3D-QSAR models on clinically relevant K103N mutant HIV-1 reverse transcriptase obtained from two strategic considerations Fulltext Access 14 Pages 2008
SAR studies of capsazepinoid bronchodilators. Part 1: The importance of the catechol moiety and aspects of the B-ring structure Fulltext Access 14 Pages 2008
α- and β-Substituted phosphonate analogs of LPA as autotaxin inhibitors Fulltext Access 14 Pages 2008
4-(Anilino)pyrrole-2-carboxamides: Novel non-steroidal/non-anilide type androgen antagonists effective upon human prostate tumor LNCaP cells with mutated nuclear androgen receptor Fulltext Access 14 Pages 2008
A re-examination of the difluoromethylenesulfonic acid group as a phosphotyrosine mimic for PTP1B inhibition Fulltext Access 14 Pages 2008
Co-existence of α-glucosidase-inhibitory and liver X receptor-regulatory activities and their separation by structural development Fulltext Access 14 Pages 2008
Degradation-promoters of cellular inhibitor of apoptosis protein 1 based on bestatin and actinonin Fulltext Access 14 Pages 2008
Structure–activity studies on 1,3-dioxane-2-carboxylic acid derivatives, a novel class of subtype-selective peroxisome proliferator-activated receptor α (PPARα) agonists Fulltext Access 14 Pages 2008
Novel analogs of d-e-MAPP and B13. Part 2: Signature effects on bioactive sphingolipids Fulltext Access 14 Pages 2008
Synthesis and pharmacology of 1-deoxy analogs of CP-47,497 and CP-55,940 Fulltext Access 14 Pages 2008
Acridones circumvent P-glycoprotein-associated multidrug resistance (MDR) in cancer cells Fulltext Access 14 Pages 2008
Pharmacokinetics of Pâglycoprotein inhibition in the rat bloodâbrain barrier Fulltext Access 15 Pages 2008
Effect of pH on Stability of Recombinant Botulinum Serotype A Vaccine in Aqueous Solution and During Storage of FreezeâDried Formulations Fulltext Access 15 Pages 2008
Transdermal delivery of penetrants with differing lipophilicities using O-acylmenthol derivatives as penetration enhancers Fulltext Access 15 Pages 2008
Process Induced Disorder in Crystalline Materials:Differentiating Defective Crystals from the Amorphous Form of Griseofulvin Fulltext Access 15 Pages 2008
Quality by Design, Part II: Application of NIR Spectroscopy to Monitor the Coating Process for a Pharmaceutical Sustained Release Product Fulltext Access 15 Pages 2008
The Molecular Interactions That Influence the Plasticizer Dependent Dissolution of Acrylic Polymer Films Fulltext Access 15 Pages 2008
The CoâCrystal Approach to Improve the Exposure of a WaterâInsoluble Compound: AMG 517 Sorbic Acid CoâCrystal Characterization and Pharmacokinetics Fulltext Access 15 Pages 2008
Overall Monotropic Behavior of a Metastable Phase of Biclotymol, 2,2â²-Methylenebis(4-Chloro-3-Methyl-Isopropylphenol), Inferred From Experimental and Topological Construction of the Related P-T State Diagram Fulltext Access 15 Pages 2008
Stable-Form Screening: Overcoming Trace Impurities That Inhibit Solution-Mediated Phase Transformation to the Stable Polymorph of Sulfamerazine Fulltext Access 15 Pages 2008
SiteâSpecific Drug Delivery to the Middle Region of the Small Intestine by Application of Enteric Coating with Hypromellose Acetate Succinate (HPMCAS) Fulltext Access 15 Pages 2008
Pharmacokinetic/pharmacodynamic modelling of the EEG effects of opioids: The role of complex biophase distribution kinetics Fulltext Access 15 Pages 2008
Polymer coating of quantum dots – A powerful tool toward diagnostics and sensorics Fulltext Access 15 Pages 2008
Non-viral gene transfection technologies for genetic engineering of stem cells Fulltext Access 15 Pages 2008
Coprocessing via spray drying as a formulation platform to improve the compactability of various drugs Fulltext Access 15 Pages 2008
