Kinetics and Mechanism of the Hydrolytic Degradation of Indinavir: Intramolecular Catalysis Fulltext Access 10 Pages 2008
Solid state stability of proteins III: Calorimetric (DSC) and spectroscopic (FTIR) characterization of thermal denaturation in freeze dried human growth hormone (hGH) Fulltext Access 10 Pages 2008
Effects of Inflammatory Response on In Vivo Transgene Expression by Plasmid DNA in Mice Fulltext Access 10 Pages 2008
Preparing calibration sets for use in pharmaceutical analysis by NIR spectroscopy Fulltext Access 10 Pages 2008
The potency of the adjuvant, CpG oligos, is enhanced by encapsulation in PLG microparticles Fulltext Access 10 Pages 2008
Biological rhythms: A neglected factor of variability in pharmacokinetic studies Fulltext Access 10 Pages 2008
Pharmacokinetic-Pharmacodynamic Modeling and Simulation for Bactericidal Effect in an In Vitro Dynamic Model Fulltext Access 10 Pages 2008
Quantifying Effects of Particulate Properties on Powder Flow Properties Using a Ring Shear Tester Fulltext Access 10 Pages 2008
Phase Transformation of Erythromycin A Dihydrate During Fluid Bed Drying Fulltext Access 10 Pages 2008
Characterisation of an inclusion complex between cladribine and 2-hydroxypropyl-β-cyclodextrin* Fulltext Access 10 Pages 2008
Changes in the Mucoadhesion of Powder Formulations after Drug Application Investigated with a Simplified Method Fulltext Access 10 Pages 2008
An Investigation into the Digestion of Chitosan (Noncrosslinked and Crosslinked) by Human Colonic Bacteria Fulltext Access 10 Pages 2008
Effect of dimethylâβâcyclodextrin concentrations on the pulmonary delivery of recombinant human growth hormone dry powder in rats Fulltext Access 10 Pages 2008
Molecular and Functional Expression of Multidrug Resistance-Associated Protein-1 in Primary Cultured Rat Alveolar Epithelial Cells Fulltext Access 10 Pages 2008
Preparation and Evaluation of Poly-Butylcyanoacrylate Nanoparticles for Oral Delivery of Thymopentin Fulltext Access 10 Pages 2008
Theoretical Dissolution Model of Poly-Disperse Drug Particles in Biorelevant Media Fulltext Access 10 Pages 2008
Improved Intestinal Membrane Permeability of Hexose-Quinoline Derivatives via the Hexose Transporter, SGLT1 Fulltext Access 10 Pages 2008
Evaluation of the Pharmacokinetics of All-Trans-Retinoic Acid (ATRA) in Wistar Rats After Intravenous Administration of ATRA Loaded into Tributyrin Submicron Emulsion and its Cellular Activity on Caco-2 and HepG2 Cell Lines Fulltext Access 10 Pages 2008
The Effect of Cyclodextrins on Chemical and Physical Stability of Glucagon and Characterization of Glucagon/γ-CD Inclusion Complexes Fulltext Access 10 Pages 2008
Chemical Degradation of Peptides and Proteins in PLGA: A Review of Reactions and Mechanisms Fulltext Access 10 Pages 2008
Validation of a Rapid Equilibrium Dialysis Approach for the Measurement of Plasma Protein Binding Fulltext Access 10 Pages 2008
Miscibility and interactions between 17β-estradiol and Eudragit® RS in solid dispersion Fulltext Access 10 Pages 2008
Use/misuse of over-the-counter medications and associated adverse drug events among HIV-infected patients Fulltext Access 10 Pages 2008
“I just don't know what I'm supposed to know”: Evaluating self-assessment skills of international pharmacy graduates in Canada Fulltext Access 10 Pages 2008
Phytochemical composition and in vitro pharmacological activity of two rose hip (Rosa canina L.) preparations Fulltext Access 10 Pages 2008
Lipolytic effect of a polyphenolic citrus dry extract of red orange, grapefruit, orange (SINETROL) in human body fat adipocytes. Mechanism of action by inhibition of cAMP-phosphodiesterase (PDE) Fulltext Access 10 Pages 2008
Regulative effects of essential oil from Atractylodes lancea on delayed gastric emptying in stress-induced rats Fulltext Access 10 Pages 2008
Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice Fulltext Access 10 Pages 2008
Effect of seabuckthorn leaf extracts on circulating energy fuels, lipid peroxidation and antioxidant parameters in rats during exposure to cold, hypoxia and restraint (C–H–R) stress and post stress recovery Fulltext Access 10 Pages 2008
Antinociceptive activity of petroleum ether fraction from the MeOH extracts of Paederia scandens in mice Fulltext Access 10 Pages 2008
The ovariectomized, mature rat model of postmenopausal osteoporosis: An assessment of the bone sparing effects of curcumin Fulltext Access 10 Pages 2008
Temperature scanning FTIR analysis of interactions between sugar and polymer additive in amorphous sugar–polymer mixtures Fulltext Access 10 Pages 2008
