Synthesis and topoisomerase poisoning activity of A-ring and E-ring substituted luotonin A derivatives Fulltext Access 10 Pages 2007
Selective inhibition of the interaction of C1q with immunoglobulins and the classical pathway of complement activation by steroids and triterpenoids sulfates Fulltext Access 10 Pages 2007
Synthesis and in vivo evaluation of non-hepatotoxic acetaminophen analogs Fulltext Access 10 Pages 2007
Synthesis and antimycobacterial evaluation of benzofurobenzopyran analogues Fulltext Access 10 Pages 2007
Development of selective inhibitors for anti-apoptotic Bcl-2 proteins from BHI-1 Fulltext Access 10 Pages 2007
A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors Fulltext Access 10 Pages 2007
Free radical trapping properties of several ethyl-substituted derivatives of 5-ethoxycarbonyl-5-methyl-1-pyrroline N-oxide (EMPO) Fulltext Access 10 Pages 2007
Synthesis and biological evaluation of new 3-substituted indole derivatives as potential anti-inflammatory and analgesic agents Fulltext Access 10 Pages 2007
Synthesis and crystallographic analysis of benzophenone derivatives—The potential anti-inflammatory agents Fulltext Access 10 Pages 2007
Synthesis and biological evaluation of new 6-s-cis locked 1,2,25-trihydroxyprevitamin D3 analogues Fulltext Access 10 Pages 2007
Probing the receptor interactions of an H5 avian influenza virus using a baculovirus expression system and functionalised poly(acrylic acid) ligands Fulltext Access 10 Pages 2007
Zinc-(II) 2,9,16,23-tetrakis (methoxy) phthalocyanine: Potential photosensitizer for use in photodynamic therapy in vitro Fulltext Access 10 Pages 2007
Explaining cyclodextrin–mycotoxin interactions using a ‘natural’ force field Fulltext Access 10 Pages 2007
Synthesis and biological activity of nociceptin/orphanin FQ analogues substituted in position 7 or 11 with Cα,α-dialkylated amino acids Fulltext Access 10 Pages 2007
β-Keto sulfones as inhibitors of 11β-hydroxysteroid dehydrogenase type I and the mechanism of action Fulltext Access 10 Pages 2007
Synthesis and bioactivities of 6,7,8-trimethoxy-N-aryl-4-aminoquinazoline derivatives Fulltext Access 10 Pages 2007
Identification, biological activity, and mechanism of the anti-ischemic quinolone analog Fulltext Access 10 Pages 2007
Synthesis and evaluation of isosteres of N-methyl indolo[3,2-b]-quinoline (cryptolepine) as new antiinfective agents Fulltext Access 10 Pages 2007
Combined 3D QSAR and molecular docking studies to reveal novel cannabinoid ligands with optimum binding activity Fulltext Access 10 Pages 2007
Carbonic anhydrase inhibitors: The β-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors Fulltext Access 10 Pages 2007
Discovery of cyclopentane- and cyclohexane-trans-1,3-diamines as potent melanin-concentrating hormone receptor 1 antagonists Fulltext Access 10 Pages 2007
The discovery of 6-amino nicotinamides as potent and selective histone deacetylase inhibitors Fulltext Access 10 Pages 2007
Quantitative structure–activity relationship studies for prediction of antimicrobial activity of synthesized 2,4-hexadienoic acid derivatives Fulltext Access 10 Pages 2007
Molecular modeling of some 1H-benzimidazole derivatives with biological activity against Entamoeba histolytica: A comparative molecular field analysis study Fulltext Access 10 Pages 2007
Synthesis of a new class of 2-anilino substituted nicotinyl arylsulfonylhydrazides as potential anticancer and antibacterial agents Fulltext Access 10 Pages 2007
The novel C-5 aryl, alkenyl, and alkynyl substituted uracil derivatives of l-ascorbic acid: Synthesis, cytostatic, and antiviral activity evaluations Fulltext Access 10 Pages 2007
Hyphenation of Raman spectroscopy with gravimetric analysis to interrogate water-solid interactions in pharmaceutical systems Fulltext Access 10 Pages 2007
Synthesis of 11C-labelled (R)-OHDMI and CFMME and their evaluation as candidate radioligands for imaging central norepinephrine transporters with PET Fulltext Access 10 Pages 2007
Molecular modeling of binding between amidinobenzisothiazoles, with antidegenerative activity on cartilage, and matrix metalloproteinase-3 Fulltext Access 10 Pages 2007
Substrate specificity analysis and inhibitor design of homoisocitrate dehydrogenase Fulltext Access 10 Pages 2007
Highly potent 3-pyrroline mechanism-based inhibitors of bovine plasma amine oxidase and mass spectrometric confirmation of cofactor derivatization Fulltext Access 10 Pages 2007
Structural and mechanistic insights into the action of Plasmodium falciparum spermidine synthase Fulltext Access 10 Pages 2007
