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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Synthesis of oxetane-3-carboxaldehyde and methyl oxetane-3-carboxylate via homologation of oxetane-3-one
Fulltext Access 6 Pages 2016
Computational Models of Neurological DisorderVirtual Brain for neurological disease modeling
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Peroxide-mediated direct synthesis of amides from aroyl surrogates
Fulltext Access 6 Pages 2016
Synthesis of original phosphine-sulfoxide ligands for asymmetric allylic alkylation
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Novel chiral thiourea organocatalysts for the catalytic asymmetric oxaziridination
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A novel host material with high thermal stability for green electrophosphorescent device
Fulltext Access 6 Pages 2016
A novel colorimetric and fluorescent probe for detecting fluoride anions: from water and toothpaste samples
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Simple approach to modular chiral scaffolds: binding functional sulfur nucleophiles to Cinchona alkaloids
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Rational construction of macrocycles consisting of methylene bridged ureas
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Self-assembling asymmetrical tripodal-like peptides as anion receptors
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Reversible capture and release of aromatic amines by vicinal tricarbonyl compound
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A convenient one-pot process for the synthesis of 2,4-dihydroxy-6-phenylethylenyl-8-deazapteridine derivatives
Fulltext Access 6 Pages 2016
Eco-friendly synthesis of 3-etherified estrones
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Translational PharmacologyTranslational pharmacokinetic/pharmacodynamic analysis in cancer pharmacology: a tool to maximize the value of antitumor efficacy from tumor bearing mice
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Poly[(9,9-dioctyl-fluorenyl-2,7-diyl)-co-fluorenone]-based orange fluorescence probe for cellular imaging
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Novel efficient functionalized tetrapyrazolic macrocycle for the selective extraction of lithium cations
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First catalytic asymmetric hydrogenation of quinoxaline-2-carboxylates
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A new ratiometric two-photon fluorescent probe for imaging of lysosomes in living cells and tissues
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Synthesis of two chiral octahydroindole scaffolds for drug discovery
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1,2,4-Triazole derivatives as host materials for blue and green phosphorescent organic light-emitting devices
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Compositional analysis of pretreated (beech) wood using differential scanning calorimetry and multivariate data analysis
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Hydrophobic microenvironment optimization for efficient immobilization of lipases on octadecyl functionalised resins
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Enzymatic profiling in prostate and breast cancer cells: phosphate hydrolysis and alcohol oxidation
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Expanding substrate scope of lipase-catalyzed transesterification by the utilization of liquid carbon dioxide
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General synthesis, structure, and optical properties of benzothiophene-fused benzoheteroles containing Group 15 and 16 elements
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Virtual liver models in pre-surgical planning, intra-surgical navigation and prognosis analysis
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Conformational stability and self-association equilibrium in biologics
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Characterization of antibody-drug conjugates by mass spectrometry: advances and future trends
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Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors
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Electron affinity of tricyclic, bicyclic, and monocyclic compounds containing cyanoenones correlates with their potency as inducers of a cytoprotective enzyme
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Synthesis of novel flavone derivatives possessing substituted benzamides and their biological evaluation against human cancer cells
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Cysteine and arginine-rich peptides as molecular carriers
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Development of a novel sulfonate ester-based prodrug strategy
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Development and structural analysis of adenosine site binding tankyrase inhibitors
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Kinetic controlled affinity labeling of target enzyme with thioester chemistry
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Design, synthesis, and biological evaluation of new arylamide derivatives possessing sulfonate or sulfamate moieties as steroid sulfatase enzyme inhibitors
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Modelling ageing and age-related disease
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Tools for exploring mouse models of human disease
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High-yield preparation of new crown ether-based cryptands and improving complexation with paraquat, paraquat derivatives and diquat
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Computational modelling of Hedgehog signalling in liver regeneration
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Towards knowledge-driven cross-species extrapolation
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Azide-enolate 1,3-dipolar cycloaddition in the synthesis of novel triazole-based miconazole analogues as promising antifungal agents
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Strategies for improving the solubility and metabolic stability of griseofulvin analogues
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Graphical contents list
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Synthesis and cytotoxicity of novel artemisinin derivatives containing sulfur atoms
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Discovery of novel free fatty acid receptor 1 agonists bearing triazole core via click chemistry
Fulltext Access 6 Pages 2016
Synthesis and biological evaluation of novel hydrogen sulfide releasing nicotinic acid derivatives
Fulltext Access 6 Pages 2016
Regulatory Incentives for Antibiotic Drug Development: A Review of Recent Proposals
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The emergence and evolution of antimicrobial resistance: Impact on a global scale
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Simulations reveal increased fluctuations in estrogen receptor-alpha conformation upon antagonist binding
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Preparation and characterization of the pH and thermosensitive magnetic molecular imprinted nanoparticle polymer for the cancer drug delivery