Estimation of Cholesterol Solubilization by a Mixed Micelle Binding Model in Aqueous Tauroursodeoxycholate:Lecithin:Cholesterol Solutions Fulltext Access 10 Pages 2008
Fluticasone and budesonide nanosuspensions for pulmonary delivery: Preparation, characterization, and pharmacokinetic studies Fulltext Access 10 Pages 2008
Ethyl-paraben and nicotinamide mixtures: Apparent solubility, thermal behavior and X-ray structure of the 1:1 co-crystal Fulltext Access 10 Pages 2008
The Effect of a Point Mutation on the Stability of IgG4 as Monitored by Analytical Ultracentrifugation Fulltext Access 10 Pages 2008
Real-Time Assessment of Granule and Tablet Properties Using In-line Data From a High-shear Granulation Process Fulltext Access 10 Pages 2008
Isolation, Identification, and Synthesis of Two Oxidative Degradation Products of Olanzapine (LY170053) in Solid Oral Formulations Fulltext Access 10 Pages 2008
Renal excretion of emtricitabine II. Effect of trimethoprim on emtricitabine excretion: In vitro and in vivo studies Fulltext Access 10 Pages 2008
Renal excretion of emtricitabine I: Effects of organic anion, organic cation, and nucleoside transport inhibitors on emtricitabine excretion Fulltext Access 10 Pages 2008
Pharmacokinetics of DSâ96, an Alkylpolyamine Lipopolysaccharide Sequestrant, in Rodents Fulltext Access 10 Pages 2008
Analysis of low content drug tablets by transmission near infrared spectroscopy: Selection of calibration ranges according to multivariate detection and quantitation limits of PLS models Fulltext Access 10 Pages 2008
Investigating improving powder deagglomeration via dry powder inhalers at a low inspiratory flow rate by employing addâon spacers Fulltext Access 10 Pages 2008
Specific binding capacity of β-cyclodextrin with cis and trans enalapril: Physicochemical characterization and structural studies by molecular modeling Fulltext Access 10 Pages 2008
Diarylmethyloxime and hydrazone derivatives with 5-indolyl moieties as potent inhibitors of tubulin polymerization Fulltext Access 10 Pages 2008
Unified QSAR approach to antimicrobials. Part 3: First multi-tasking QSAR model for Input-Coded prediction, structural back-projection, and complex networks clustering of antiprotozoal compounds Fulltext Access 10 Pages 2008
N-Propynyl analogs of β-phenylethylidenehydrazines: Synthesis and evaluation of effects on glycine, GABA, and monoamine oxidase Fulltext Access 10 Pages 2008
Synthesis, structural studies and biological properties of new TBA analogues containing an acyclic nucleotide Fulltext Access 10 Pages 2008
Identification of SVM-based classification model, synthesis and evaluation of prenylated flavonoids as vasorelaxant agents Fulltext Access 10 Pages 2008
Chemoenzymatic syntheses of prenylated aromatic small molecules using Streptomyces prenyltransferases with relaxed substrate specificities Fulltext Access 10 Pages 2008
Synthesis, in vitro, and in vivo biological evaluation and molecular docking simulations of chiral alcohol and ether derivatives of the 1,5-diarylpyrrole scaffold as novel anti-inflammatory and analgesic agents Fulltext Access 10 Pages 2008
Novel iron complexes bearing N6-substituted adenosine derivatives: Synthesis, magnetic, 57Fe Mössbauer, DFT, and in vitro cytotoxicity studies Fulltext Access 10 Pages 2008
Derivatives of 1,4-bis(3-hydroxycarbonyl-4-hydroxyl)styrylbenzene as PTP1B inhibitors with hypoglycemic activity Fulltext Access 10 Pages 2008
Tetrahydropyridine-4-carboxamides as novel, potent transient receptor potential vanilloid 1 (TRPV1) antagonists Fulltext Access 10 Pages 2008
Synthesis and biological evaluation of indolyl bisphosphonates as anti-bone resorptive and anti-leishmanial agents Fulltext Access 10 Pages 2008
‘Hybrid’ benzofuran–benzopyran congeners as rigid analogs of hallucinogenic phenethylamines Fulltext Access 10 Pages 2008
CYP19 (aromatase): Exploring the scaffold flexibility for novel selective inhibitors Fulltext Access 10 Pages 2008
Synthesis of 3-phenylnaphthalenic derivatives as new selective MT2 melatoninergic ligands Fulltext Access 10 Pages 2008
Binding effect and design of a competitive inhibitory peptide for HMG-CoA reductase through modeling of an active peptide backbone Fulltext Access 10 Pages 2008
Structure–activity relationships of novel HIV-1 protease inhibitors containing the 3-amino-2-chlorobenzoyl-allophenylnorstatine structure Fulltext Access 10 Pages 2008
Synthesis and heme-binding correlation with antimalarial activity of 3,6-bis-(ω-N,N-diethylaminoamyloxy)-4,5-difluoroxanthone Fulltext Access 10 Pages 2008
Targeting the inverted CCAAT Box-2 of the topoisomerase IIα gene: DNA sequence selective recognition by a polyamide–intercalator as a staggered dimer Fulltext Access 10 Pages 2008
