PEG-uricase in the management of treatment-resistant gout and hyperuricemia Fulltext Access 10 Pages 2008
Design and in vitro/in vivo evaluation of novel nicorandil extended release matrix tablets based on hydrophilic interpolymer complexes and a hydrophobic waxy polymer Fulltext Access 10 Pages 2008
Modulation of drug release kinetics of shellac-based matrix tablets by in-situ polymerization through annealing process Fulltext Access 10 Pages 2008
Quercetin in w/o microemulsion: In vitro and in vivo skin penetration and efficacy against UVB-induced skin damages evaluated in vivo Fulltext Access 10 Pages 2008
Preparation and, in vitro, preclinical and clinical studies of aceclofenac spherical agglomerates Fulltext Access 10 Pages 2008
Influence of plasticizers on the stability and release of a prodrug of Δ9-tetrahydrocannabinol incorporated in poly (ethylene oxide) matrices Fulltext Access 10 Pages 2008
GMP production of pDERMATT for vaccination against melanoma in a phase I clinical trial Fulltext Access 10 Pages 2008
Nebulization of nanoparticulate amorphous or crystalline tacrolimus – Single-dose pharmacokinetics study in mice Fulltext Access 10 Pages 2008
Renal uptake and metabolism of radiopharmaceuticals derived from peptides and proteins Fulltext Access 10 Pages 2008
Methodological and cellular aspects that govern the internalization mechanisms of arginine-rich cell-penetrating peptides Fulltext Access 10 Pages 2008
Role of dichloroacetate in the treatment of genetic mitochondrial diseases Fulltext Access 10 Pages 2008
Lipid excipients and delivery systems for pharmaceutical development: A regulatory perspective Fulltext Access 10 Pages 2008
Challenges and opportunities in the encapsulation of liquid and semi-solid formulations into capsules for oral administration Fulltext Access 10 Pages 2008
Enhancing drug absorption using lipids: A case study presenting the development and pharmacological evaluation of a novel lipid-based oral amphotericin B formulation for the treatment of systemic fungal infections Fulltext Access 10 Pages 2008
New HPMA copolymer-based drug carriers with covalently bound hydrophobic substituents for solid tumour targeting Fulltext Access 10 Pages 2008
New insights on poly(vinyl acetate)-based coated floating tablets: Characterisation of hydration and CO2 generation by benchtop MRI and its relation to drug release and floating strength Fulltext Access 10 Pages 2008
New spray congealing atomizer for the microencapsulation of highly concentrated solid and liquid substances Fulltext Access 10 Pages 2008
The manufacture and characterisation of hot-melt extruded enteric tablets Fulltext Access 10 Pages 2008
Magnetite/poly(alkylcyanoacrylate) (core/shell) nanoparticles as 5-Fluorouracil delivery systems for active targeting Fulltext Access 10 Pages 2008
Formation of shellac succinate having improved enteric film properties through dry media reaction Fulltext Access 10 Pages 2008
Pharmaceutical excipients inhibit cytochrome P450 activity in cell free systems and after systemic administration Fulltext Access 10 Pages 2008
Formulation and in vitro evaluation of cysteamine hydrochloride viscous solutions for the treatment of corneal cystinosis Fulltext Access 10 Pages 2008
Reversible protein precipitation to ensure stability during encapsulation within PLGA microspheres Fulltext Access 10 Pages 2008
Targeted delivery of tacrine into the brain with polysorbate 80-coated poly(n-butylcyanoacrylate) nanoparticles Fulltext Access 10 Pages 2008
Reversible pegylation of insulin facilitates its prolonged action in vivo Fulltext Access 10 Pages 2008
Designing biorelevant dissolution tests for lipid formulations: Case example – Lipid suspension of RZ-50 Fulltext Access 10 Pages 2008
The effects of cryoprotectants on the freeze-drying of ibuprofen-loaded solid lipid microparticles (SLM) Fulltext Access 10 Pages 2008
Nanoimprint lithography based fabrication of shape-specific, enzymatically-triggered smart nanoparticles Fulltext Access 10 Pages 2008
Effect of calcium ions on the gelling and drug release characteristics of xanthan matrix tablets Fulltext Access 10 Pages 2008
