Lipid – An emerging platform for oral delivery of drugs with poor bioavailability Fulltext Access 15 Pages 2009
Lung-Specific Delivery of Paclitaxel by Chitosan-Modified PLGA Nanoparticles Via Transient Formation of Microaggregates Fulltext Access 15 Pages 2009
Characterization of chitin-metal silicates as binding superdisintegrants Fulltext Access 15 Pages 2009
Polyethylene sebacate: Genotoxicity, mutagenicity evaluation and application in periodontal drug delivery system Fulltext Access 15 Pages 2009
Intranasal drug targeting of hypocretin-1 (orexin-A) to the central nervous system Fulltext Access 15 Pages 2009
Comparison of Single Pot and Multiphase High Shear Wet Granulation Processes Related to Excipient Composition Fulltext Access 15 Pages 2009
Effect of formulation parameters and drug-polymer interactions on drug release from starch acetate matrix tablets Fulltext Access 15 Pages 2009
Kinetic modelling of NSAID action on COX-1: Focus on in vitro/in vivo aspects and drug combinations Fulltext Access 15 Pages 2009
Lipid membrane interactions of indacaterol and salmeterol: Do they influence their pharmacological properties? Fulltext Access 15 Pages 2009
A Near-Infrared Spectroscopic Investigation of Relative Density and Crushing Strength in Four-Component Compacts Fulltext Access 15 Pages 2009
Polymer nanocarriers for the delivery of small fragments of nucleic acids: Oligonucleotides and siRNA Fulltext Access 15 Pages 2009
Squalene: A natural triterpene for use in disease management and therapy Fulltext Access 15 Pages 2009
4-Phenoxybutoxy-substituted heterocycles – A structure–activity relationship study of blockers of the lymphocyte potassium channel Kv1.3 Fulltext Access 15 Pages 2009
Prediction of telomerase inhibitory activity for acridinic derivatives based on chemical structure Fulltext Access 15 Pages 2009
Distribution of Saquinavir, Methadone, and Buprenorphine in Maternal Brain, Placenta, and Fetus During Two Different Gestational Stages of Pregnancy in Mice Fulltext Access 15 Pages 2009
Prediction of solubility curves and melting properties of organic and pharmaceutical compounds Fulltext Access 15 Pages 2009
Levodopa delivery systems for the treatment of Parkinson's disease: An overview Fulltext Access 15 Pages 2009
Formulation of multifunctional oil-in-water nanosized emulsions for active and passive targeting of drugs to otherwise inaccessible internal organs of the human body Fulltext Access 15 Pages 2009
Development of Clinical Dosage Forms for a Poorly Water-Soluble Drug II: Formulation and Characterization of a Novel Solid Microemulsion Preconcentrate System for Oral Delivery of a Poorly Water-Soluble Drug Fulltext Access 15 Pages 2009
Determination of Mean Residence Time of Drug in Plasma and the Influence of the Initial Drug Elimination and Distribution on the Calculation of Pharmacokinetic Parameters Fulltext Access 15 Pages 2009
Differential Effect of Ethanol and Hydrogen Peroxide on Barrier Function and Prostaglandin E2 Release in Differentiated Cacoâ2 Cells: Selective Prevention by Growth Factors Fulltext Access 15 Pages 2009
Pharmacokinetics of Amitriptyline and One of Its Metabolites, Nortriptyline, in Rats: Little Contribution of Considerable Hepatic First-Pass Effect to Low Bioavailability of Amitriptyline Due to Great Intestinal First-Pass Effect Fulltext Access 15 Pages 2009
Sulphonylurea physicochemical-pharmacokinetic relationships in the pancreas and liver Fulltext Access 15 Pages 2009
Quality-By-Design (QbD): An Integrated Approach for Evaluation of Powder Blending Process Kinetics and Determination of Powder Blending End-point Fulltext Access 15 Pages 2009
Prediction of the possibility of the secondary peaks of iv bolus drug plasma concentration time curve by the model that directly takes into account the transit time through the organ Fulltext Access 15 Pages 2009
Effect of the pH grade of silicates on chemical stability of coground amorphous quinapril hydrochloride and its stabilization using pH-modifiers Fulltext Access 15 Pages 2009
Silicone Oil- and Agitation-Induced Aggregation of a Monoclonal Antibody in Aqueous Solution Fulltext Access 15 Pages 2009
The synthesis and biological evaluation of para-substituted phenolic N-alkyl carbamates as endocannabinoid hydrolyzing enzyme inhibitors Fulltext Access 15 Pages 2009
Studies on self-aggregation of anthracycline drugs by restrained molecular dynamics approach using nuclear magnetic resonance spectroscopy supported by absorption, fluorescence, diffusion ordered spectroscopy and mass spectrometry Fulltext Access 15 Pages 2009
Development of CoMFA and CoMSIA models of affinity and selectivity for indole ligands of cannabinoid CB1 and CB2 receptors Fulltext Access 15 Pages 2009
Design, synthesis and pharmacological screening of novel nitric oxide donors containing 1,5-diarylpyrazolin-3-one as nontoxic NSAIDs Fulltext Access 15 Pages 2009
Freeze-Dry Microscopy of Protein/Sugar Mixtures: Drying Behavior, Interpretation of Collapse Temperatures and a Comparison to Corresponding Glass Transition Data Fulltext Access 16 Pages 2009
Aryldiones incorporating a [1,4,5]oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden Fulltext Access 16 Pages 2009
Nonlinear Quantitative Structure-Property Relationship Modeling of Skin Permeation Coefficient Fulltext Access 16 Pages 2009
