Synthesis, study of 3D structures, and pharmacological activities of lipophilic nitroimidazolyl-1,4-dihydropyridines as calcium channel antagonist Fulltext Access 8 Pages 2006
QSPR models for polychlorinated biphenyls: n-Octanol/water partition coefficient Fulltext Access 8 Pages 2006
Enzymatically stable 5′ mRNA cap analogs: Synthesis and binding studies with human DcpS decapping enzyme Fulltext Access 8 Pages 2006
Binding analysis of glycyrrhetinic acid to human serum albumin: Fluorescence spectroscopy, FTIR, and molecular modeling Fulltext Access 8 Pages 2006
Synthesis and antiproliferative evaluation of certain 4-anilino-8-methoxy-2-phenylquinoline and 4-anilino-8-hydroxy-2-phenylquinoline derivatives Fulltext Access 8 Pages 2006
Quantitative structure–activity relationship of spirosuccinimide type aldose reductase inhibitors diminishing sorbitol accumulation in vivo Fulltext Access 8 Pages 2006
Interaction of arylpiperazine ligands with the hydrophobic part of the 5-HT1A receptor binding site Fulltext Access 8 Pages 2006
Synthesis and transdermal permeation-enhancing activity of ketone, amide, and alkane analogs of Transkarbam 12 Fulltext Access 8 Pages 2006
A new synthetic protocol for labeled oligonucleotides, using a chemically cleavable universal linker Fulltext Access 8 Pages 2006
Correlation of the acid-sensitivity of polyethylene glycol daunorubicin conjugates with their in vitro antiproliferative activity Fulltext Access 8 Pages 2006
Spirocyclopropyl pyrrolidines as a new series of α-l-fucosidase inhibitors Fulltext Access 8 Pages 2006
New Taxol® (paclitaxel) prodrugs designed for ADEPT and PMT strategies in cancer chemotherapy Fulltext Access 8 Pages 2006
QSAR by LFER model of HIV protease inhibitor mannitol derivatives using FA-MLR, PCRA, and PLS techniques Fulltext Access 8 Pages 2006
QSAR study of 1,4-dihydropyridine calcium channel antagonists based on gene expression programming Fulltext Access 8 Pages 2006
Synthesis and antibacterial activity of substituted flavones, 4-thioflavones and 4-iminoflavones Fulltext Access 8 Pages 2006
Antioxidant and anticancer activities of novel p-alkylaminophenols and p-acylaminophenols (aminophenol analogues) Fulltext Access 8 Pages 2006
Synthesis, receptor binding, and activation studies of N(1)-alkyl-l-histidine containing thyrotropin-releasing hormone (TRH) analogues Fulltext Access 8 Pages 2006
Unify QSAR approach to antimicrobials. Part 1: Predicting antifungal activity against different species Fulltext Access 8 Pages 2006
Synthesis and cellular studies of a carboranylchlorin for the PDT and BNCT of tumors Fulltext Access 8 Pages 2006
Safrole oxide induces apoptosis by up-regulating Fas and FasL instead of integrin β4 in A549 human lung cancer cells Fulltext Access 8 Pages 2006
2-Aminothiophene-3-carboxylates and carboxamides as adenosine A1 receptor allosteric enhancers Fulltext Access 8 Pages 2006
Solvent free microwave synthesis and evaluation of antimicrobial activity of pyrimido[4,5-b]- and pyrazolo[3,4-b]quinolines Fulltext Access 8 Pages 2006
Isolation and cholinesterase-inhibition studies of sterols from Haloxylon recurvum Fulltext Access 8 Pages 2006
Identification of potent and highly selective chiral tri-amine and tetra-amine μ opioid receptors ligands: An example of lead optimization using mixture-based libraries Fulltext Access 8 Pages 2006
QSAR analysis of some 5-amino-2-mercapto-1,3,4-thiadiazole based inhibitors of matrix metalloproteinases and bacterial collagenase Fulltext Access 8 Pages 2006
Cyclopentane-based human NK1 antagonists. Part 2: Development of potent, orally active, water-soluble derivatives Fulltext Access 8 Pages 2006
Comparative QSAR modeling of CCR5 receptor binding affinity of substituted 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas Fulltext Access 8 Pages 2006
Synthesis and structure–activity relationships of retro bis-aminopyrrolidine urea (rAPU) derived small-molecule antagonists of the melanin-concentrating hormone receptor-1 (MCH-R1). Part 1 Fulltext Access 8 Pages 2006
QSAR analysis of meclofenamic acid analogues as selective COX-2 inhibitors Fulltext Access 8 Pages 2006
Correlation of antibacterial activity of some N-[5-(2-furanyl)-2-methyl-4-oxo-4H-thieno[2,3-d]pyrimidin-3-yl]-carboxamide and 3-substituted-5-(2-furanyl)-2-methyl-3H-thieno[2,3-d]pyrimidin-4-ones with topological indices using Hansch analysis Fulltext Access 8 Pages 2006