Using biorelevant dissolution to obtain IVIVC of solid dosage forms containing a poorly-soluble model compound Fulltext Access 10 Pages 2008
Controlled nerve growth factor release from multi-ply alginate/chitosan-based nerve conduits Fulltext Access 10 Pages 2008
Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state Fulltext Access 10 Pages 2008
Preparation and characterisation of controlled release co-spray dried drug–polymer microparticles for inhalation 1: Influence of polymer concentration on physical and in vitro characteristics Fulltext Access 10 Pages 2008
Preparation and evaluation of microparticles from thiolated polymers via air jet milling Fulltext Access 10 Pages 2008
Effective insulin delivery using starch nanoparticles as a potential trans-nasal mucoadhesive carrier Fulltext Access 10 Pages 2008
Physicochemical stability of phospholipid-dispersed suspensions of crystalline itraconazole Fulltext Access 10 Pages 2008
Macromolecule release and smoothness of semi-interpenetrating PVP–pHEMA networks for comfortable soft contact lenses Fulltext Access 10 Pages 2008
Thermodynamic behavior of glassy state of structurally related compounds Fulltext Access 10 Pages 2008
3D-QSAR studies of triazafluorenone inhibitors of metabotropic glutamate receptor subtype 1 Fulltext Access 10 Pages 2008
3D-QSAR and docking studies of aminopyridine carboxamide inhibitors of c-Jun N-terminal kinase-1 Fulltext Access 10 Pages 2008
Synthesis and evaluation of 4-amino-3,4-dihydro-2H-naphthalen-1-one derivatives as mast cell stabilising and anti-inflammatory compounds Fulltext Access 10 Pages 2008
Bisphosphonate sequestering agents. Synthesis and preliminary evaluation for in vitro and in vivo uranium(VI) chelation Fulltext Access 10 Pages 2008
Identification of “toxicophoric” features for predicting drug-induced QT interval prolongation Fulltext Access 10 Pages 2008
Schiff base transition metal complexes as novel inhibitors of xanthine oxidase Fulltext Access 10 Pages 2008
Synthesis of N-aryl-5-amino-4-cyanopyrazole derivatives as potent xanthine oxidase inhibitors Fulltext Access 10 Pages 2008
Synthesis and structure–antibacterial activity of triazolyl oxazolidinones containing long chain acyl moiety Fulltext Access 10 Pages 2008
Synthesis, structure elucidation and identification of antitumoural properties of novel fused 1,2,4-triazine aryl derivatives Fulltext Access 10 Pages 2008
QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of β-ketoacyl-acyl carrier protein synthase III Fulltext Access 10 Pages 2008
Synthesis, binding properties and receptor docking of 4-halo-6-[2-(4-arylpiperazin-1-yl)ethyl]-1H-benzimidazoles, mixed ligands of D2 and 5-HT1A receptors Fulltext Access 10 Pages 2008
Synthesis, properties, and perspectives of gem-diphosphono substituted-thiazoles Fulltext Access 10 Pages 2008
Synthesis, anti-bacterial, anti-asthmatic and anti-diabetic activities of novel N-substituted-2-(4-phenylethynyl-phenyl)-1H-benzimidazoles and N-substituted 2[4-(4,4-dimethyl-thiochroman-6-yl-ethynyl)-phenyl)-1H-benzimidazoles Fulltext Access 10 Pages 2008
4-Nitroacetophenone-derived thiosemicarbazones and their copper(II) complexes with significant in vitro anti-trypanosomal activity Fulltext Access 10 Pages 2008
Quantitative structure–activity relationship studies of a series of non-benzodiazepine structural ligands binding to benzodiazepine receptor Fulltext Access 10 Pages 2008
Inhibition of PDGFR tyrosine kinase activity by a series of novel N-(3-(4-(pyridin-3-yl)-1H-imidazol-2-ylamino)phenyl)amides – A SAR study on the bioisosterism of pyrimidine and imidazole Fulltext Access 10 Pages 2008
Synthesis and molecular modelling of unsaturated exomethylene pyranonucleoside analogues with antitumor and antiviral activities Fulltext Access 10 Pages 2008
Design, synthesis and characterization of some bioactive conjugates of curcumin with glycine, glutamic acid, valine and demethylenated piperic acid and study of their antimicrobial and antiproliferative properties Fulltext Access 10 Pages 2008
