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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Graphical contents list
Fulltext Access 4 Pages 2016
Graphical contents list
Fulltext Access 4 Pages 2016
Synthesis and evaluation of phenylalanine-derived trifluoromethyl ketones for peptide-based oxidation catalysis
Fulltext Access 4 Pages 2016
Graphical contents list
Fulltext Access 4 Pages 2016
Graphical contents list
Fulltext Access 4 Pages 2016
Synthesis of a norcantharidin-tethered guanosine: Protein phosphatase-1 inhibitors that change alternative splicing
Fulltext Access 4 Pages 2016
Platelet mimicry: The emperor's new clothes?
Fulltext Access 4 Pages 2016
Recent developments in agrochemistry
Fulltext Access 4 Pages 2016
New steroidal saponins with cytotoxic activities from Smilax trinervula
Fulltext Access 5 Pages 2016
Oxidative rearrangement strategy for synthesis of 2,4,5-trisubstituted oxazoles utilizing hypervalent iodine reagent
Fulltext Access 5 Pages 2016
Occurrence of non-heterocyclic resveratrol tetramer in Vatica chinensis
Fulltext Access 5 Pages 2016
A red-emitting fluorescent probe for biothiols detection with a large Stokes shift
Fulltext Access 5 Pages 2016
Reduction of diphenylacetylene using Al powder in the presence of noble metal catalysts in water
Fulltext Access 5 Pages 2016
Base-catalyzed hydrogen–deuterium exchange and dehalogenation reactions of 1,2,3-triazole derivatives
Fulltext Access 5 Pages 2016
Ionic liquids as a reusable media for copper catalysis. Green access to alkenes using catalytic olefination reaction
Fulltext Access 5 Pages 2016
Synthesis, photophysical and electrochemical properties of symmetric silicon-linked coumarin-oxadiazole derivatives
Fulltext Access 5 Pages 2016
Direct synthesis of thiophosphates by reaction of diphenylphosphine oxide with sulfonyl chlorides
Fulltext Access 5 Pages 2016
Facile synthesis of 1,3-thiazolidin-4-ones as antitubercular agents
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Herbivore-induced volatile organic compounds emitted by maize: Electrophysiological responses in Spodoptera frugiperda females
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Cytotoxic and antimalarial constituents from the roots of Toddalia asiatica
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Synthesis and enantiomeric recognition studies of optically active 5,5-dioxophenothiazine bis(urea) and bis(thiourea) derivatives
Fulltext Access 5 Pages 2016
Development of curcumin–cyclodextrin/cellulose nanocrystals complexes: New anticancer drug delivery systems
Fulltext Access 5 Pages 2016
Synthesis, anti-inflammatory, ulcerogenic and cyclooxygenase activities of indenopyrimidine derivatives
Fulltext Access 5 Pages 2016
Synthesis, antimicrobial activity of Schiff base compounds of cinnamaldehyde and amino acids
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The semi-synthesis of novel andrographolide analogues and anti-influenza virus activity evaluation of their derivatives
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Carbamate substituted 2-amino-4,6-diphenylpyrimidines as adenosine receptor antagonists
Fulltext Access 5 Pages 2016
Design and synthesis of sarolaner, a novel, once-a-month, oral isoxazoline for the control of fleas and ticks on dogs
Fulltext Access 5 Pages 2016
Discovery of boronic acid-based fluorescent probes targeting amyloid-beta plaques in Alzheimer’s disease
Fulltext Access 5 Pages 2016
Carbon nanodots as molecular scaffolds for development of antimicrobial agents
Fulltext Access 5 Pages 2016
Novel nucleoside-based antimalarial compounds
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Synthesis of novel ethyl 1-ethyl-6-fluoro-7-(fatty amido)-1,4-dihydro-4-oxoquinoline-3-carboxylate derivatives and their biological evaluation
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Graphical contents list
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Design and evaluation of novel oxadiazole derivatives as potential prostate cancer agents
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The self-assembly of a camptothecin-lysine nanotube
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Development of novel proteasome inhibitors based on phthalazinone scaffold
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Synthesis, structure and antimicrobial evaluation of a new gossypol triazole conjugates functionalized with aliphatic chains and benzyloxy groups
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Design, synthesis and biological evaluation of photoaffinity probes of antiangiogenic homoisoflavonoids
