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Daneshyari Drug Discovery Journas Latest Articles

Drug Discovery Research Articles

Isoniazid metabolism and hepatotoxicity
Fulltext Access 9 Pages 2016
Multi-facetted impulsivity following nigral degeneration and dopamine replacement therapy
Fulltext Access 9 Pages 2016
Causation model of autism: Audiovisual brain specialization in infancy competes with social brain networks
Fulltext Access 9 Pages 2016
Quantitative surface topography assessment of directly compressed and roller compacted tablet cores using photometric stereo image analysis
Fulltext Access 9 Pages 2016
Propensity of salicylamide and ethenzamide cocrystallization with aromatic carboxylic acids
Fulltext Access 9 Pages 2016
Development and evaluation of insulin-loaded cationic solid lipid nanoparticles for oral delivery
Fulltext Access 9 Pages 2016
Enhanced drug loading capacity of 10-hydroxycamptothecin-loaded nanoparticles prepared by two-step nanoprecipitation method
Fulltext Access 9 Pages 2016
Staging of fibrosis in experimental non-alcoholic steatohepatitis by quantitative molecular imaging in rat models
Fulltext Access 9 Pages 2016
The Ikaros family of zinc-finger proteins
Fulltext Access 9 Pages 2016
Selective chemical genetic inhibition of protein kinase C epsilon reduces ethanol consumption in mice
Fulltext Access 9 Pages 2016
Screening of synergistic interactions of epigallocatechin-3-gallate with antiangiogenic and antitumor compounds
Fulltext Access 9 Pages 2016
Social isolation rearing increases dopamine uptake and psychostimulant potency in the striatum
Fulltext Access 9 Pages 2016
Gabapentin potentiates sensitivity to the interoceptive effects of alcohol and increases alcohol self-administration in rats
Fulltext Access 9 Pages 2016
Benzonatate inhibition of voltage-gated sodium currents
Fulltext Access 9 Pages 2016
Adenosine receptors as markers of brain iron deficiency: Implications for Restless Legs Syndrome
Fulltext Access 9 Pages 2016
Is myopia another clinical manifestation of insulin resistance?
Fulltext Access 9 Pages 2016
Prediction of the Adsorption of Diazepam by Activated Carbon in Aqueous Media
Fulltext Access 9 Pages 2016
Development of Suberin Fatty Acids and Chloramphenicol-Loaded Antimicrobial Electrospun Nanofibrous Mats Intended for Wound Therapy
Fulltext Access 9 Pages 2016
Rapid Conformational Analysis of Protein Drugs in Formulation by Hydrogen/Deuterium Exchange Mass Spectrometry
Fulltext Access 9 Pages 2016
Preparation of a Novel Form of Gelatin With a Three-Dimensional Ordered Macroporous Structure to Regulate the Release of Poorly Water-Soluble Drugs
Fulltext Access 9 Pages 2016
Interlaboratory Validation of Small-Scale Solubility and Dissolution Measurements of Poorly Water-Soluble Drugs
Fulltext Access 9 Pages 2016
Solution and Solid State Nuclear Magnetic Resonance Spectroscopic Characterization of Efavirenz
Fulltext Access 9 Pages 2016
Physiologically Based Pharmacokinetic Modeling for Substitutability Analysis of Venlafaxine Hydrochloride Extended-Release Formulations Using Different Release Mechanisms: Osmotic Pump Versus Openable Matrix
Fulltext Access 9 Pages 2016
The Use of Binary Polymeric Networks in Stabilizing Polyethylene Oxide Solid Dispersions
Fulltext Access 9 Pages 2016
Novel Displacement Agents for Aqueous 2-Phase Extraction Can Be Estimated Based on Hybrid Shortcut Calculations
Fulltext Access 9 Pages 2016
Studying the Propensity of Compounds to Supersaturate: A Practical and Broadly Applicable Approach
Fulltext Access 9 Pages 2016
Non-Ablative Fractional Laser to Facilitate Transdermal Delivery
Fulltext Access 9 Pages 2016
Impact of pharmaceutical intervention on quality of life and coping strategies in patients with haematological malignancies
Fulltext Access 9 Pages 2016
A Nanoscale Polymeric Penetration Enhancer Based on Polylysine for Topical Delivery of Proteins and Peptides
Fulltext Access 9 Pages 2016
The Crystal Structure and Behavior of Fenamic Acid-Acridine Complex Under High Pressure
Fulltext Access 9 Pages 2016
Simple spectrophotometric methods for the simultaneous determination of antipyrine and benzocaine
Fulltext Access 9 Pages 2016
Canalization of genetic and pharmacological perturbations in developing primary neuronal activity patterns
Fulltext Access 9 Pages 2016
Invited reviewAdenosinergic signaling in epilepsy
Fulltext Access 9 Pages 2016
Dopamine dynamics and cocaine sensitivity differ between striosome and matrix compartments of the striatum
Fulltext Access 9 Pages 2016
The sigma-1 receptor-zinc finger protein 179 pathway protects against hydrogen peroxide-induced cell injury