Synthesis of new 3-pyridinecarboxylates of potential vasodilation properties Fulltext Access 10 Pages 2008
Carbodithioic acid esters of fluoxetine, a novel class of dual-function spermicides Fulltext Access 10 Pages 2008
Synthesis and structure guided evaluation of estrogen agonist and antagonist activities of some new tetrazolyl indole derivatives Fulltext Access 10 Pages 2008
Design, synthesis and preliminary evaluation of novel pyrrolidine derivatives as matrix metalloproteinase inhibitors Fulltext Access 10 Pages 2008
Insulin-like growth factor I releasing silk fibroin scaffolds induce chondrogenic differentiation of human mesenchymal stem cells Fulltext Access 10 Pages 2008
Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin–liposome nanocomplexes Fulltext Access 10 Pages 2008
Local and systemic delivery of VEGF siRNA using polyelectrolyte complex micelles for effective treatment of cancer Fulltext Access 10 Pages 2008
Characterization of the transgene expression generated by branched and linear polyethylenimine-plasmid DNA nanoparticles in vitro and after intraperitoneal injection in vivo Fulltext Access 10 Pages 2008
Increase of therapeutic effects by treating melanoma with targeted combinations of c-myc antisense and doxorubicin Fulltext Access 10 Pages 2008
A fast and sensitive method for measuring the integrity of siRNA-carrier complexes in full human serum Fulltext Access 10 Pages 2008
Effects of extracellular calcium on cell membrane resealing in sonoporation Fulltext Access 10 Pages 2008
A novel IRQ ligand-modified nano-carrier targeted to a unique pathway of caveolar endocytic pathway Fulltext Access 10 Pages 2008
Gene delivery using chitosan, trimethyl chitosan or polyethylenglycol-graft-trimethyl chitosan block copolymers: Establishment of structure–activity relationships in vitro Fulltext Access 10 Pages 2008
Efficient targeting to alveolar macrophages by intratracheal administration of mannosylated liposomes in rats Fulltext Access 10 Pages 2008
Biorelevant dissolution testing of colon-specific delivery systems activated by colonic microflora Fulltext Access 10 Pages 2008
Bio-nanocapsule conjugated with liposomes for in vivo pinpoint delivery of various materials Fulltext Access 10 Pages 2008
Mechanistic model for drug release during the lag phase from pellets coated with a semi-permeable membrane Fulltext Access 10 Pages 2008
DNA binding and biological studies of some novel water-soluble polymer-copper(II)-phenanthroline complexes Fulltext Access 10 Pages 2008
Synergistic antitumoral effect of vinblastine and HSV-Tk/GCV gene therapy mediated by albumin-associated cationic liposomes Fulltext Access 10 Pages 2008
Long-term in vitro study of paclitaxel-eluting bioresorbable core/shell fiber structures Fulltext Access 10 Pages 2008
Efficacy of pulmonary insulin delivery in diabetic rats: Use of a model-based approach in the evaluation of insulin powder formulations Fulltext Access 10 Pages 2008
Antitumoral activity of PEG–gemcitabine prodrugs targeted by folic acid Fulltext Access 10 Pages 2008
Preparing polymer-based sustained-release systems without exposing proteins to water–oil or water–air interfaces and cross-linking reagents Fulltext Access 10 Pages 2008
Drug release and swelling kinetics of directly compressed glipizide sustained-release matrices: Establishment of level A IVIVC Fulltext Access 10 Pages 2008
Rationalizing the selection of oral lipid based drug delivery systems by an in vitro dynamic lipolysis model for improved oral bioavailability of poorly water soluble drugs Fulltext Access 10 Pages 2008
New strategies for nucleic acid delivery to conquer cellular and nuclear membranes Fulltext Access 10 Pages 2008
Polyhydroxyethylaspartamide-spermine copolymers: Efficient vectors for gene delivery Fulltext Access 10 Pages 2008
Classification of estrogen receptor-β ligands on the basis of their binding affinities using support vector machine and linear discriminant analysis Fulltext Access 10 Pages 2008
Comparison of the cytotoxic activities of naturally occurring hydroxyanthraquinones and hydroxynaphthoquinones Fulltext Access 10 Pages 2008