Design of azidoproline containing gluten peptides to suppress CD4+ T-cell responses associated with Celiac disease Fulltext Access 10 Pages 2008
Aryl azoles with neuroprotective activity—Parallel synthesis and attempts at target identification Fulltext Access 10 Pages 2008
Potent and selective small molecule NS3 serine protease inhibitors of Hepatitis C virus with dichlorocyclopropylproline as P2 residue Fulltext Access 10 Pages 2008
The synthesis of bivalent 2β-carbomethoxy-3β-(3,4-dichlorophenyl)-8-heterobicyclo[3.2.1]octanes as probes for proximal binding sites on the dopamine and serotonin transporters Fulltext Access 10 Pages 2008
Design, Synthesis and Evaluation of Antiinflammatory, Analgesic and Ulcerogenicity studies of Novel S-Substituted phenacyl-1,3,4-oxadiazole-2-thiol and Schiff bases of Diclofenac acid as Nonulcerogenic Derivatives Fulltext Access 10 Pages 2008
Novel anti-inflammatory agents based on pyridazinone scaffold; design, synthesis and in vivo activity Fulltext Access 10 Pages 2008
Alkyl deoxy-arabino-hexopyranosides: Synthesis, surface properties, and biological activities Fulltext Access 10 Pages 2008
A class of novel nitronyl nitroxide labeling basic and acidic amino acids: Synthesis, application for preparing ESR optionally labeling peptides, and bioactivity investigations Fulltext Access 10 Pages 2008
Prediction of intestinal absorption and metabolism of pharmacologically active flavones and flavanones Fulltext Access 10 Pages 2008
The structure-based design, synthesis and biological evaluation of DNA-binding bisintercalating bisanthrapyrazole anticancer compounds Fulltext Access 10 Pages 2008
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors Fulltext Access 10 Pages 2008
Platinum(II) complexes with steroidal esters of l-methionine and l-histidine: Synthesis, characterization and cytotoxic activity Fulltext Access 10 Pages 2008
Methoxylation of 3′,4′-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells Fulltext Access 10 Pages 2008
In vitro permeability and metabolic stability of bile pigments and the effects of hydrophilic and lipophilic modification of biliverdin Fulltext Access 10 Pages 2008
Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor Fulltext Access 10 Pages 2008
Identification of 4-[1-[3-chloro-4-[N’-(5-fluoro-2-methylphenyl)ureido]phenylacetyl]-(4S)-fluoro-(2S)-pyrrolidinylmethoxy]benzoic acid as a potent, orally active VLA-4 antagonist Fulltext Access 10 Pages 2008
Thermodynamics and fluorescence studies of the interactions of cyclooctapeptides with Hg2+, Pb2+, and Cd2+ Fulltext Access 10 Pages 2008
Prediction of the aqueous solvation free energy of organic compounds by using autocorrelation of molecular electrostatic potential surface properties combined with response surface analysis Fulltext Access 10 Pages 2008
Design and synthesis of a siderophore conjugate as a potent PSMA inhibitor and potential diagnostic agent for prostate cancer Fulltext Access 10 Pages 2008
Synthesis of 5′-functionalized nucleosides: S-Adenosylhomocysteine analogues with the carbon-5′ and sulfur atoms replaced by a vinyl or halovinyl unit Fulltext Access 10 Pages 2008
Design, synthesis, and biological evaluation of thiophene analogues of chalcones Fulltext Access 10 Pages 2008
Novel insights into GPCR—Peptide interactions: Mutations in extracellular loop 1, ligand backbone methylations and molecular modeling of neurotensin receptor 1 Fulltext Access 10 Pages 2008
Structure–activity relationships of 1,4-dihydropyridines that act as enhancers of the vanilloid receptor 1 (TRPV1) Fulltext Access 10 Pages 2008
Synthesis and antitumoral evaluation of indole alkaloid analogues containing an hexahydropyrrolo[1′,2′,3′:1,9a,9]imidazo[1,2-a]indole skeleton Fulltext Access 10 Pages 2008
4-Anilino-7-alkenylquinoline-3-carbonitriles as potent MEK1 kinase inhibitors Fulltext Access 10 Pages 2008
Antitumor studies. Part 5: Synthesis, antitumor activity, and molecular docking study of 5-(monosubstituted amino)-2-deoxo-2-phenyl-5-deazaflavins Fulltext Access 10 Pages 2008
2,2′-Bipyridinebutyldithiocarbamatoplatinum(II) and palladium(II) complexes: Synthesis, characterization, cytotoxicity, and rich DNA-binding studies Fulltext Access 10 Pages 2008
Influence of 6- or 8-substitution on the antiviral activity of 3-arylalkylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (CMV) and varicella-zoster virus (VZV): Part II Fulltext Access 10 Pages 2008
Novel potent and selective Ca2+ release-activated Ca2+ (CRAC) channel inhibitors. Part 3: Synthesis and CRAC channel inhibitory activity of 4′-[(trifluoromethyl)pyrazol-1-yl]carboxanilides Fulltext Access 10 Pages 2008