Pharmacokinetics of Liquiritigenin in Mice, Rats, Rabbits, and Dogs, and Animal Scale-Up Fulltext Access 16 Pages 2009
Synthesis, cannabinoid receptor affinity, molecular modeling studies and in vivo pharmacological evaluation of new substituted 1-aryl-5-(1H-pyrrol-1-yl)-1H-pyrazole-3-carboxamides. 2. Effect of the 3-carboxamide substituent on the affinity and selectivity Fulltext Access 16 Pages 2009
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate Fulltext Access 16 Pages 2009
Antiviral and cytotoxic activities of aminoarylazo compounds and aryltriazene derivatives Fulltext Access 16 Pages 2009
Mixing Properties of Lyophilized Protein Systems: A Spectroscopic and Calorimetric Study Fulltext Access 16 Pages 2009
Budesonide Nanoparticle Agglomerates as Dry Powder Aerosols With Rapid Dissolution Fulltext Access 16 Pages 2009
Remarkable enhancement in the DNA-binding ability of C2-fluoro substituted pyrrolo[2,1-c][1,4]benzodiazepines and their anticancer potential Fulltext Access 16 Pages 2009
Novel antagonists of serotonin-4 receptors: Synthesis and biological evaluation of pyrrolothienopyrazines Fulltext Access 16 Pages 2009
5-Vinyl-3-pyridinecarbonitrile inhibitors of PKCθ: Optimization of enzymatic and functional activity Fulltext Access 16 Pages 2009
Combining selectivity and affinity predictions using an integrated Support Vector Machine (SVM) approach: An alternative tool to discriminate between the human adenosine A2A and A3 receptor pyrazolo-triazolo-pyrimidine antagonists binding sites Fulltext Access 16 Pages 2009
Structure–activity studies on the nociceptin/orphanin FQ receptor antagonist 1-benzyl-N-{3-[spiroisobenzofuran-1(3H),4′-piperidin-1-yl]propyl} pyrrolidine-2-carboxamide Fulltext Access 16 Pages 2009
Antagonists of the human A2A receptor. Part 6: Further optimization of pyrimidine-4-carboxamides Fulltext Access 16 Pages 2009
Solubility Enhancement of a Poorly Water-Soluble Anti-Malarial Drug: Experimental Design and Use of a Modified Multifluid Nozzle Pilot Spray Drier Fulltext Access 16 Pages 2009
Comparative preclinical drug metabolism and pharmacokinetic evaluation of novel 4-aminoquinoline anti-malarials Fulltext Access 16 Pages 2009
The involvement of pro-inflammatory cytokines in nephrogenic systemic fibrosis – A mechanistic hypothesis based on preclinical results from a rat model treated with gadodiamide Fulltext Access 16 Pages 2009
Discovery of a series of acrylic acids and their derivatives as chemical leads for selective EP3 receptor antagonists Fulltext Access 16 Pages 2009
Comparison of benzil and trifluoromethyl ketone (TFK)-mediated carboxylesterase inhibition using classical and 3D-quantitative structure–activity relationship analysis Fulltext Access 16 Pages 2009
A thematic analysis for how patients, prescribers, experts, and patient advocates view the prescription choice process Fulltext Access 16 Pages 2009
A class of novel N-(3S-1,2,3,4-tetrahydroisoquinoline-3-carbonyl)-l-amino acid derivatives: their synthesis, anti-thrombotic activity evaluation, and 3D QSAR analysis Fulltext Access 16 Pages 2009
Nitrate tolerance as a model of vascular dysfunction: Roles for mitochondrial aldehyde dehydrogenase and mitochondrial oxidative stress Fulltext Access 16 Pages 2009
Design and synthesis of azolopyrimidoquinolines, pyrimidoquinazolines as anti-oxidant, anti-inflammatory and analgesic activities Fulltext Access 16 Pages 2009
Analogs of JHU75528, a PET ligand for imaging of cerebral cannabinoid receptors (CB1): Development of ligands with optimized lipophilicity and binding affinity Fulltext Access 16 Pages 2009
Synthesis and spectral characterization of a new class of N-(N-methylpiperazinoacetyl)-2,6-diarylpiperidin-4-ones: Antimicrobial, analgesic and antipyretic studies Fulltext Access 16 Pages 2009
In vitro and in vivo investigation of metabolic fate of rifampicin using an optimized sample preparation approach and modern tools of liquid chromatography–mass spectrometry Fulltext Access 16 Pages 2009
Synthesis, evaluation and 3D QSAR analysis of novel estradiol–RGD octapeptide conjugates with oral anti-osteoporosis activity Fulltext Access 16 Pages 2009
The porphyrin–fullerene nanoparticles to promote the ATP overproduction in myocardium: 25Mg2+-magnetic isotope effect Fulltext Access 16 Pages 2009
Postprandial Evolution in Composition and Characteristics of Human Duodenal Fluids in Different Nutritional States Fulltext Access 16 Pages 2009
Predictive QSAR modeling of HIV reverse transcriptase inhibitor TIBO derivatives Fulltext Access 16 Pages 2009
Multiscale modelling of drug-induced effects on cardiac electrophysiological activity Fulltext Access 16 Pages 2009
Effects of Oxygen-Containing Terpenes as Skin Permeation Enhancers on the Lipoidal Pathways of Human Epidermal Membrane Fulltext Access 16 Pages 2009
Development of Calcitonin Salmon Nasal Spray: Similarity of Peptide Formulated in Chlorobutanol Compared to Benzalkonium Chloride as Preservative Fulltext Access 16 Pages 2009
Biowaiver monographs for immediate release solid oral dosage forms: Rifampicin Fulltext Access 16 Pages 2009
Using empirical phase diagrams to understand the role of intramolecular dynamics in immunoglobulin G stability Fulltext Access 16 Pages 2009
Methionine, tryptophan, and histidine oxidation in a model protein, PTH: Mechanisms and stabilization Fulltext Access 16 Pages 2009