Pyrazoles and pyrazolines as neural and inducible nitric oxide synthase (nNOS and iNOS) potential inhibitors (III) Fulltext Access 13 Pages 2008
Quantifying diffusion in mucosal systems by pulsed-gradient spin-echo NMR Fulltext Access 13 Pages 2008
Approaches for the development of solid and semi-solid lipid-based formulations Fulltext Access 13 Pages 2008
Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies Fulltext Access 13 Pages 2008
Albumin as a drug carrier: Design of prodrugs, drug conjugates and nanoparticles Fulltext Access 13 Pages 2008
Insights into the structural requirements of farnesyltransferase inhibitors as potential anti-tumor agents based on 3D-QSAR CoMFA and CoMSIA models Fulltext Access 13 Pages 2008
Xanthine oxidase-activated prodrugs of thymidine phosphorylase inhibitors Fulltext Access 13 Pages 2008
Pharmacophore based discovery of potential antimalarial agent targeting haem detoxification pathway Fulltext Access 13 Pages 2008
Thiazolyl/oxazolyl formazanyl indoles as potent anti-inflammatory agents Fulltext Access 13 Pages 2008
Novel imidazo[1,2-a]naphthyridinic systems (part 1): Synthesis, antiproliferative and DNA-intercalating activities Fulltext Access 13 Pages 2008
Synthesis, computational study and cytotoxic activity of new 4-hydroxycoumarin derivatives Fulltext Access 13 Pages 2008
Synthesis and in vitro biological evaluation of valine-containing prodrugs derived from clinically used HIV-protease inhibitors Fulltext Access 13 Pages 2008
Synthesis, potent anti-staphylococcal activity and QSARs of some novel 2-anilinobenzazoles Fulltext Access 13 Pages 2008
Evaluation of ursolic acid isolated from Ilex paraguariensis and derivatives on aromatase inhibition Fulltext Access 13 Pages 2008
Synthesis, screening for antitubercular activity and 3D-QSAR studies of substituted N-phenyl-6-methyl-2-oxo-4-phenyl-1,2,3,4-tetrahydro-pyrimidine-5-carboxamides Fulltext Access 13 Pages 2008
S-Ribosylhomocysteine analogues with the carbon-5 and sulfur atoms replaced by a vinyl or (fluoro)vinyl unit Fulltext Access 13 Pages 2008
Carboxymethylated pyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling Fulltext Access 13 Pages 2008
Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors Fulltext Access 13 Pages 2008
Recent applications of Chemical Imaging to pharmaceutical process monitoring and quality control Fulltext Access 13 Pages 2008
Sulfamic acid promoted one-pot synthesis of phenanthrene fused-dihydrodibenzo-quinolinones: Anticancer activity, tubulin polymerization inhibition and apoptosis inducing studies Fulltext Access 13 Pages 2008
Absorption-excipient-pH classification gradient maps: Sparingly soluble drugs and the pH partition hypothesis Fulltext Access 13 Pages 2008
In vitro and cell uptake studies for targeting of ligand anchored nanoparticles for colon tumors Fulltext Access 13 Pages 2008
Mechanistic model for the acute effect of fluvoxamine on 5-HT and 5-HIAA concentrations in rat frontal cortex Fulltext Access 13 Pages 2008
Identification of interspecies difference in efflux transporters of hepatocytes from dog, rat, monkey and human Fulltext Access 13 Pages 2008
Novel propellant-driven inhalation formulations: Engineering polar drug particles with surface-trapped hydrofluoroalkane-philes Fulltext Access 13 Pages 2008
Design and study of ibuprofen disintegrating sustained-release tablets comprising coated pellets Fulltext Access 13 Pages 2008
Chitosan–sodium alginate nanoparticles as submicroscopic reservoirs for ocular delivery: Formulation, optimisation and in vitro characterisation Fulltext Access 13 Pages 2008
Drug release property of chitosan–pectinate beads and its changes under the influence of microwave Fulltext Access 13 Pages 2008
Design, synthesis, and biological evaluation of glycine-based molecular tongs as inhibitors of Aβ1–40 aggregation in vitro Fulltext Access 13 Pages 2008
Effect of the spraying conditions and nozzle design on the shape and size distribution of particles obtained with supercritical fluid drying Fulltext Access 13 Pages 2008