4-Amino-2-alkyl-butyramides as small molecule CCR2 antagonists with favorable pharmacokinetic properties Fulltext Access 8 Pages 2006
QSAR study on topically acting sulfonamides incorporating GABA moieties: A molecular connectivity approach Fulltext Access 8 Pages 2006
Studies on synthesis and evaluation of quantitative structure-activity relationship of 10-methyl-6-oxo-5-arylazo-6,7-dihydro-5H-[1,3]azaphospholo[1,5-d][1,4]benzodiazepin-2-phospha-3-ethoxycarbonyl-1-phosphorus dichlorides Fulltext Access 8 Pages 2006
Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands Fulltext Access 8 Pages 2006
Characterization of high molecular weight impurities in synthetic phosphorothioate oligonucleotides Fulltext Access 8 Pages 2006
Preparation of yuanhuacine and relative daphne diterpene esters from Daphne genkwa and structure–activity relationship of potent inhibitory activity against DNA topoisomerase I Fulltext Access 8 Pages 2006
Synthesis and in vitro antibiotic activity of 16-membered 9-O-arylalkyloxime macrolides Fulltext Access 8 Pages 2006
Respiratory syncytial virus fusion inhibitors. Part 3: Water-soluble benzimidazol-2-one derivatives with antiviral activity in vivo Fulltext Access 8 Pages 2006
Cluster analysis and two-dimensional quantitative structure–activity relationship (2D-QSAR) of Pseudomonas aeruginosa deacetylase LpxC inhibitors Fulltext Access 8 Pages 2006
Aminopyridine carboxamides as c-Jun N-terminal kinase inhibitors: Targeting the gatekeeper residue and beyond Fulltext Access 8 Pages 2006
Structural characterization of novel cobalt corrinoids synthesized by enzymes of the vitamin B12 anaerobic pathway Fulltext Access 8 Pages 2006
Synthesis, antiviral, and antitumor activity of 2-substituted purine methylenecyclopropane analogues of nucleosides Fulltext Access 8 Pages 2006
3′-N-Alkylamino-3′-deoxy-ara-uridines: A new class of potential inhibitors of ribonuclease A and angiogenin Fulltext Access 8 Pages 2006
A chemoenzymatic scalable route to optically active (R)-1-(pyridin-3-yl)-2-aminoethanol, valuable moiety of β3-adrenergic receptor agonists Fulltext Access 8 Pages 2006
QSAR analysis of phenolic antioxidants using MOLMAP descriptors of local properties Fulltext Access 8 Pages 2006
Synthesis and antimicrobial activity of N-alkyl and N-aryl piperazine derivatives Fulltext Access 8 Pages 2006
Synthesis, cytotoxicity, and DNA-topoisomerase inhibitory activity of new asymmetric ureas and thioureas Fulltext Access 8 Pages 2006
Engineering non-natural inhibitor sensitivity in protein tyrosine phosphatase H1 Fulltext Access 8 Pages 2006
Inhibitory effects of coumarin and acetylene constituents from the roots of Angelica furcijuga on d-galactosamine/lipopolysaccharide-induced liver injury in mice and on nitric oxide production in lipopolysaccharide-activated mouse peritoneal macrophages Fulltext Access 8 Pages 2006
An image contrast agent selectively activated by prostate specific antigen Fulltext Access 8 Pages 2006
Synthesis and evaluation of novel enhanced gene reporter molecules: Detection of β-galactosidase activity using 19F NMR of trifluoromethylated aryl β-d-galactopyranosides Fulltext Access 8 Pages 2006
Quaternary ammonium substituted thieno[3,2-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides: Potential membrane-impermeable inhibitors of carbonic anhydrase Fulltext Access 8 Pages 2006
Synthesis of some novel pyrazolo[3,4-d]pyrimidine derivatives as potential antimicrobial agents Fulltext Access 8 Pages 2006
An evaluation of automated in silico ligand docking of amino acid ligands to Family C G-protein coupled receptors Fulltext Access 8 Pages 2006
Synthesis, in vitro pharmacology and biodistribution studies of new PD 156707-derived ETA receptor radioligands Fulltext Access 8 Pages 2006
Synthesis and testing of a triaza-cyclopenta[b]phenanthrene scaffold as a DNA binding agent Fulltext Access 8 Pages 2006
Design, synthesis, and biological evaluation of alcyopterosin A and illudalane derivatives as anticancer agents Fulltext Access 8 Pages 2006
In vitro aldose reductase inhibitory activity of 5-benzyl-2,4-thiazolidinediones Fulltext Access 8 Pages 2006
Lipase-catalyzed preparation of optically active 1′-acetoxychavicol acetates and their structure–activity relationships in apoptotic activity against human leukemia HL-60 cells Fulltext Access 8 Pages 2006
Enantiomeric N-methyl-4-piperidyl benzilates as muscarinic receptor ligands: Radioligand binding studies and docking studies to models of the three muscarinic receptors M1, M2 and M3 Fulltext Access 8 Pages 2006