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Design and synthesis of selective, dual fatty acid binding protein 4 and 5 inhibitors
Fulltext Access 6 Pages 2016
Discovery of anabaenopeptin 679 from freshwater algal bloom material: Insights into the structure-activity relationship of anabaenopeptin protease inhibitors
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Synthesis and biological evaluation of lovastatin-derived aliphatic hydroxamates that induce reactive oxygen species
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AntihypoxamiR functionalized gramicidin lipid nanoparticles rescue against ischemic memory improving cutaneous wound healing
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Graphical contents list
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Benzylamide antagonists of protease activated receptor 2 with anti-inflammatory activity
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In silico exploration for agonists/antagonists of brassinolide
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Design and synthesis of novel hydroxypyridinone derivatives as potential tyrosinase inhibitors
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Cholinesterase inhibitory activity of chlorophenoxy derivatives—Histamine H3 receptor ligands
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Synthesis of linear and cyclic peptide–PEG–lipids for stabilization and targeting of cationic liposome–DNA complexes
Fulltext Access 6 Pages 2016
Simple Nε-thioacetyl-lysine-containing cyclic peptides exhibiting highly potent sirtuin inhibition
Fulltext Access 6 Pages 2016
Quantitative relationships between structure and cytotoxic activity of flavonoid derivatives. An application of Hirshfeld surface derived descriptors
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Design and synthesis of fluorescent glycolipid photoaffinity probes and their photoreactivity
Fulltext Access 6 Pages 2016
2-Phenylbenzofuran derivatives as butyrylcholinesterase inhibitors: Synthesis, biological activity and molecular modeling
Fulltext Access 6 Pages 2016
Seeking potent anti-tubercular agents: Design, synthesis, anti-tubercular activity and docking study of various ((triazoles/indole)-piperazin-1-yl/1,4-diazepan-1-yl)benzo[d]isoxazole derivatives
Fulltext Access 6 Pages 2016
An evaluation of synthetic indole derivatives as inhibitors of monoamine oxidase
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Design and synthesis of novel quinoxaline derivatives as potential candidates for treatment of multidrug-resistant and latent tuberculosis
Fulltext Access 6 Pages 2016
Dioxol and dihydrodioxin analogs of 2- and 3-phenylacetonitriles as potent anti-cancer agents with nanomolar activity against a variety of human cancer cells
Fulltext Access 6 Pages 2016
Click-based synthesis and antitubercular evaluation of dibenzofuran tethered thiazolyl-1,2,3-triazolyl acetamides
Fulltext Access 6 Pages 2016
Identification of novel 2-aminothiazole conjugated nitrofuran as antitubercular and antibacterial agents
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Synthesis and antitubercular activity of new 1,3,4-oxadiazoles bearing pyridyl and thiazolyl scaffolds
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New insights into 3-(aminomethyl)naphthoquinones: Evaluation of cytotoxicity, electrochemical behavior and search for structure–activity correlation
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Hesperetin derivatives: Synthesis and anti-inflammatory activity
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New antibacterial isocoumarin glycosides from a wetland soil derived fungal strain Metarhizium anisopliae
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Radical arylation of tyrosine residues in peptides
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Copper-mediated alkylation of furan and thiophene derivatives with cyclic ethers
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Determination on temperature gradient of different polar reactants in reaction mixture under microwave irradiation with molecular probe
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Lipase-initiated one-pot synthesis of spirooxazino derivatives: redesign of multicomponent reactions to expand substrates scope and application potential
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An alternative approach to the synthesis of peptides containing a cystathionine bridge
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Diarylation of chalcogen elements using arylboronic acids via copper- or palladium-catalyzed oxidative coupling
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Nitrosocarbonyl release from O-substituted hydroxamic acids with pyrazolone leaving groups
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Direct, visible light-sensitized benzylic CH fluorination of peptides using dibenzosuberenone: selectivity for phenylalanine-like residues
Fulltext Access 6 Pages 2016
Base- and acid-catalyzed intramolecular oxy-Michael reaction for the synthesis of tetrahydrofuran ring
Fulltext Access 6 Pages 2016
Base-promoted domino reaction for the synthesis of 2,3-disubstituted indoles from 2-aminobenzaldehyde/2-amino aryl ketones, tosylhydrazine, and aromatic aldehydes
Fulltext Access 6 Pages 2016
Hemithioketal formation of vicinal tricarbonyl compound with thiols and their recovery
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New insights in the mechanism of the microwave-assisted Pauson-Khand reaction
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Highly selective oxidation of unsaturated hydrocarbons to carbonyl compounds by two-phase catalysis
Fulltext Access 6 Pages 2016
Design and synthesis of thiourea derivatives with sulfur-containing heterocyclic scaffolds as potential tyrosinase inhibitors
Fulltext Access 6 Pages 2016
Photochemical functionalization of diazines: metal-free vinylation and phosphonylation
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Intramolecular homolytic substitution in selenoxides and selenones
Fulltext Access 6 Pages 2016
Design of high-performance dye-sensitized solar cells by variation of the dihedral angles of dyes
Fulltext Access 6 Pages 2016
Ultraviolet-induced amides and casbene diterpenoids from rice leaves
Fulltext Access 6 Pages 2016
Synthesis and cytotoxic activity of boswellic acid analogues
Fulltext Access 6 Pages 2016
Diketopiperazine indole alkaloids from hemp seed
Fulltext Access 6 Pages 2016
Novel substituted aminothiazoles as potent and selective anti-hepatocellular carcinoma agents
Fulltext Access 6 Pages 2016
Novel bicyclo[3.1.0]hexane analogs as antagonists of metabotropic glutamate 2/3 receptors for the treatment of depression
Fulltext Access 6 Pages 2016
Synthesis and biological evaluation of chalcone derivatives containing aminoguanidine or acylhydrazone moieties
Fulltext Access 6 Pages 2016
Increasing metabolic stability via the deuterium kinetic isotope effect: An example from a proline-amide-urea aminothiazole series of phosphatidylinositol-3 kinase alpha inhibitors
Fulltext Access 6 Pages 2016
Lipoic acid functionalized amino acids cationic lipids as gene vectors
Fulltext Access 6 Pages 2016
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