Heme oxygenase inhibition by 2-oxy-substituted 1-(1H-imidazol-1-yl)-4-phenylbutanes: Effect of halogen substitution in the phenyl ring Fulltext Access 10 Pages 2007
Synthesis and preliminary pharmacological evaluation of the four stereoisomers of (2S)-2-(2′-phosphono-3′-phenylcyclopropyl)glycine, the first class of 3′-substituted transC1′−2′-2-(2′-phosphonocyclopropyl)glycines Fulltext Access 10 Pages 2007
Synthesis of β-ketophosphonate analogs of glutamyl and glutaminyl adenylate, and selective inhibition of the corresponding bacterial aminoacyl-tRNA synthetases Fulltext Access 10 Pages 2007
Structure–activity relationships of methoctramine-related polyamines as muscarinic antagonist: Effect of replacing the inner polymethylene chain with cyclic moieties Fulltext Access 10 Pages 2007
Antiproliferative, low-calcemic, fluorinated sulfone analogs of 1α,25-dihydroxyvitamin D3: Chemical synthesis and biological evaluation Fulltext Access 10 Pages 2007
Synthesis and biological evaluation of imidazo[1,2-a]pyridine derivatives as novel PI3 kinase p110α inhibitors Fulltext Access 10 Pages 2007
Synthesis, anti-HIV activity, and resistance profile of thymidine phosphonomethoxy nucleosides and their bis-isopropyloxymethylcarbonyl (bisPOC) prodrugs Fulltext Access 10 Pages 2007
Synthesis, anticancer, and cytotoxic activities of some mononuclear Ru(II) compounds Fulltext Access 10 Pages 2007
Inhibition of the Mycobacterium tuberculosis enoyl acyl carrier protein reductase InhA by arylamides Fulltext Access 10 Pages 2007
Replacement of the lactone moiety on podophyllotoxin and steganacin analogues with a 1,5-disubstituted 1,2,3-triazole via ruthenium-catalyzed click chemistry Fulltext Access 10 Pages 2007
Reactivity of dimethyl fumarate and methylhydrogen fumarate towards glutathione and N-acetyl-l-cysteine—Preparation of S-substituted thiosuccinic acid esters Fulltext Access 10 Pages 2007
Synthesis and biophysical evaluation of minor-groove binding C-terminus modified pyrrole and imidazole triamide analogs of distamycin Fulltext Access 10 Pages 2007
The influence of modifications in imide fragment structure on 5-HT1A and 5-HT7 receptor affinity and in vivo pharmacological properties of some new 1-(m-trifluoromethylphenyl)piperazines Fulltext Access 10 Pages 2007
Synthesis and biological evaluation of phenolic Mannich bases of benzaldehyde and (thio)semicarbazone derivatives against the cysteine protease falcipain-2 and a chloroquine resistant strain of Plasmodium falciparum Fulltext Access 10 Pages 2007
Synthesis of Tc-99m labeled glucosamino-Asp-cyclic(Arg-Gly-Asp-d-Phe-Lys) as a potential angiogenesis imaging agent Fulltext Access 10 Pages 2007
Molecular design of histone deacetylase inhibitors by aromatic ring shifting in chlamydocin framework Fulltext Access 10 Pages 2007
Antiprotozoal and antimicrobial activities of O-alkylated and formylated acylphloroglucinols Fulltext Access 10 Pages 2007
Synthesis of 5-deazaflavin derivatives and their activation of p53 in cells Fulltext Access 10 Pages 2007
Photomodulation of PS-modified oligonucleotides containing azobenzene substituent at pre-selected positions in phosphate backbone Fulltext Access 10 Pages 2007
A new hydrophilic interaction liquid chromatographic (HILIC) procedure for the simultaneous determination of pseudoephedrine hydrochloride (PSH), diphenhydramine hydrochloride (DPH) and dextromethorphan hydrobromide (DXH) in cough-cold formulations Fulltext Access 10 Pages 2007
Simultaneous determination of monodesethylchloroquine, chloroquine, cycloguanil and proguanil on dried blood spots by reverse-phase liquid chromatography Fulltext Access 10 Pages 2007
Raman spectroscopy of coated pharmaceutical tablets and physical models for multivariate calibration to tablet coating thickness Fulltext Access 10 Pages 2007
Enhancement of oral drug absorption—Effect of lipid conjugation on the enzymatic stability and intestinal permeability of l-Glu-l-Trp-NH2 Fulltext Access 10 Pages 2007
Design, synthesis, and docking studies of new 1,3,4-thiadiazole-2-thione derivatives with carbonic anhydrase inhibitory activity Fulltext Access 10 Pages 2007
Optimization of GC–MS conditions based on resolution and stability of analytes for simultaneous determination of nine sesquiterpenoids in three species of Curcuma rhizomes Fulltext Access 10 Pages 2007
Characterization and comparison of the chromatographic performance of different types of reversed-phase stationary phases Fulltext Access 10 Pages 2007
Syntheses and anti-cancer activities of 2-[1-(indol-3-yl-/pyrimidin-5-yl-/pyridine-2-yl-/quinolin-2-yl)-but-3-enylamino]-2-phenyl-ethanols Fulltext Access 10 Pages 2007