Fulltext Access 9 Pages 2016
Inactivation of the lateral orbitofrontal cortex increases drinking in ethanol-dependent but not non-dependent mice
Fulltext Access 9 Pages 2016
Understanding Subcutaneous Tissue Pressure for Engineering Injection Devices for Large-Volume Protein Delivery
Fulltext Access 9 Pages 2016
Hepatic Clearance Prediction of Nine Human Immunodeficiency Virus Protease Inhibitors in Rat
Fulltext Access 9 Pages 2016
Development of a Novel Lung Slice Methodology for Profiling of Inhaled Compounds
Fulltext Access 9 Pages 2016
Mechanism of Decarboxylation of Pyruvic Acid in the Presence of Hydrogen Peroxide
Fulltext Access 9 Pages 2016
The Effect of Capsaicin Derivatives on Tight-Junction Integrity and Permeability of Madin-Darby Canine Kidney Cells
Fulltext Access 9 Pages 2016
Quality and Batch-to-Batch Consistency of Original and Biosimilar Epoetin Products
Fulltext Access 9 Pages 2016
Development of a Support Vector Machine-Based System to Predict Whether a Compound Is a Substrate of a Given Drug Transporter Using Its Chemical Structure
Fulltext Access 9 Pages 2016
Pharmacokinetic Modeling to Simulate the Concentration-Time Profiles After Dermal Application of Rivastigmine Patch
Fulltext Access 9 Pages 2016
Three-Dimensional Printing of Carbamazepine Sustained-Release Scaffold
Fulltext Access 9 Pages 2016
Influence of the Surface Acidity of the Alumina on the Sustained Release of Ketoprofen
Fulltext Access 9 Pages 2016
Population Pharmacokinetic-Toxicodynamic Modeling and Simulation of Cisplatin-Induced Acute Renal Injury in Rats: Effect of Dosing Rate on Nephrotoxicity
Fulltext Access 9 Pages 2016
Chemo-directed specific targeting of nanoparticle-doxorubicin complexes to tumor in animal model
Fulltext Access 9 Pages 2016
Use of interactive mixtures to obtain mini-tablets with high dose homogeneity for paediatric drug delivery
Fulltext Access 9 Pages 2016
Pravastatin-loaded chitosan nanoparticles: Formulation, characterization and cytotoxicity studies
Fulltext Access 9 Pages 2016
Synthesis of peppermint oil-loaded chitosan/alginate polyelectrolyte complexes and study of their antibacterial activity
Fulltext Access 9 Pages 2016
Enhanced solubility and intestinal absorption of cisplatin by coating with nano-hydroxyapatite
Fulltext Access 9 Pages 2016
Improving the dissolution rate of a poorly water-soluble drug via adsorption onto pharmaceutical diluents
Fulltext Access 9 Pages 2016
Black seed oil ameliorated scopolamine-induced memory dysfunction and cortico-hippocampal neural alterations in male Wistar rats
Fulltext Access 9 Pages 2016
X-ray crystallography, an essential tool for the determination of thermodynamic relationships between crystalline polymorphs
Fulltext Access 9 Pages 2016
Benzoic Acid and Chlorobenzoic Acids: Thermodynamic Study of the Pure Compounds and Binary Mixtures With Water
Fulltext Access 9 Pages 2016
Characterizing Reversible Protein Association at Moderately High Concentration Via Composition-Gradient Static Light Scattering
Fulltext Access 9 Pages 2016
A Micro-Polyethylene Glycol Precipitation Assay as a Relative Solubility Screening Tool for Monoclonal Antibody Design and Formulation Development
Fulltext Access 9 Pages 2016
A Simplified Model of Moisture Transport in Hydrophilic Porous Media With Applications to Pharmaceutical Tablets
Fulltext Access 9 Pages 2016
Protolytic Equilibria of Sartans in Micellar Solutions of Differently Charged Surfactants
Fulltext Access 9 Pages 2016
Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges
Fulltext Access 9 Pages 2016
Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 3. Oral Drug Products
Fulltext Access 9 Pages 2016
Quality by Design Approaches to Formulation Robustness-An Antibody Case Study
Fulltext Access 9 Pages 2016
Process and Formulation Effects on Protein Structure in Lyophilized Solids Using Mass Spectrometric Methods
Fulltext Access 9 Pages 2016
Spectroscopic-Based Chemometric Models for Quantifying Low Levels of Solid-State Transitions in Extended Release Theophylline Formulations
Fulltext Access 9 Pages 2016
Intra-articular Administration of Chitosan Thermosensitive In Situ Hydrogels Combined With Diclofenac Sodium-Loaded Alginate Microspheres
Fulltext Access 9 Pages 2016
Synergistic Skin Penetration Enhancer and Nanoemulsion Formulations Promote the Human Epidermal Permeation of Caffeine and Naproxen
Fulltext Access 9 Pages 2016
Acute food deprivation enhances fear extinction but inhibits long-term depression in the lateral amygdala via ghrelin signaling
Fulltext Access 10 Pages 2016
The Density Code for the Development of a Vaccine?
