure: is it a suitable therapeutic approach?
Fulltext Access 6 Pages 2016
The changing model of big pharma: impact of key trends
Fulltext Access 6 Pages 2016
Designing and incorporating a real world data approach to international drug development and use: what the UK offers
Fulltext Access 6 Pages 2016
The common marmoset as an indispensable animal model for immunotherapy development in multiple sclerosis
Fulltext Access 6 Pages 2016
Influence factors on the correlations between expression levels of neighboring pattern genes
Fulltext Access 6 Pages 2016
A fluorescein-based fluorescence probe for the fast detection of thiol
Fulltext Access 6 Pages 2016
Total synthesis of isocladosporin and 3-epi-isocladosporin
Fulltext Access 6 Pages 2016
Copper nanoparticles on charcoal: an effective nanocatalyst for the synthesis of enol carbamates and amides via an oxidative coupling route
Fulltext Access 6 Pages 2016
Microwave-assisted direct esterification of cyclic phosphinic acids in the presence of ionic liquids
Fulltext Access 6 Pages 2016
Two-directional carbon chain elongation via the consecutive 1,4-addition of allyl malononitrile and the Cope rearrangement on an alkynoate platform
Fulltext Access 6 Pages 2016
An off-the-shelf sensor for colourimetric detection of sulfide
Fulltext Access 6 Pages 2016
Synthesis and characterizations of a highly sensitive and selective fluorescent probe for hydrogen sulfide
Fulltext Access 6 Pages 2016
Copper-catalyzed oxidative molecular transformation of amidines for synthesis of nitrogen heterocycles
Fulltext Access 6 Pages 2016
Deep eutectic solvent as a highly efficient reaction media for the one-pot synthesis of benzo-fused seven-membered heterocycles
Fulltext Access 6 Pages 2016
Fast colorimetric titration protocol for quantification of boron tribromide
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Base-acid-induced translational isomerism in a branched [4]rotaxane
Fulltext Access 6 Pages 2016
Synthesis of highly water-soluble trisulfonated phthalocyanine with single carboxylic acid via palladium-catalyzed cyanation reaction
Fulltext Access 6 Pages 2016
Studies on the mechanism of quaternization of the catharanthine part of vinblastine and vincristine
Fulltext Access 6 Pages 2016
Baker's yeast as an efficient biocatalyst for regioselective 1,4-conjugate addition of indoles to nitroolefins in aqueous medium
Fulltext Access 6 Pages 2016
Impact of microwave irradiation on enzymatic activity at constant bulk temperature is enzyme-dependent
Fulltext Access 6 Pages 2016
Synthetic study of strongylophorines: stereoselective construction of the characteristic lactone bridge
Fulltext Access 6 Pages 2016
Catalyst-controlled regiodivergent vinylogous aza-Morita-Baylis-Hillman reactions
Fulltext Access 6 Pages 2016
Pamam built-on-silicon wafer thin-layer extraction devices for selective metal contamination detection
Fulltext Access 6 Pages 2016
A simple complex: 'on-off-on' colorimetric and ratiometric fluorescence response towards fluoride ions and its solid state optical properties
Fulltext Access 6 Pages 2016
A multicomponent access to 1,3-thiazine-6-phenylimino-5-carboxylates
Fulltext Access 6 Pages 2016
Isomeric chiral pyrrole diamides and their efficacy in enantioselective sensing of tartrate in sol-gel medium
Fulltext Access 6 Pages 2016
Facile synthesis of norwogonin, isoscutellarein, and herbacetin
Fulltext Access 6 Pages 2016
Metal-free synthesis of sulfonamides via iodine-catalyzed oxidative coupling of sulfonyl hydrazides and amines
Fulltext Access 6 Pages 2016
Triacetic acid lactone as a common intermediate for the synthesis of 4-hydroxy-2-pyridones and 4-amino-2-pyrones
Fulltext Access 6 Pages 2016
An improved and efficient strategy for the total synthesis of a colistin-like peptide
Fulltext Access 6 Pages 2016
Regioselective propargylation of aldehydes using potassium allenyltrifluoroborate promoted by tonsil
Fulltext Access 6 Pages 2016
Facile synthesis of 3-substituted isoindolinones
Fulltext Access 6 Pages 2016
Silica sodium carbonate catalyzed in water synthesis of novel benzylbarbiturocoumarin derivatives
Fulltext Access 6 Pages 2016
An efficient one pot three component synthesis of fused pyridines via electrochemical approach
Fulltext Access 6 Pages 2016
Molecular hybridization-guided 1,3-dipolar cycloaddition reaction enabled pyrimidine-fused spiropyrrolidine oxindoles synthesis as potential anticancer agents
Fulltext Access 6 Pages 2016
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