Mechanistic understanding of time-dependent oral absorption based on gastric motor activity in humans Fulltext Access 13 Pages 2008
Release characteristics and in vitro–in vivo correlation of pulsatile pattern for a pulsatile drug delivery system activated by membrane rupture via osmotic pressure and swelling Fulltext Access 13 Pages 2008
Preparation, characterization and in vitro cytotoxicity of indomethacin-loaded PLLA/PLGA microparticles using supercritical CO2 technique Fulltext Access 13 Pages 2008
Polyethylenimine PEI F25-LMW allows the long-term storage of frozen complexes as fully active reagents in siRNA-mediated gene targeting and DNA delivery Fulltext Access 13 Pages 2008
Characterisation and controlled drug release from novel drug-loaded hydrogels Fulltext Access 13 Pages 2008
Efficient construction of therapeutics, bioconjugates, biomaterials and bioactive surfaces using azide–alkyne “click” chemistry Fulltext Access 13 Pages 2008
Multifunctional envelope-type nano device (MEND) as a non-viral gene delivery system Fulltext Access 13 Pages 2008
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers Fulltext Access 13 Pages 2008
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14α-demethylase (CYP51) Fulltext Access 13 Pages 2008
Synthesis, biological evaluation, and molecular modeling investigation of chiral 2-(4-chloro-phenoxy)-3-phenyl-propanoic acid derivatives with PPARα and PPARγ agonist activity Fulltext Access 13 Pages 2008
Structural requirements of pyrido[2,3-d]pyrimidin-7-one as CDK4/D inhibitors: 2D autocorrelation, CoMFA and CoMSIA analyses Fulltext Access 13 Pages 2008
Novel triterpenoid from Citrus aurantium L. possesses chemopreventive properties against human colon cancer cells Fulltext Access 13 Pages 2008
Synthesis, induced-fit docking investigations, and in vitro aldose reductase inhibitory activity of non-carboxylic acid containing 2,4-thiazolidinedione derivatives Fulltext Access 13 Pages 2008
Design, synthesis and biological evaluation of bis(hydroxyphenyl) azoles as potent and selective non-steroidal inhibitors of 17β-hydroxysteroid dehydrogenase type 1 (17β-HSD1) for the treatment of estrogen-dependent diseases Fulltext Access 13 Pages 2008
Novel azolyl-(phenylmethyl)]aryl/heteroarylamines: Potent CYP26 inhibitors and enhancers of all-trans retinoic acid activity in neuroblastoma cells Fulltext Access 13 Pages 2008
Structure–activity relationships of new inhibitors of breast cancer resistance protein (ABCG2) Fulltext Access 13 Pages 2008
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels–Alder reactions Fulltext Access 13 Pages 2008
Achiral oligoamines as versatile tool for the development of aspartic protease inhibitors Fulltext Access 13 Pages 2008
Nucleosides and oligonucleotides containing 1,2,3-triazole residues with nucleobase tethers: Synthesis via the azide-alkyne ‘click’ reaction Fulltext Access 13 Pages 2008
Bisphosphonated fluoroquinolone esters as osteotropic prodrugs for the prevention of osteomyelitis Fulltext Access 13 Pages 2008
A comparative molecular field and comparative molecular similarity indices analyses (CoMFA and CoMSIA) of N-phenyl-N′-(2-chloroethyl)ureas targeting the colchicine-binding site as anticancer agents Fulltext Access 13 Pages 2008
5,5,6-Fused tricycles bearing imidazole and pyrazole 6-methylidene penems as broad-spectrum inhibitors of β-lactamases Fulltext Access 13 Pages 2008
N6-substituted C5â²-modified adenosines as A1 adenosine receptor agonists Fulltext Access 13 Pages 2008
Design, synthesis, and biological evaluation of Mannich bases of heterocyclic chalcone analogs as cytotoxic agents Fulltext Access 13 Pages 2008
Discovery and stereoselective synthesis of the novel isochroman neurokinin-1 receptor antagonist ‘CJ-17,493’ Fulltext Access 13 Pages 2008
Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist Fulltext Access 13 Pages 2008
Novel piperidinylpyrimidine derivatives as inhibitors of HIV-1 LTR activation Fulltext Access 13 Pages 2008
