ω-(2-Naphthyloxy) amino alkanes as a novel class of anti-hyperglycemic and lipid lowering agents Fulltext Access 10 Pages 2008
Synthesis of new N-phenylpyrazole derivatives with potent antimicrobial activity Fulltext Access 10 Pages 2008
Investigating biological activity spectrum for novel quinoline analogues 2: Hydroxyquinolinecarboxamides with photosynthesis-inhibiting activity Fulltext Access 10 Pages 2008
Potential antitumoral properties of a new copper complex with santonic acid Fulltext Access 10 Pages 2008
Synthesis and antioxidant properties of novel N-methyl-1,3,4-thiadiazol-2-amine and 4-methyl-2H-1,2,4-triazole-3(4H)-thione derivatives of benzimidazole class Fulltext Access 10 Pages 2008
Synthesis, SAR and in vitro evaluation of new cyclic Arg-Gly-Asp pseudopentapeptides containing a s-cis peptide bond as integrin αvβ3 and αvβ5 ligands Fulltext Access 10 Pages 2008
Design, synthesis and pharmacological evaluation of hybrid molecules out of quinazolinimines and lipoic acid lead to highly potent and selective butyrylcholinesterase inhibitors with antioxidant properties Fulltext Access 10 Pages 2008
Formation of fluorine-18 labeled diaryl ureas—labeled VEGFR-2/PDGFR dual inhibitors as molecular imaging agents for angiogenesis Fulltext Access 10 Pages 2008
Selective COX-2 inhibitors. Part 2: Synthesis and biological evaluation of 4-benzylideneamino- and 4-phenyliminomethyl-benzenesulfonamides Fulltext Access 10 Pages 2008
Amphiphilic chitosan nanosphere: Studies on formation, toxicity, and guest molecule incorporation Fulltext Access 10 Pages 2008
Designed modification of partial agonist of ORL1 nociceptin receptor for conversion into highly potent antagonist Fulltext Access 10 Pages 2008
Novel AMPA and kainate receptor antagonists containing the pyrazolo[1,5-c]quinazoline ring system: Synthesis and structure-activity relationships Fulltext Access 10 Pages 2008
Structure–activity relationships in the inhibition of monoamine oxidase B by 1-methyl-3-phenylpyrroles Fulltext Access 10 Pages 2008
Activation and inhibition of DNA methyltransferases by S-adenosyl-l-homocysteine analogues Fulltext Access 10 Pages 2008
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle Fulltext Access 10 Pages 2008
Design, synthesis, and structure–affinity relationship studies in NK1 receptor ligands based on azole-fused quinolinecarboxamide moieties Fulltext Access 10 Pages 2008
Conjugates of gonadotropin releasing hormone (GnRH) with carminic acid: Synthesis, generation of reactive oxygen species (ROS) and biological evaluation Fulltext Access 10 Pages 2008
Antiprion activity of functionalized 9-aminoacridines related to quinacrine Fulltext Access 10 Pages 2008
Synthesis and structure–activity relationship studies in peripheral benzodiazepine receptor ligands related to alpidem Fulltext Access 10 Pages 2008
Synthetic derivatives of the α- and β-amyrin triterpenes and their antinociceptive properties Fulltext Access 10 Pages 2008
Oligo(tyrosine sulfate)s as heparin pentasaccharide mimic: Evaluation by surface noncovalent affinity mass spectrometry Fulltext Access 10 Pages 2008
Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors Fulltext Access 10 Pages 2008
Synthesis and antiproliferative evaluation of certain indeno[1,2-c]quinoline derivatives Fulltext Access 10 Pages 2008
No carrier added synthesis of O-(2′-[18F]fluoroethyl)-l-tyrosine via a novel type of chiral enantiomerically pure precursor, NiII complex of a (S)-tyrosine Schiff base Fulltext Access 10 Pages 2008
Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands Fulltext Access 10 Pages 2008
Characterization of carbosilane dendrimers as effective carriers of siRNA to HIV-infected lymphocytes Fulltext Access 10 Pages 2008
Oligoethylenimine-grafted polypropylenimine dendrimers as degradable and biocompatible synthetic vectors for gene delivery Fulltext Access 10 Pages 2008
Quantitative structural–activity relationship (QSAR) study for fungicidal activities of thiazoline derivatives against rice blast Fulltext Access 10 Pages 2008
Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments Fulltext Access 10 Pages 2008
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part II: Acyclic replacements for the (3S)-3-benzylpiperidine in a series of potent CCR3 antagonists Fulltext Access 10 Pages 2008
From rigid cyclic templates to conformationally stabilized acyclic scaffolds. Part I: The discovery of CCR3 antagonist development candidate BMS-639623 with picomolar inhibition potency against eosinophil chemotaxis Fulltext Access 10 Pages 2008
Novel thiosemicarbazone derivatives as potential antitumor agents: Synthesis, physicochemical and structural properties, DNA interactions and antiproliferative activity Fulltext Access 10 Pages 2008
Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin β4, ROS, and p53 levels in vascular endothelial cells Fulltext Access 10 Pages 2008
Design and synthesis of biologically active analogues of vitamin K2: Evaluation of their biological activities with cultured human cell lines Fulltext Access 10 Pages 2008
Molecular modeling and dynamics simulations of PNP from Streptococcus agalactiae Fulltext Access 10 Pages 2008
1,5-Disubstituted 1,2,3-triazoles as cis-restricted analogues of combretastatin A-4: Synthesis, molecular modeling and evaluation as cytotoxic agents and inhibitors of tubulin Fulltext Access 10 Pages 2008
Targeting of polyamidoamine–DNA nanoparticles using the Staudinger ligation: Attachment of an RGD motif either before or after complexation Fulltext Access 10 Pages 2008
In vitro and in vivo anti-tumoral activities of imidazo[1,2-a]quinoxaline, imidazo[1,5-a]quinoxaline, and pyrazolo[1,5-a]quinoxaline derivatives Fulltext Access 10 Pages 2008
Mono- and dialkyl isoprenoid bisphosphonates as geranylgeranyl diphosphate synthase inhibitors Fulltext Access 10 Pages 2008
Synthesis and evaluation of cationic phthalocyanine derivatives as potential inhibitors of telomerase Fulltext Access 10 Pages 2008
In vitro spermicidal activity of peptides from amphibian skin: Dermaseptin S4 and derivatives Fulltext Access 10 Pages 2008
Discovery and structure–activity relationship of N-phenyl-1H-pyrazolo[3,4-b]quinolin-4-amines as a new series of potent apoptosis inducers Fulltext Access 10 Pages 2008
Functionalized chalcones as selective inhibitors of P-glycoprotein and breast cancer resistance protein Fulltext Access 10 Pages 2008
Fluorescence-based detection of short DNA sequences under non-denaturing conditions Fulltext Access 10 Pages 2008
Synthesis and pharmacological activity of chalcones derived from 2,4,6-trimethoxyacetophenone in RAW 264.7 cells stimulated by LPS: Quantitative structure–activity relationships Fulltext Access 10 Pages 2008
Trypsin immobilization on three monolithic disks for on-line protein digestion Fulltext Access 10 Pages 2008
1,3-Dialkyl-8-(hetero)aryl-9-OH-9-deazaxanthines as potent A2B adenosine receptor antagonists: Design, synthesis, structure–affinity and structure–selectivity relationships Fulltext Access 10 Pages 2008
New retinoid chemotypes: 9-cis-Retinoic acid analogs with hydrophobic rings derived from terpenes as selective RAR agonists Fulltext Access 10 Pages 2008
Quantitative Proteome–Property Relationships (QPPRs). Part 1: Finding biomarkers of organic drugs with mean Markov connectivity indices of spiral networks of blood mass spectra Fulltext Access 10 Pages 2008
Synthesis and biological activities of novel nonpeptide angiotensin II receptor antagonists based on benzimidazole derivatives bearing a heterocyclic ring Fulltext Access 10 Pages 2008
Studies on quinones. Part 44: Novel angucyclinone N-heterocyclic analogues endowed with antitumoral activity Fulltext Access 10 Pages 2008
Development and validation of a high-performance liquid chromatography–electrospray mass spectrometry method for the simultaneous determination of 23 eicosanoids Fulltext Access 10 Pages 2008
Beyond pass/fail: A procedure for evaluating the effect of carryover in bioanalytical LC/MS/MS methods Fulltext Access 10 Pages 2008
LC-UV/MS characterization and DOE optimization of the iodinated peptide obestatin Fulltext Access 10 Pages 2008
Development of a validated RP-LC/ESI-MS–MS method for separation, identification and determination of related substances of tamsulosin in bulk drugs and formulations Fulltext Access 10 Pages 2008
Identification and quantification of 32 bioactive compounds in Lonicera species by high performance liquid chromatography coupled with time-of-flight mass spectrometry Fulltext Access 10 Pages 2008
A rapid method for simultaneous determination of 15 flavonoids in Epimedium using pressurized liquid extraction and ultra-performance liquid chromatography Fulltext Access 10 Pages 2008
Cellulose tris(3,5-dichlorophenylcarbamate) immobilised on silica: A novel chiral stationary phase for resolution of enantiomers Fulltext Access 10 Pages 2008
Efficient one-cycle affinity selection of binding proteins or peptides specific for a small-molecule using a T7 phage display pool Fulltext Access 10 Pages 2008
Sensitive LC–MS/MS methods for the quantification of RGH-188 and its active metabolites, desmethyl- and didesmethyl-RGH-188 in human plasma and urine Fulltext Access 10 Pages 2008
Determination of linezolid and its achiral impurities using sweeping preconcentration by micellar capillary electrophoresis Fulltext Access 10 Pages 2008
New immunosensor for Lactoferrin determination in human milk and several pharmaceutical dairy milk products recommended for the unweaned diet Fulltext Access 10 Pages 2008