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Synthesis and biological evaluation of matrine derivatives as anti-hepatocellular cancer agents
Fulltext Access 5 Pages 2016
Self-assembling tryptophan-based designer peptides as intracellular delivery vehicles
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Synthesis and biological activity of diisothiocyanate-derived mercapturic acids
Fulltext Access 5 Pages 2016
Synthesis and fluorescent study of 5-phenyl furocoumarin derivatives as vasodilatory agents
Fulltext Access 5 Pages 2016
Bifunctional primary amine 2-aminobenzimidazole organocatalyst anchored to trans-cyclohexane-1,2-diamine in enantioselective conjugate additions of aldehydes
Fulltext Access 5 Pages 2016
Synthesis of a new inhibitor of breast cancer resistance protein with significantly improved pharmacokinetic profiles
Fulltext Access 5 Pages 2016
Design, synthesis and in vivo screening of some novel quinazoline analogs as anti-hyperlipidemic and hypoglycemic agents
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Increase of rutin antioxidant activity by generating Maillard reaction products with lysine
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Synthesis and biological evaluation of aryloxyacetamide derivatives as neuroprotective agents
Fulltext Access 5 Pages 2016
New ligands of the ghrelin receptor based on the 1,2,4-triazole scaffold by introduction of a second chiral center
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(7-Diethylaminocoumarin-4-yl)methyl ester of suberoylanilide hydroxamic acid as a caged inhibitor for photocontrol of histone deacetylase activity
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Cost-effectiveness: A challenge for dengue rapid nanodiagnostic tests
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Novel method of simultaneous multiple immunogold localization on resin sections in high resolution scanning electron microscopy
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Surprising lack of liposome-induced complement activation by artificial 1,3-diamidophospholipids in vitro
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A cell-based approach to characterize antimicrobial compounds through kinetic dose response
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Design and synthesis of novel hybrid sydnonimine and prodrug useful for glaucomatous optic neuropathy
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One-pot synthesis and antifungal activity against plant pathogens of quinazolinone derivatives containing an amide moiety
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Synthesis and docking studies of pyrazine–thiazolidinone hybrid scaffold targeting dormant tuberculosis
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Evaluation of bisbenzamidines as inhibitors for matriptase-2
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Rational design and synthesis of novel anti-prostate cancer agents bearing a 3,5-bis-trifluoromethylphenyl moiety
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Synthesis of lignan conjugates via cyclopropanation: Antimicrobial and antioxidant studies
Fulltext Access 5 Pages 2016
Synthesis and cytotoxic activities of semisynthetic zearalenone analogues
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Design, synthesis, and evaluation of water-soluble morpholino-decorated paclitaxel prodrugs with remarkably decreased toxicity
Fulltext Access 5 Pages 2016
An evolved oxazolidinone with selective potency against Mycobacterium tuberculosis and gram positive bacteria
Fulltext Access 5 Pages 2016
Synthesis, characterization and anti-cancer activity of a peptide nucleolipid bioconjugate
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Kinetic investigation of human 5-lipoxygenase with arachidonic acid
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Design and optimization of tricyclic gamma-secretase modulators
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Identification of new quinic acid derivatives as histone deacetylase inhibitors by fluorescence-based cellular assay
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The natural flavone fukugetin as a mixed-type inhibitor for human tissue kallikreins
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Carbohydrate-based inducers of cellular stress for targeting cancer cells
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Anti-inflammatory and antioxidant properties of a novel resveratrol–salicylate hybrid analog
Fulltext Access 5 Pages 2016
Antibacterial and antifungal activities of 2,3-pyrrolidinedione derivatives against oral pathogens
