In-silico model of skin penetration based on experimentally determined input parameters. Part I: Experimental determination of partition and diffusion coefficients Fulltext Access 16 Pages 2008
Quantum dots – Nano-sized probes for the exploration of cellular and intracellular targeting Fulltext Access 16 Pages 2008
Suspensions for intravenous (IV) injection: A review of development, preclinical and clinical aspects Fulltext Access 16 Pages 2008
Poly (amino acid) micelle nanocarriers in preclinical and clinical studies Fulltext Access 16 Pages 2008
Site-specific modification and PEGylation of pharmaceutical proteins mediated by transglutaminase Fulltext Access 16 Pages 2008
Resistance against novel anticancer metal compounds: Differences and similarities Fulltext Access 16 Pages 2008
Advanced screening assays to rapidly identify solubility-enhancing formulations: High-throughput, miniaturization and automation Fulltext Access 16 Pages 2008
Synthesis, determination of the lipophilicity, anticancer and antimicrobial properties of some fused 1,2,4-triazole derivatives Fulltext Access 16 Pages 2008
1,8-Naphthyridines VII. New substituted 5-amino[1,2,4]triazolo[4,3-a][1,8]naphthyridine-6-carboxamides and their isosteric analogues, exhibiting notable anti-inflammatory and/or analgesic activities, but no acute gastrolesivity Fulltext Access 16 Pages 2008
6-Substituted 2-oxo-2H-1-benzopyran-3-carboxylic acid derivatives in a new approach of the treatment of cancer cell invasion and metastasis Fulltext Access 16 Pages 2008
Crystal Structure of Minoxidil at Low Temperature and Polymorph Prediction Fulltext Access 16 Pages 2008
Partitioning, diffusivity and clearance of skin permeants in mammalian dermis Fulltext Access 16 Pages 2008
Effect of surface charge and density of distearylphosphatidylethanolamine-mPEG-2000 (DSPE-mPEG-2000) on the cytotoxicity of liposome-entrapped ricin: Effect of lysosomotropic agents Fulltext Access 16 Pages 2008
Interaction of lipid nanoparticles with human epidermis and an organotypic cell culture model Fulltext Access 16 Pages 2008
Trileucine Improves Aerosol Performance and Stability of Spray‐Dried Powders for Inhalation Fulltext Access 16 Pages 2008
Use of plasma proteins as solubilizing agents in in vitro permeability experiments: Correction for unbound drug concentration using the reciprocal permeability approach Fulltext Access 16 Pages 2008
Stability and Hydrolysis Kinetics of Spirosuccinimide type Inhibitors of Aldose Reductase in Aqueous Solution and Retardation of Their Hydrolysis by the Target enzyme Fulltext Access 16 Pages 2008
Rapid Throughput Solubility Screening Method for BCS Class II Drugs in Animal GI Fluids and Simulated Human GI Fluids Using a 96âwell Format Fulltext Access 16 Pages 2008
Thiopyrano[2,3-e]indol-2-ones: Angelicin heteroanalogues with potent photoantiproliferative activity Fulltext Access 16 Pages 2008
Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity Fulltext Access 16 Pages 2008
Nanoparticulate biopolymers deliver insulin orally eliciting pharmacological response Fulltext Access 16 Pages 2008
Formulation Development and Process Scale Up of a High Shear Wet Granulation Formulation Containing a Poorly Wettable Drug Fulltext Access 16 Pages 2008
Solid state chemistry of proteins: II. The correlation of storage stability of freezeâdried human growth hormone (hGH) with structure and dynamics in the glassy solid Fulltext Access 16 Pages 2008
Characterization of Spreadability of Nonaqueous Ethylcellulose Gel Matrices Using Dynamic Contact Angle Fulltext Access 16 Pages 2008
Characterization of Pharmaceutical Powder Blends by NIR Chemical Imaging Fulltext Access 16 Pages 2008
Effects of Annealing on Enthalpy Relaxation in Lyophilized Disaccharide Formulations: Mathematical Modeling of DSC Curves Fulltext Access 16 Pages 2008
SPARC in cancer biology: Its role in cancer progression and potential for therapy Fulltext Access 16 Pages 2008
Chemical synthesis of 2β-amino-5α-androstane-3α,17β-diol N-derivatives and their antiproliferative effect on HL-60 human leukemia cells Fulltext Access 16 Pages 2008