Structure–activity relationships of natural and non-natural amino acid-based amide and 2-oxoamide inhibitors of human phospholipase A2 enzymes Fulltext Access 13 Pages 2008
Systematic screening and characterization of flavonoid glycosides in Carthamus tinctorius L. by liquid chromatography/UV diode-array detection/electrospray ionization tandem mass spectrometry Fulltext Access 13 Pages 2008
New practical algorithm for modelling analyte recovery in bioanalytical reversed phase and mixed-mode solid phase extraction Fulltext Access 13 Pages 2008
Determination of aromatic amines in hair dye and henna samples by ion-pair extraction and gas chromatography–mass spectrometry Fulltext Access 13 Pages 2008
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17α-hydroxylase-17,20-lyase (CYP17)—Part II: Core rigidification and influence of substituents at the methylene bridge Fulltext Access 13 Pages 2008
Synthesis and structure–activity relationships of N-{1-[(6-fluoro-2-naphthyl)methyl]piperidin-4-yl}benzamide derivatives as novel CCR3 antagonists Fulltext Access 13 Pages 2008
Single nucleotide specific detection of DNA by native chemical ligation of fluorescence labeled PNA-probes Fulltext Access 13 Pages 2008
Novel pyrazolo[1,5-a]pyrimidines as c-Src kinase inhibitors that reduce IKr channel blockade Fulltext Access 13 Pages 2008
The number and distances of positive charges of polyamine side chains in a series of perylene diimides significantly influence their ability to induce G-quadruplex structures and inhibit human telomerase Fulltext Access 13 Pages 2008
Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABAA receptors Fulltext Access 13 Pages 2008
Synthesis, biological evaluation and molecular modelling of N-heterocyclic dipeptide aldehydes as selective calpain inhibitors Fulltext Access 13 Pages 2008
Synthesis, analgesic, anti-inflammatory, and antimicrobial activity of some novel pyrimido[4,5-b]quinolin-4-ones Fulltext Access 13 Pages 2008
Core-modified porphyrins. Part 6: Effects of lipophilicity and core structures on physicochemical and biological properties in vitro Fulltext Access 13 Pages 2008
Hepatitis C virus NS3 protease inhibitors comprising a novel aromatic P1 moiety Fulltext Access 13 Pages 2008
Synthesis of stable and selective inhibitors of human galectins-1 and -3 Fulltext Access 13 Pages 2008
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 2: Parallel synthesis, molecular modelling and structure–activity relationship studies on analogues of O-(2-phenylethyl)-N-phenylthiocarbamate Fulltext Access 13 Pages 2008
Thiocarbamates as non-nucleoside HIV-1 reverse transcriptase inhibitors. Part 1: Parallel synthesis, molecular modelling and structure–activity relationship studies on O-[2-(hetero)arylethyl]-N-phenylthiocarbamates Fulltext Access 13 Pages 2008
A binary QSAR model for classification of hERG potassium channel blockers Fulltext Access 13 Pages 2008
N-1H-Benzimidazol-5-ylbenzenesulfonamide derivatives as potent hPXR agonists Fulltext Access 13 Pages 2008
Halogenated derivatives QSAR model using spectral moments to predict haloacetic acids (HAA) mutagenicity Fulltext Access 13 Pages 2008
Pharmacological and pharmacokinetic characterization of 2-piperazine-α-isopropyl benzylamine derivatives as melanocortin-4 receptor antagonists Fulltext Access 13 Pages 2008
The pyridoxamine action on Amadori compounds: A reexamination of its scavenging capacity and chelating effect Fulltext Access 13 Pages 2008
Evaluation of the amino acid binding site of Mycobacterium tuberculosis glutamine synthetase for drug discovery Fulltext Access 13 Pages 2008
Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a Fulltext Access 13 Pages 2008
Synthesis, antitumor evaluation and DNA binding studies of novel amidino-benzimidazolyl substituted derivatives of furyl-phenyl- and thienyl-phenyl-acrylates, naphthofurans and naphthothiophenes Fulltext Access 14 Pages 2008
Synthesis and evaluation of a focused library of pyridine dicarbonitriles against prion disease Fulltext Access 14 Pages 2008