Fulltext Access 10 Pages 2016
A novel formulation for solubility and content uniformity enhancement of poorly water-soluble drugs using highly-porous mannitol
Fulltext Access 10 Pages 2016
Apoptosis and necroptosis induced by stenodactylin in neuroblastoma cells can be completely prevented through caspase inhibition plus catalase or necrostatin-1
Fulltext Access 10 Pages 2016
Dissociation in control of physiological and behavioral responses to emotional stress by cholinergic neurotransmission in the bed nucleus of the stria terminalis in rats
Fulltext Access 10 Pages 2016
Calcium channel genes associated with bipolar disorder modulate lithium's amplification of circadian rhythms
Fulltext Access 10 Pages 2016
Development and in vitro evaluation of core–shell type lipid–polymer hybrid nanoparticles for the delivery of erlotinib in non-small cell lung cancer
Fulltext Access 10 Pages 2016
In vitro release studies of insulin from lipid implants in solution and in a hydrogel matrix mimicking the subcutis
Fulltext Access 10 Pages 2016
Site- and species-specific hydrolysis rates of heroin
Fulltext Access 10 Pages 2016
Development and evaluation of wound healing hydrogels based on a quinolone, hydroxypropyl methylcellulose and biodegradable microfibres
Fulltext Access 10 Pages 2016
A longitudinal study of iris parameters and their relationships with temperament characteristics
Fulltext Access 10 Pages 2016
Pharmacokinetic considerations of nanodelivery to the brain: Using modeling and simulations to predict the outcome of liposomal formulations
Fulltext Access 10 Pages 2016
How lateral inhibition and fast retinogeniculo-cortical oscillations create vision: A new hypothesis
Fulltext Access 10 Pages 2016
Pharmacokinetics and pharmacodynamics study of rhein treating renal fibrosis based on metabonomics approach
Fulltext Access 10 Pages 2016
Safety and regulatory review of dyes commonly used as excipients in pharmaceutical and nutraceutical applications
Fulltext Access 10 Pages 2016
Development of protocatechualdehyde proliposomes-based sustained-release pellets with improved bioavailability and desired pharmacokinetic behavior for angina chronotherapy
Fulltext Access 10 Pages 2016
Effect of drug physicochemical properties on drug release and their relationship with drug skin permeation behaviors in hydroxyl pressure sensitive adhesive
Fulltext Access 10 Pages 2016
Regenerated cellulose capsules for controlled drug delivery: Part III. Developing a fabrication method and evaluating extemporaneous utility for controlled-release
Fulltext Access 10 Pages 2016
The development of a peak-time criterion for designing controlled-release devices
Fulltext Access 10 Pages 2016
Preclinical efficacy of a gastro-sparing novel thiazolidin-4-one in alleviating secondary lesions of polyarthritis: A multi-parametric approach
Fulltext Access 10 Pages 2016
Preparation and evaluation of chitosan-based nanogels/gels for oral delivery of myricetin
Fulltext Access 10 Pages 2016
Non-ablative fractional laser assists cutaneous delivery of small- and macro-molecules with minimal bacterial infection risk
Fulltext Access 10 Pages 2016
Subsistence-patterns, gender roles, effective temperature, and the evolutionary timing of a post reproductive life span
Fulltext Access 10 Pages 2016
Molecular and crystal structure of praziquantel. Spectroscopic properties and crystal polymorphism
Fulltext Access 10 Pages 2016
Evaluation of powder, solution and suspension layering for the preparation of enteric coated pellets
Fulltext Access 10 Pages 2016
Formulation and dissolution kinetics study of hydrophilic matrix tablets with tramadol hydrochloride and different co-processed dry binders
Fulltext Access 10 Pages 2016
Roller compaction scale-up using roll width as scale factor and laser-based determined ribbon porosity as critical material attribute
Fulltext Access 10 Pages 2016
Qingkailing injection for uncomplicated upper respiratory tract infection: A systematic review and meta-analysis
Fulltext Access 10 Pages 2016
Connecting the obesity and the narcissism epidemics
Fulltext Access 10 Pages 2016
A unifying hypothesis for hydrocephalus and the Chiari malformations part two: The hydrocephalus filling mechanism
Fulltext Access 10 Pages 2016
Cycles of insanity and creativity within contemplative neural systems
Fulltext Access 10 Pages 2016
Adipose-derived stem cells: A novel source of parathyroid cells for treatment of hypoparathyroidism
Fulltext Access 10 Pages 2016
Anabolic androgenic steroid-induced hepatotoxicity
Fulltext Access 10 Pages 2016
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