Characterization and quantitative determination of impurities in piperaquine phosphate by HPLC and LC/MS/MS Fulltext Access 10 Pages 2007
The molecular pruning of a phosphoramidate peptidomimetic inhibitor of prostate-specific membrane antigen Fulltext Access 10 Pages 2007
Synthesis and biological evaluation of norcantharidin analogues: Towards PP1 selectivity Fulltext Access 10 Pages 2007
Click chemistry based solid phase supported synthesis of dopaminergic phenylacetylenes Fulltext Access 10 Pages 2007
‘Bridged’ stilbene derivatives as selective cyclooxygenase-1 inhibitors Fulltext Access 10 Pages 2007
Chimeric RNase H-competent oligonucleotides directed to the HIV-1 Rev response element Fulltext Access 10 Pages 2007
Investigation on PEGylation strategy of recombinant human interleukin-1 receptor antagonist Fulltext Access 10 Pages 2007
Parallel solid synthesis of inhibitors of the essential cell division FtsZ enzyme as a new potential class of antibacterials Fulltext Access 11 Pages 2007
Specific interactions with intra- and intermolecular G-quadruplex DNA structures by hydrosoluble coronene derivatives: A new class of telomerase inhibitors Fulltext Access 11 Pages 2007
Biological profile of new apoptotic agents based on 2,4-pyrido[2,3-d]pyrimidine derivatives Fulltext Access 11 Pages 2007
Inhibition of FLT3 and PDGFR tyrosine kinase activity by bis(benzo[b]furan-2-yl)methanones Fulltext Access 11 Pages 2007
Modeling of human ghrelin receptor (hGHS-R1a) in its close state and validation by molecular docking Fulltext Access 11 Pages 2007
Influence of 6 or 8-substitution on the antiviral activity of 3-phenethylthiomethylimidazo[1,2-a]pyridine against human cytomegalovirus (HCMV) and varicella-zoster virus (VZV) Fulltext Access 11 Pages 2007
MexAB-OprM specific efflux pump inhibitors in Pseudomonas aeruginosa. Part 7: Highly soluble and in vivo active quaternary ammonium analogue D13-9001, a potential preclinical candidate Fulltext Access 11 Pages 2007
Resisting degradation by human elastase: Commonality of design features shared by ‘canonical’ plant and bacterial macrocyclic protease inhibitor scaffolds Fulltext Access 11 Pages 2007
Design, synthesis and cardioprotective effect of a new class of dual-acting agents: Phenolic tetrahydro-β-carboline RGD peptidomimetic conjugates Fulltext Access 11 Pages 2007
5′-O-Masked 2′-deoxyadenosine analogues as lead compounds for hepatitis C virus (HCV) therapeutic agents Fulltext Access 11 Pages 2007
Synthesis and evaluation of amino-threoses in d- and l-series: Are five membered ring amino-sugars more potent glycosidase inhibitors than the six membered ones? Fulltext Access 11 Pages 2007
Aminoglycoside antibiotic derivatives: Preparation and evaluation of toxicity on cochlea and vestibular tissues and antimicrobial activity Fulltext Access 11 Pages 2007
Inhibition of monoamine oxidase B by selected benzimidazole and caffeine analogues Fulltext Access 11 Pages 2007
Preparation, biological activity and endogenous occurrence of N6-benzyladenosines Fulltext Access 11 Pages 2007
A chromone analog inhibits TNF-α induced expression of cell adhesion molecules on human endothelial cells via blocking NF-κB activation Fulltext Access 11 Pages 2007
Amphiphilic polyether branched molecules to increase the circulation time of cationic particles Fulltext Access 11 Pages 2007
Free-radical-scavenging effect of carbazole derivatives on AAPH-induced hemolysis of human erythrocytes Fulltext Access 11 Pages 2007
Selective l-nitroargininylaminopyrrolidine and l-nitroargininylaminopiperidine neuronal nitric oxide synthase inhibitors Fulltext Access 11 Pages 2007
1,4-Bis(alkylamino)benzo[g]phthalazines able to form dinuclear complexes of Cu(II) which as free ligands behave as SOD inhibitors and show efficient in vitro activity against Trypanosoma cruzi Fulltext Access 11 Pages 2007
Crystal structure of the PXR–T1317 complex provides a scaffold to examine the potential for receptor antagonism Fulltext Access 11 Pages 2007
Synthesis and biological evaluation of conformationally constrained analogues of the antitubercular agent ethambutol Fulltext Access 11 Pages 2007
Damipipecolin and damituricin, novel bioactive bromopyrrole alkaloids from the Mediterranean sponge Axinella damicornis Fulltext Access 11 Pages 2007
One pot synthesis of pyrimidine and bispyrimidine derivatives and their evaluation for anti-inflammatory and analgesic activities Fulltext Access 11 Pages 2007
Synthesis, docking studies and anti-inflammatory activity of 4,5,6,7-tetrahydro-2H-indazole derivatives Fulltext Access 11 Pages 2007