Amorphous Drug-PVP Dispersions: Application of Theoretical, Thermal and Spectroscopic Analytical Techniques to the Study of a Molecule With Intermolecular Bonds in Both the Crystalline and Pure Amorphous State Fulltext Access 13 Pages 2009
Porcine Buccal Mucosa as an In Vitro Model: Relative Contribution of Epithelium and Connective Tissue as Permeability Barriers Fulltext Access 13 Pages 2009
Physiological Models Are Good Tools to Predict Rat Bioavailability of EF5154 Prodrugs from In Vitro Intestinal Parameters Fulltext Access 13 Pages 2009
Sprayâdried carrierâfree dry powder tobramycin formulations with improved dispersion properties Fulltext Access 13 Pages 2009
Solid state chemistry of proteins IV. what is the meaning of thermal denaturation in freeze dried proteins? Fulltext Access 13 Pages 2009
Docetaxel-Albumin Conjugates: Preparation, In Vitro Evaluation and Biodistribution Studies Fulltext Access 13 Pages 2009
Informatic Calibration of a Materials Properties Database for Predictive Assessment of Mechanically Activated Disordering Potential for Small Molecule Organic Solids Fulltext Access 13 Pages 2009
Fabrication via a nonaqueous nanoprecipitation method, characterization and in vitro biological behavior of N6-cyclopentyladenosine-loaded nanoparticles Fulltext Access 13 Pages 2009
A pharmacoscintigraphic study of three time-delayed capsule formulations in healthy male volunteers Fulltext Access 13 Pages 2009
Differences in the interaction between aryl propionic acid derivatives and poly(vinylpyrrolidone) K30: A multi-methodological approach Fulltext Access 13 Pages 2009
Dry Powder Formulations for Inhalation of Fluticasone Propionate and Salmeterol Xinafoate Microcrystals Fulltext Access 13 Pages 2009
Non-Invasive Product Temperature Determination during Primary Drying using Tunable Diode Laser Absorption Spectroscopy Fulltext Access 13 Pages 2009
Effects of Micelles and Vesicles on the Oximolysis of pâNitrophenyl Diphenyl Phosphate: A Model System for SurfactantâBased SkinâDefensive Formulations against Organophosphates Fulltext Access 13 Pages 2009
Influence of Storage Relative Humidity on the Dispersion of Salmeterol Xinafoate Powders for Inhalation Fulltext Access 13 Pages 2009
No clinically relevant pharmacokinetic and safety interactions of ambrisentan in combination with tadalafil in healthy volunteers Fulltext Access 13 Pages 2009
Differential Involvement of P-Glycoprotein (ABCB1) in Permeability, Tissue Distribution, and Antinociceptive Activity of Methadone, Buprenorphine, and Diprenorphine: In Vitro and In Vivo Evaluation Fulltext Access 13 Pages 2009
Paracetamol-loaded poly(ε-caprolactone) layered silicate nanocomposites prepared using hot-melt extrusion Fulltext Access 13 Pages 2009
The role of mucoadhesion of trimethyl chitosan and PEGylated trimethyl chitosan nanocomplexes in insulin uptake Fulltext Access 13 Pages 2009
A new natural angelica polysaccharide based colon-specific drug delivery system Fulltext Access 13 Pages 2009
Protective activity of plicatin B against human LDL oxidation induced in metal ion-dependent and -independent processes. Experimental and theoretical studies Fulltext Access 13 Pages 2009
Investigation of critical polymer properties for polymer release and swelling of HPMC matrix tablets Fulltext Access 13 Pages 2009
Safeguarding against substandard/counterfeit drugs: Mitigating a macroeconomic pandemic Fulltext Access 13 Pages 2009
The effect of an educational intervention on patients' knowledge about hypertension, beliefs about medicines, and adherence Fulltext Access 13 Pages 2009
Pharmacists' communication with Spanish-speaking patients: A review of the literature to establish an agenda for future research Fulltext Access 13 Pages 2009
Characterization, selection, and development of an orally dosed drug polymorph from an enantiotropically related system Fulltext Access 13 Pages 2009
Pyridine induction of cytochrome P450 1A1, iNOS and metallothionein in Syrian hamsters and protective effects of silymarin Fulltext Access 13 Pages 2009
1st International ESTP Expert Workshop: “Larynx squamous metaplasia”. A re-consideration of morphology and diagnostic approaches in rodent studies and its relevance for human risk assessment Fulltext Access 13 Pages 2009
Suspected hepatotoxicity by Cimicifugae racemosae rhizoma (black cohosh, root): Critical analysis and structured causality assessment Fulltext Access 13 Pages 2009
Design, synthesis, and X-ray crystal structures of 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors Fulltext Access 13 Pages 2009
Factors that restrict intestinal cell permeation of cyclic prodrugs of an opioid peptide (DADLE): Part II. Role of metabolic enzymes in the intestinal mucosa Fulltext Access 13 Pages 2009