Synthesis and pharmacological evaluation of bicyclic SNC80 analogues with separated benzhydryl moiety Fulltext Access 16 Pages 2008
New R/S-3,4-dihydro-2,2-dimethyl-6-halo-4-(phenylaminothiocarbonylamino)-2H-1-benzopyrans structurally related to (±)-cromakalim as tissue-selective pancreatic β-cell KATP channel openers Fulltext Access 16 Pages 2008
β-Amino acid substitutions and structure-based CoMFA modeling of hepatitis C virus NS3 protease inhibitors Fulltext Access 16 Pages 2008
Design, synthesis and SAR of potent statine-based BACE-1 inhibitors: Exploration of P1 phenoxy and benzyloxy residues Fulltext Access 16 Pages 2008
Discovery of piperazinylimidazo[1,2-a]pyridines as novel S4 binding elements for orally active Factor Xa inhibitors Fulltext Access 16 Pages 2008
2-Substituted-16-ene-22-thia-1α,25-dihydroxy-26,27-dimethyl-19-norvitamin D3 analogs: Synthesis, biological evaluation, and crystal structure Fulltext Access 16 Pages 2008
Parallel synthesis of a series of potentially brain penetrant aminoalkyl benzoimidazoles Fulltext Access 16 Pages 2008
Stereospecific synthesis and bio-activity of novel β3-adrenoceptor agonists and inverse agonists Fulltext Access 16 Pages 2008
SAR studies of capsazepinoid bronchodilators. Part 2: Chlorination and catechol replacement in the A-ring Fulltext Access 16 Pages 2008
Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (2) Fulltext Access 16 Pages 2008
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment Fulltext Access 16 Pages 2008
2D QSAR and similarity studies on cruzain inhibitors aimed at improving selectivity over cathepsin L Fulltext Access 16 Pages 2008
Trivalent, Gal/GalNAc-containing ligands designed for the asialoglycoprotein receptor Fulltext Access 16 Pages 2008
Quality assessment of fluoxetine and fluvoxamine pharmaceutical formulations purchased in different countries or via the Internet by 19F and 2D DOSY 1H NMR Fulltext Access 16 Pages 2008
Non-ATP competitive glycogen synthase kinase 3β (GSK-3β) inhibitors: Study of structural requirements for thiadiazolidinone derivatives Fulltext Access 16 Pages 2008
Synthesis of guanidino analogues of PMPDAP and their immunobiological activity Fulltext Access 16 Pages 2008
A novel series of parenteral cephalosporins exhibiting potent activities against both Pseudomonas aeruginosa and other Gram-negative pathogens. Part 2: Synthesis and structure–activity relationships Fulltext Access 16 Pages 2008
Characterization of amorphous API:Polymer mixtures using X-ray powder diffraction Fulltext Access 17 Pages 2008
Design, synthesis and biological evaluation of piperazine analogues as CB1 cannabinoid receptor ligands Fulltext Access 17 Pages 2008
Heteroaromatic ester inhibitors of hepatitis A virus 3C proteinase: Evaluation of mode of action Fulltext Access 17 Pages 2008
Formulation strategies to minimize oxidative damage in lyophilized lipid/DNA complexes during storage Fulltext Access 17 Pages 2008
Inhibitors of tubulin polymerization: Synthesis and biological evaluation of hybrids of vindoline, anhydrovinblastine and vinorelbine with thiocolchicine, podophyllotoxin and baccatin III Fulltext Access 17 Pages 2008
Study of the Individual Contributions of Ice Formation and Freeze-Concentration on Isothermal Stability of Lactate Dehydrogenase during Freezing Fulltext Access 17 Pages 2008
Synthesis, ligand–receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists Fulltext Access 17 Pages 2008
Synthesis, characterization and antiproliferative studies of the enantiomers of cis-[(1,2-camphordiamine)dichloro]platinum(II) complexes Fulltext Access 17 Pages 2008
Establishing quantitative in-line analysis of multiple solid-state transformations during dehydration Fulltext Access 17 Pages 2008
Synthesis, α1-adrenoceptor antagonist activity, and SAR study of novel arylpiperazine derivatives of phenytoin Fulltext Access 17 Pages 2008
Synthesis and evaluation of xanomeline analogs—Probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor Fulltext Access 17 Pages 2008