Determination of ephedrine alkaloids in Ephedra natural products using HPLC on a pentafluorophenylpropyl stationary phase Fulltext Access 10 Pages 2008
Automated tryptic digestion procedure for HPLC/MS/MS peptide mapping of immunoglobulin gamma antibodies in pharmaceutics Fulltext Access 10 Pages 2008
The use of net analyte signal orthogonalization in the separation of multi-component diffraction patterns obtained from X-ray powder diffraction of intact compacts Fulltext Access 10 Pages 2008
Rapid simultaneous quantification of five active constituents in rat plasma by high-performance liquid chromatography/tandem mass spectrometry after oral administration of Da-Cheng-Qi decoction Fulltext Access 10 Pages 2008
Characterization of phenolic compounds in the Chinese herbal drug Artemisia annua by liquid chromatography coupled to electrospray ionization mass spectrometry Fulltext Access 10 Pages 2008
A sensitive human bone assay for quantitation of tigecycline using LC/MS/MS Fulltext Access 10 Pages 2008
A rapid method for chemical fingerprint analysis of Hoodia species, related genera, and dietary supplements using UPLC–UV–MS Fulltext Access 10 Pages 2008
Polypill for the treatment of cardiovascular diseases: Part 2. LC–MS/TOF characterization of interaction/degradation products of atenolol/lisinopril and aspirin, and mechanisms of formation thereof Fulltext Access 10 Pages 2008
Design and synthesis of trans 2-(furan-2-yl)vinyl heteroaromatic iodides with antitumour activity Fulltext Access 10 Pages 2008
Docking analyses on human muscarinic receptors: Unveiling the subtypes peculiarities in agonists binding Fulltext Access 10 Pages 2008
Molecular modeling studies of N-substituted pyrrole derivatives—Potential HIV-1 gp41 inhibitors Fulltext Access 10 Pages 2008
Synthesis and structure–affinity relationships of novel spirocyclic σ receptor ligands with furopyrazole structure Fulltext Access 10 Pages 2008
Achiral, selective CCK2 receptor antagonists based on a 1,3,5-benzotriazepine-2,4-dione template Fulltext Access 10 Pages 2008
Recognition of T·A interruption by 2â²,4â²-BNAs bearing heteroaromatic nucleobases through parallel motif triplex formation Fulltext Access 10 Pages 2008
Exploring the potential of 3′-O-carboxy esters of thymidine as inhibitors of ribonuclease A and angiogenin Fulltext Access 10 Pages 2008
Further structural optimization of cis-(6-benzhydryl-piperidin-3-yl)-benzylamine and 1,4-diazabicyclo[3.3.1]nonane derivatives by introducing an exocyclic hydroxyl group: Interaction with dopamine, serotonin, and norepinephrine transporters Fulltext Access 10 Pages 2008
Inhibitory effects of benzyl benzoate and its derivatives on angiotensin II-induced hypertension Fulltext Access 10 Pages 2008
Development of a receptor-based 3D-QSAR study for the analysis of MMP2, MMP3, and MMP9 inhibitors Fulltext Access 10 Pages 2008
TX-2152: A conformationally rigid and electron-rich diyne analogue of FTY720 with in vivo antiangiogenic activity Fulltext Access 10 Pages 2008
9-N-Substituted berberine derivatives: Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc Fulltext Access 10 Pages 2008
Validated stability-indicating HPLC method for the determination of pridinol mesylate. Kinetics study of its degradation in acid medium Fulltext Access 10 Pages 2008
Synthesis and biological evaluation of new disubstituted analogues of 6-methoxy-3-(3′,4′,5′-trimethoxybenzoyl)-1H-indole (BPR0L075), as potential antivascular agents Fulltext Access 10 Pages 2008
Functionalized pyrrolidine inhibitors of human type II α-mannosidases as anti-cancer agents: Optimizing the fit to the active site Fulltext Access 10 Pages 2008
Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics Fulltext Access 10 Pages 2008
Molecular features of the prazosin molecule required for activation of Transport-P Fulltext Access 10 Pages 2008
Synthesis and evaluation of pyrazolo[3,4-b]pyridines and its structural analogues as TNF-α and IL-6 inhibitors Fulltext Access 10 Pages 2008
Sulfur-substituted naphthalimides as photoactivatable anticancer agents: DNA interaction, fluorescence imaging, and phototoxic effects in cultured tumor cells Fulltext Access 10 Pages 2008
Novel naphthoquinone and quinolinedione inhibitors of CDC25 phosphatase activity with antiproliferative properties Fulltext Access 10 Pages 2008
Naphthylphenstatins as tubulin ligands: Synthesis and biological evaluation Fulltext Access 10 Pages 2008
Distinctive molecular inhibition mechanisms for selective inhibitors of human 11β-hydroxysteroid dehydrogenase type 1 Fulltext Access 10 Pages 2008
A study of the structure–activity relationship of GABAA–benzodiazepine receptor bivalent ligands by conformational analysis with low temperature NMR and X-ray analysis Fulltext Access 10 Pages 2008