Controlled release of Repifermin® from polyelectrolyte complexes stimulates endothelial cell proliferation Fulltext Access 13 Pages 2009
Solid State Characterization and Crystal Structure from X-ray Powder Diffraction of Two Polymorphic Forms of Ranitidine Base Fulltext Access 13 Pages 2009
The Glass Transition and Sub-Tg-Relaxation in Pharmaceutical Powders and Dried Proteins by Thermally Stimulated Current Fulltext Access 13 Pages 2009
Common Excipients Impair Detection of Protein Aggregates During Sedimentation Velocity Analytical Ultracentrifugation Fulltext Access 13 Pages 2009
Peptide Derivation of Poorly Absorbable Drug Allows Intestinal Absorption Via Peptide Transporter Fulltext Access 13 Pages 2009
Characterization and Optimization of AMG 517 Supersaturatable SelfâEmulsifying Drug Delivery System (SâSEDDS) for Improved Oral Absorption Fulltext Access 13 Pages 2009
Inhibition of tRNA-dependent ligase MurM from Streptococcus pneumoniae by phosphonate and sulfonamide inhibitors Fulltext Access 13 Pages 2009
Influence of Plasma Protein Binding on Pharmacodynamics: Estimation of In Vivo Receptor Affinities of β Blockers Using a New Mechanism-Based PK-PD Modelling Approach Fulltext Access 13 Pages 2009
On the Mechanism and Dynamics of Uptake and Permeation of Polyether-Copolyester Dendrimers Across an In Vitro Blood-Brain Barrier Model Fulltext Access 13 Pages 2009
Development and Evaluation of Perfluorocarbon Nanobubbles for Apomorphine Delivery Fulltext Access 13 Pages 2009
The Role of Covalent Dimerization on the Physical and Chemical Stability of the EC1 Domain of Human E-Cadherin Fulltext Access 13 Pages 2009
Succinimide formation at Asn 55 in the complementarity determining region of a recombinant monoclonal antibody IgG1 heavy chain Fulltext Access 13 Pages 2009
A screening study of surface stabilization during the production of drug nanocrystals Fulltext Access 13 Pages 2009
Preparation, physiochemical characterization, and oral immunogenicity of Aβ(1-12), Aβ(29-40), and Aβ(1-42) loaded PLG microparticles formulations Fulltext Access 13 Pages 2009
Involvement of PI3K-Akt-Bad pathway in apoptosis induced by 2,6-di-O-methyl-β-cyclodextrin, not 2,6-di-O-methyl-α-cyclodextrin, through cholesterol depletion from lipid rafts on plasma membranes in cells Fulltext Access 13 Pages 2009
Skin penetration enhancement by a microneedle device (Dermaroller®) in vitro: Dependency on needle size and applied formulation Fulltext Access 13 Pages 2009
Miscibility/stability considerations in binary solid dispersion systems composed of functional excipients towards the design of multi-component amorphous systems Fulltext Access 13 Pages 2009
Vancomycin analogs: Seeking improved binding of d-Ala-d-Ala and d-Ala-d-Lac peptides by side-chain and backbone modifications Fulltext Access 13 Pages 2009
Analysis of binding parameters of HIV-1 integrase inhibitors: Correlates of drug inhibition and resistance Fulltext Access 13 Pages 2009
Synthesis and structure–activity relationships of C-glycosylated oxadiazoles as inhibitors of glycogen phosphorylase Fulltext Access 13 Pages 2009
Synthesis, structural characterisation and biological evaluation of fluorinated analogues of resveratrol Fulltext Access 13 Pages 2009
Importance of surface properties of affinity resin for capturing a target protein, Cyclooxygenase-1 Fulltext Access 13 Pages 2009
The flexibility of the LeaLex Tumor Associated Antigen central fragment studied by systematic and stochastic searches as well as dynamic simulations Fulltext Access 13 Pages 2009
Azole antimicrobial pharmacophore-based tetrazoles: Synthesis and biological evaluation as potential antimicrobial and anticonvulsant agents Fulltext Access 13 Pages 2009
Glucose-based spiro-isoxazolines: A new family of potent glycogen phosphorylase inhibitors Fulltext Access 13 Pages 2009
Synthesis and evaluation of novel α-heteroaryl-phenylpropanoic acid derivatives as PPARα/γ dual agonists Fulltext Access 13 Pages 2009
Synthesis, hydrolysis, and skin retention of amino acid esters of α-tocopherol Fulltext Access 13 Pages 2009
Preparation and characterization of negatively charged poly(lactic-co-glycolic acid) microspheres Fulltext Access 13 Pages 2009
Glycosylation of aromatic amines II: Kinetics and mechanisms of the hydrolytic reaction between kynurenine and glucose Fulltext Access 13 Pages 2009
Multivariate modeling of encapsulation and release of an ionizable drug from polymer microspheres Fulltext Access 13 Pages 2009
The effect of experimental hyperlipidemia on the stereoselective tissue distribution, lipoprotein association and microsomal metabolism of (±)-halofantrine Fulltext Access 13 Pages 2009
Quantitation of protein particles in parenteral solutions using micro-flow imaging Fulltext Access 14 Pages 2009
Cholesterol-Mediated Activation of P-Glycoprotein: Distinct Effects on Basal and Drug-Induced ATPase Activities Fulltext Access 14 Pages 2009