Bioinspired tissue engineering: The great promise of protein delivery technologies Fulltext Access 17 Pages 2008
Influence of sulfur oxidation state and steric bulk upon trifluoromethyl ketone (TFK) binding kinetics to carboxylesterases and fatty acid amide hydrolase (FAAH) Fulltext Access 17 Pages 2008
Engineering Biodegradable Polyester Particles With Specific Drug Targeting and Drug Release Properties Fulltext Access 17 Pages 2008
Novel 2-phenylquinolin-7-yl-derived imidazo[1,5-a]pyrazines as potent insulin-like growth factor-I receptor (IGF-IR) inhibitors Fulltext Access 17 Pages 2008
Solid State Interconversion Between Anhydrous Norfloxacin and Its Hydrates Fulltext Access 17 Pages 2008
Synthesis and antiplatelet activity of ethyl 4-(1-benzyl-1H-indazol-3-yl)benzoate (YD-3) derivatives Fulltext Access 17 Pages 2008
Polymers and nanoparticles: Intelligent tools for intracellular targeting? Fulltext Access 17 Pages 2008
Synthesis and cytotoxic properties of new fluorodeoxyglucose-coupled chlorambucil derivatives Fulltext Access 17 Pages 2008
Prediction of HIV-1 protease inhibitor resistance by Molecular Modeling Protocols (MMPs) using GenMol⢠software Fulltext Access 17 Pages 2008
QSAR study on tetrahydroquinoline analogues as plasmodium protein farnesyltransferase inhibitors: A comparison of rationales of malarial and mammalian enzyme inhibitory activities for selectivity Fulltext Access 17 Pages 2008
2-Methylene 19-nor-25-dehydro-1α-hydroxyvitamin D3 26,23-lactones: Synthesis, biological activities and molecular basis of passive antagonism Fulltext Access 17 Pages 2008
Nano/micro technologies for delivering macromolecular therapeutics using poly(d,l-lactide-co-glycolide) and its derivatives Fulltext Access 17 Pages 2008
Novel analogs of d-e-MAPP and B13. Part 1: Synthesis and evaluation as potential anticancer agents Fulltext Access 17 Pages 2008
Predicting drug disposition, absorption/elimination/transporter interplay and the role of food on drug absorption Fulltext Access 17 Pages 2008
Affinity purification and characterization of a key enzyme responsible for circadian rhythmic control of nyctinasty in Lespedeza cuneata L Fulltext Access 17 Pages 2008
Biocompatible poly(methylidene malonate)-made materials for pharmaceutical and biomedical applications Fulltext Access 17 Pages 2008
Nano-Sized Assemblies of a PEG-Docetaxel Conjugate as a Formulation Strategy for Docetaxel Fulltext Access 17 Pages 2008
Novel 2-(4-methylsulfonylphenyl)pyrimidine derivatives as highly potent and specific COX-2 inhibitors Fulltext Access 17 Pages 2008
Studies toward the discovery of the next generation of antidepressants. Part 6: Dual 5-HT1A receptor and serotonin transporter affinity within a class of arylpiperazinyl-cyclohexyl indole derivatives Fulltext Access 17 Pages 2008
The Pharmacology of PEGylation: Balancing PD with PK to Generate Novel Therapeutics Fulltext Access 17 Pages 2008
Preparation and Characterisation of Natamycin: γ-Cyclodextrin Inclusion Complex and its Evaluation in Vaginal Mucoadhesive Formulations Fulltext Access 17 Pages 2008
A Quick Method for the Quantitative Analysis of Mixtures. 1. Powder X-Ray Diffraction Fulltext Access 17 Pages 2008
Characterisation of Chitosan-Coated Vesicles Encapsulating DNA Suitable for Gene Delivery Fulltext Access 17 Pages 2008
High Concentration Formulations of Recombinant Human Interleukin-1 Receptor Antagonist: II. Aggregation Kinetics Fulltext Access 17 Pages 2008
Effects of Physiological Fluids on Physical-Chemical Characteristics and Activity of Topical Vaginal Microbicide Products Fulltext Access 17 Pages 2008
Ketotifen-Loaded Microspheres Prepared by Spray-Drying Poly (D,L-Lactide) and Poly(D,L-Lactide-co-Glycolide) Polymers: Characterization and In Vivo Evaluation Fulltext Access 17 Pages 2008
Liposomes Incorporating a Plasmodium Amino Acid Sequence Target Heparan Sulfate Binding Sites in Liver Fulltext Access 17 Pages 2008
New QSAR combined strategy for the design of A1 adenosine receptor agonists Fulltext Access 18 Pages 2008