Methoxy poly(ethylene glycol) – Low molecular weight linear polyethylenimine-derived copolymers enable polyplex shielding Fulltext Access 15 Pages 2008
Biochemical Investigation of Active Intracellular Transport of Polymeric Gene-Delivery Vectors Fulltext Access 15 Pages 2008
An evaluation of the validity of inferences made from 3 diabetes assessment instruments: A Rasch analysis Fulltext Access 15 Pages 2008
Development of a measure to assess pharmacy students' beliefs about monitoring chronic diseases Fulltext Access 15 Pages 2008
Nature and consequences of protein–protein interactions in high protein concentration solutions Fulltext Access 15 Pages 2008
Safety assessment of diammonium phosphate and urea used in the manufacture of cigarettes Fulltext Access 15 Pages 2008
Cranberry juice for prophylaxis of urinary tract infections – Conclusions from clinical experience and research Fulltext Access 15 Pages 2008
Physicochemical characterization and release mechanism of a novel prednisone biodegradable microsphere formulation Fulltext Access 15 Pages 2008
Conformational Stability of Ibuprofen: Assessed by DFT Calculations and Optical Vibrational Spectroscopy Fulltext Access 15 Pages 2008
Complexation and Chiral Drug Recognition of an Amphiphilic Phenothiazine Derivative with βâCyclodextrin Fulltext Access 15 Pages 2008
The Transient Dermal Exposure: Theory and Experimental Examples Using Skin and Silicone Membranes Fulltext Access 15 Pages 2008
Brain uptake of an anti-ischemic agent by nasal administration of microparticles Fulltext Access 15 Pages 2008
Particle diffusional layer thickness in a USP dissolution apparatus II: A combined function of particle size and paddle speed Fulltext Access 15 Pages 2008
Adsorption and function of recombinant factor VIII at solid-water interfaces in the presence of Tween-80 Fulltext Access 15 Pages 2008
PEGylation as a tool for the biomedical engineering of surface modified microparticles Fulltext Access 15 Pages 2008
Process Analytical Technology (PAT): Quantification Approaches in Terahertz Spectroscopy for Pharmaceutical Application* Fulltext Access 15 Pages 2008
Synthesis and Characterization of Biodegradable Networks Providing Saturated-Solution Prolonged Delivery Fulltext Access 15 Pages 2008
Fused bicyclic pyrrolizinones as new scaffolds for human NK1 antagonists Fulltext Access 15 Pages 2008
Recommendations for the validation of immunoassays used for detection of host antibodies against biotechnology products Fulltext Access 15 Pages 2008
Synthesis and antihypertensive effects of new methylthiomorpholinphenol derivatives Fulltext Access 15 Pages 2008
Total syntheses of (±)-ovalicin, C4(S∗)-isomer, and its C5-analogs and anti-trypanosomal activities Fulltext Access 15 Pages 2008
Synthesis and structure–activity relationship of histone deacetylase (HDAC) inhibitors with triazole-linked cap group Fulltext Access 15 Pages 2008
RCAI-8, 9, 18, 19, and 49–52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce cytokines Fulltext Access 15 Pages 2008
Functional assay and structure–activity relationships of new third-generation P-glycoprotein inhibitors Fulltext Access 15 Pages 2008
Structural requirements for the stability of novel cephalosporins to AmpC β-lactamase based on 3D-structure Fulltext Access 15 Pages 2008
Synthesis of N-(5,7-diamino-3-phenyl-quinoxalin-2-yl)-3,4,5-substituted anilines and N-[4[(5,7-diamino-3-phenylquinoxalin-2-yl)amino]benzoyl]-l-glutamic acid diethyl ester: Evaluation of in vitro anti-cancer and anti-folate activities Fulltext Access 15 Pages 2008
QSAR modeling of the antifungal activity against Candida albicans for a diverse set of organic compounds Fulltext Access 15 Pages 2008
Synthesis and evaluation of homodimeric GnRHR antagonists having a rigid bis-propargylated benzene core Fulltext Access 15 Pages 2008
Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens Fulltext Access 15 Pages 2008
Design, synthesis and biological evaluation of substituted pyrrolo[2,3-d]pyrimidines as multiple receptor tyrosine kinase inhibitors and antiangiogenic agents Fulltext Access 15 Pages 2008
Design and evaluation of a novel series of 2,3-oxidosqualene cyclase inhibitors with low systemic exposure, relationship between pharmacokinetic properties and ocular toxicity Fulltext Access 15 Pages 2008
Structure and bioactivity of the polysaccharides in medicinal plant Dendrobium huoshanense Fulltext Access 15 Pages 2008
Introduction of the 4-(4-bromophenyl)benzenesulfonyl group to hydrazide analogs of Ilomastat leads to potent gelatinase B (MMP-9) inhibitors with improved selectivity Fulltext Access 15 Pages 2008
Multicomponent reactions in fungicide research: The discovery of mandipropamid Fulltext Access 15 Pages 2008
Isolation and characterization of process related impurities and degradation products of bicalutamide and development of RP-HPLC method for impurity profile study Fulltext Access 15 Pages 2008
Isotopic ratios to detect infringements of patents or proprietary processes of pharmaceuticals: Two case studies Fulltext Access 15 Pages 2008
Application of chiral derivatizing agents in the high-performance liquid chromatographic separation of amino acid enantiomers: A review Fulltext Access 15 Pages 2008
Material and tablet properties of pregelatinized (thermally modified) Dioscorea starches Fulltext Access 15 Pages 2008
Pre-formulation of liposomes against Helicobacter pylori: Characterization and interaction with the bacteria Fulltext Access 15 Pages 2008
Applications of supercritical CO2 in the fabrication of polymer systems for drug delivery and tissue engineering Fulltext Access 15 Pages 2008
Pathophysiological and pharmacological implications of mitochondria-targeted reactive oxygen species generation in astrocytes Fulltext Access 15 Pages 2008
Quantum dots and nanoparticles for photodynamic and radiation therapies of cancer Fulltext Access 15 Pages 2008
Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic update Fulltext Access 15 Pages 2008
Design and production of nanoparticles formulated from nano-emulsion templates—A review Fulltext Access 15 Pages 2008
A Biophysical Characterization of the Peptide Drug Pramlintide (AC137) Using Empirical Phase Diagrams Fulltext Access 16 Pages 2008
High Concentration Formulations of Recombinant Human Interleukin-1 Receptor Antagonist: I. Physical Characterization Fulltext Access 16 Pages 2008
Calorimetric and spatial characterization of polymorphic transitions in caffeine using quasiâisothermal MTDSC and localized thermomechanical analysis Fulltext Access 16 Pages 2008
Inhibit multidrug resistance and induce apoptosis by using glycocholic acid and epirubicin Fulltext Access 16 Pages 2008
Retinal electrophysiology for toxicology studies: Applications and limits of ERG in animals and ex vivo recordings Fulltext Access 16 Pages 2008
A Liposome Permeability Model for Stratum Corneum Lipid Bilayers Based on Commercial Lipids Fulltext Access 16 Pages 2008
Development of solid lipid nanoparticles containing ionically complexed chemotherapeutic drugs and chemosensitizers Fulltext Access 16 Pages 2008
Synthesis and in Vitro Characterization of Novel Dextran-Methylprednisolone Conjugates with Peptide Linkers: Effects of Linker Length on Hydrolytic and Enzymatic Release of Methylprednisolone and its Peptidyl Intermediates Fulltext Access 16 Pages 2008
Physicochemical, Crystallographic, Thermal, and Spectroscopic Behavior of Crystalline and X-ray Amorphous Ciclesonide Fulltext Access 16 Pages 2008
Prediction of Drug Tissue to Plasma Concentration Ratios Using a Measured Volume of Distribution in Combination With Lipophilicity Fulltext Access 16 Pages 2008