Mechanistic evaluation of alginate-HEC gelisphere compacts for controlled intrastriatal nicotine release in Parkinson's disease Fulltext Access 14 Pages 2009
Novel methods for the assessment of miscibility of amorphous drug-polymer dispersions Fulltext Access 14 Pages 2009
Solid state mechanochemical simultaneous activation of the constituents of the Silybum marianum phytocomplex with crosslinked polymers* Fulltext Access 14 Pages 2009
Impact of sucrose level on storage stability of proteins in freeze-dried solids: I. correlation of protein–sugar interaction with native structure preservation Fulltext Access 14 Pages 2009
Characterization of the photodegradation of a human IgG1 monoclonal antibody formulated as a high-concentration liquid dosage form Fulltext Access 14 Pages 2009
Polymorphism of Progesterone: Relative Stabilities of the Orthorhombic Phases I and II Inferred from Topological and Experimental Pressure-Temperature Phase Diagrams Fulltext Access 14 Pages 2009
Heterogeneity of Commercial Recombinant Human Growth Hormone (r-hGH) Preparations Containing a Thioether Variant Fulltext Access 14 Pages 2009
An examination of binding motifs associated with inter-particle interactions between facetted nano-crystals of acetylsalicylic acid and ascorbic acid through the application of molecular grid-based search methods Fulltext Access 14 Pages 2009
Reversal of Multidrug Resistance by Methoxypolyethylene Glycol-Block-Polycaprolactone Diblock Copolymers Through the Inhibition of P-Glycoprotein Function Fulltext Access 14 Pages 2009
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a “chemical knock-out equivalent” to assess the impact of efflux transporters on oral drug absorption in the rat Fulltext Access 14 Pages 2009
New chitosan derivatives for the preparation of rokitamycin loaded microspheres designed for ocular or nasal administration Fulltext Access 14 Pages 2009
Manipulating Hydrate Formation During High Shear Wet Granulation Using Polymeric Excipients Fulltext Access 14 Pages 2009
Evaluation of the Immuno-Stimulatory Potential of Stopper Extractables and Leachables by Using Dendritic Cells as Readout Fulltext Access 14 Pages 2009
The Effect of Starch Material, Encapsulated Protein and Production Conditions on the Protein Release from Starch Microspheres Fulltext Access 14 Pages 2009
Characterization of the Solubility and Solid-State Properties of Saccharin Salts of Fluoroquinolones Fulltext Access 14 Pages 2009
Biowaiver monographs for immediate release solid oral dosage forms: Quinidine sulfate Fulltext Access 14 Pages 2009
The Role of Force Control Agents in High-Dose Dry Powder Inhaler Formulations Fulltext Access 14 Pages 2009
Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Diclofenac Sodium and Diclofenac Potassium Fulltext Access 14 Pages 2009
Liquid Crystalline Systems of Phytantriol and Glyceryl Monooleate Containing a Hydrophilic Protein: Characterisation, Swelling and Release Kinetics Fulltext Access 14 Pages 2009
Synthesis, Characterization and In Vivo Activity of Salmon Calcitonin Coconjugated With Lipid and Polyethylene Glycol Fulltext Access 14 Pages 2009
Design of Lipid-Based Formulations for Oral Administration of Poorly Water-Soluble Drugs: Precipitation of Drug after Dispersion of Formulations in Aqueous Solution Fulltext Access 14 Pages 2009
Simultaneously manufactured nano-in-micro (SIMANIM) particles for dry-powder modified-release delivery of antibodies Fulltext Access 14 Pages 2009
Evaluation of polyanhydride microspheres for basal insulin delivery: Effect of copolymer composition and zinc salt on encapsulation, in vitro release, stability, in vivo absorption and bioactivity in diabetic rats Fulltext Access 14 Pages 2009
Rapid freeze-drying cycle optimization using computer programs developed based on heat and mass transfer models and facilitated by tunable diode laser absorption spectroscopy (TDLAS) Fulltext Access 14 Pages 2009
Investigation of the effects of altered receptor binding activity on the clearance of erythropoiesis-stimulating proteins: Nonerythropoietin receptor-mediated pathways may play a major role Fulltext Access 14 Pages 2009
Insulin Loaded PLGA Microspheres: Effect of Zinc Salts on Encapsulation, Release, and Stability Fulltext Access 14 Pages 2009
Characterization of MoistureâProtective Polymer Coatings Using Differential Scanning Calorimetry and Dynamic Vapor Sorption Fulltext Access 14 Pages 2009
Combined Effects of Wetting, Drying, and Microcrystalline Cellulose Type on the Mechanical Strength and Disintegration of Pellets Fulltext Access 14 Pages 2009
Influence of Chitosan Crosslinking on Bitterness of Mefloquine Hydrochloride Microparticles Using Central Composite Design Fulltext Access 14 Pages 2009