New 1,3,4-thiadiazole derivatives endowed with analgesic and anti-inflammatory activities Fulltext Access 8 Pages 2006
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: Design, synthesis, and microbiological evaluation Fulltext Access 8 Pages 2006
The introduction of fluorine atoms or trifluoromethyl groups in short cationic peptides enhances their antimicrobial activity Fulltext Access 8 Pages 2006
Cytotoxic labdane alkaloids from an ascidian Lissoclinum sp.: Isolation, structure elucidation, and structure–activity relationship Fulltext Access 8 Pages 2006
Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue Fulltext Access 8 Pages 2006
Design, synthesis, and biological evaluation of substituted 2,3-dihydro-1H-cyclopenta[b]quinolin-9-ylamine related compounds as fructose-1,6-bisphosphatase inhibitors Fulltext Access 8 Pages 2006
Inhibition of protein kinase C by dequalinium analogues: Structure–activity studies on head group variations Fulltext Access 8 Pages 2006
Molecular modeling of non-covalent binding of homochiral (3S,3′S)-astaxanthin to matrix metalloproteinase-13 (MMP-13) Fulltext Access 8 Pages 2006
Synthesis, anti-inflammatory, analgesic and kinase (CDK-1, CDK-5 and GSK-3) inhibition activity evaluation of benzimidazole/benzoxazole derivatives and some Schiff’s bases Fulltext Access 8 Pages 2006
Norbornyllactone-substituted xanthines as adenosine A1 receptor antagonists Fulltext Access 8 Pages 2006
Synthesis of imidazoline and imidazo[2,1-c][1,2,4]triazole aryl derivatives containing the methylthio group as possible antibacterial agents Fulltext Access 8 Pages 2006
Artepillin C isoprenomics: Design and synthesis of artepillin C isoprene analogues as lipid peroxidation inhibitor having low mitochondrial toxicity Fulltext Access 8 Pages 2006
Exploration of orally available calpain inhibitors. Part 3: Dipeptidyl α-ketoamide derivatives containing pyridine moiety Fulltext Access 8 Pages 2006
Synthesis and pharmacological activities of xanthone derivatives as α-glucosidase inhibitors Fulltext Access 8 Pages 2006
Novel benzofuran inhibitors of human mitogen-activated protein kinase phosphatase-1 Fulltext Access 8 Pages 2006
One novel quinoxaline derivative as a potent human cyclophilin A inhibitor shows highly inhibitory activity against mouse spleen cell proliferation Fulltext Access 8 Pages 2006
Anticancer activities of some newly synthesized pyridine, pyrane, and pyrimidine derivatives Fulltext Access 8 Pages 2006
Trypanocidal agents with low cytotoxicity to mammalian cell line: A comparison of the theoretical and biological features of lapachone derivatives Fulltext Access 8 Pages 2006
On-bead combinatorial techniques for the identification of selective aldose reductase inhibitors Fulltext Access 8 Pages 2006
Cysteine based novel noncompetitive inhibitors of urease(s)—Distinctive inhibition susceptibility of microbial and plant ureases Fulltext Access 8 Pages 2006
Synthesis of benzenepropanamine analogues as non-detergent spermicides with antitrichomonas and anticandida activities Fulltext Access 8 Pages 2006
Loss of antagonistic activity of tamoxifen by replacement of one N-methyl of its side chain by fluorinated residues Fulltext Access 8 Pages 2006
Novel A-ring homodimeric C-3-carbamate analogues of 1α,25-dihydroxyvitamin D3: Synthesis and preliminary biological evaluation Fulltext Access 8 Pages 2006
Synthesis and biological activity of Schiff and Mannich bases bearing 2,4-dichloro-5-fluorophenyl moiety Fulltext Access 8 Pages 2006
Phenylethanoid oligoglycosides and acylated oligosugars with vasorelaxant activity from Cistanche tubulosa Fulltext Access 8 Pages 2006
Hydrazones of 2-aryl-quinoline-4-carboxylic acid hydrazides: Synthesis and preliminary evaluation as antimicrobial agents Fulltext Access 8 Pages 2006
Synthesis of 4-aryl-3,4-dihydropyrimidin-2(1H)-thione derivatives as potential calcium channel blockers Fulltext Access 8 Pages 2006
Synthesis and evaluation of a new series of substituted acyl(thio)urea and thiadiazolo [2,3-a] pyrimidine derivatives as potent inhibitors of influenza virus neuraminidase Fulltext Access 8 Pages 2006
An efficient synthesis and biological activity of substituted p-benzoquinones Fulltext Access 8 Pages 2006
Dual PPAR-α and -γ activators derived from novel benzoxazinone containing thiazolidinediones having antidiabetic and hypolipidemic potential Fulltext Access 8 Pages 2006