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Functional foldamers that target bacterial membranes: The effect of charge, amphiphilicity and conformation
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Incorporation of fluorophore–cholesterol conjugates into liposomal and mycobacterial membranes
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Synthesis and asymmetric resolution of a dopaminergic compound: 2-amino-5-methoxyindane
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Lipase kinetic enantiomeric resolution of 1-heteroarylethanols
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Synthesis and study of the structural properties of oxa[5]helicene derivatives
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A chiral, bis-anthraquinone-bridged cyclophane with a large specific rotation
Fulltext Access 5 Pages 2016
Chiral copper-catalyzed asymmetric monoarylation of vicinal diols with diaryliodonium salts
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Pyridazinone substituted benzenesulfonamides as potent carbonic anhydrase inhibitors
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Biological evaluation and molecular docking studies of new curcuminoid derivatives: Synthesis and characterization
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Optimization of isoxazoline amide benzoxaboroles for identification of a development candidate as an oral long acting animal ectoparasiticide
Fulltext Access 5 Pages 2016
Synthesis and anti-proliferative activity of fluoro-substituted chalcones
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Sequential one-pot synthesis of bis(indolyl)glyoxylamides: Evaluation of antibacterial and anticancer activities
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Quinazolinones–Phenylquinoxaline hybrids with unsaturation/saturation linkers as novel anti-proliferative agents
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Solubility-driven lead optimisation: Recent examples and personal perspectives
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Synthesis, biological evaluation and molecular docking of 2-phenyl-benzo[d]oxazole-7-carboxamide derivatives as potential Staphylococcus aureus Sortase A inhibitors
Fulltext Access 5 Pages 2016
Cationic lioposomes with folic acid as targeting ligand for gene delivery
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Antioxidant properties of thio-caffeine derivatives: Identification of the newly synthesized 8-[(pyrrolidin-1-ylcarbonothioyl)sulfanyl]caffeine as antioxidant and highly potent cytoprotective agent
Fulltext Access 5 Pages 2016
Synthesis and evaluation of novel 1,2,3-triazole-based acetylcholinesterase inhibitors with neuroprotective activity
Fulltext Access 5 Pages 2016
Antitumor activities of biscoumarin and dihydropyran derivatives
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Novel prodrugs with a spontaneous cleavable guanidine moiety
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Inhibition of monoamine oxidase by benzoxathiolone analogues
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Polycyclic amines as chloroquine resistance modulating agents in Plasmodium falciparum
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Synthesis and activity of benzimidazole-1,3-dioxide inhibitors of separase
Fulltext Access 5 Pages 2016
Synthesis and in vitro evaluation of water-soluble 1,4-diphenethylpiperazine analogs as novel inhibitors of the vesicular monoamine transporter-2
Fulltext Access 5 Pages 2016
Design, synthesis, and protein methyltransferase activity of a unique set of constrained amine containing compounds
Fulltext Access 5 Pages 2016
Development of indole sulfonamides as cannabinoid receptor negative allosteric modulators
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Suppression of store overload-induced calcium release by hydroxylated metabolites of carvedilol
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Diversification of edaravone via palladium-catalyzed hydrazine cross-coupling: Applications against protein misfolding and oligomerization of beta-amyloid
Fulltext Access 5 Pages 2016
Synthesis and biological evaluation of a novel artesunate–podophyllotoxin conjugate as anticancer agent
Fulltext Access 5 Pages 2016
Photoactivatable protein labeling by singlet oxygen mediated reactions
Fulltext Access 5 Pages 2016
Synthesis, crystal structures, molecular docking, and in vitro biological activities of transition metals with 4-(2,3-dichlorophenyl)piperazine-1-carboxylic acid
Fulltext Access 5 Pages 2016
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