Design, synthesis and biological evaluation of novel riccardiphenol analogs Fulltext Access 8 Pages 2005
Structure–activity relationship for aryl and heteroaryl boronic acid inhibitors of hormone-sensitive lipase Fulltext Access 8 Pages 2005
Synthesis and antiamoebic activities of 1-N-substituted cyclised pyrazoline analogues of thiosemicarbazones Fulltext Access 8 Pages 2005
Heterocyclic inhibitors of dihydrodipicolinate synthase are not competitive Fulltext Access 8 Pages 2005
Design, synthesis, antibacterial and QSAR studies of benzimidazole and imidazole chloroaryloxyalkyl derivatives Fulltext Access 8 Pages 2005
Tetrazolyl isoxazole amino acids as ionotropic glutamate receptor antagonists: Synthesis, modelling and molecular pharmacology Fulltext Access 8 Pages 2005
Novel A-ring analogs of the hormone 1α,25-dihydroxyvitamin D3: synthesis and preliminary biological evaluation Fulltext Access 8 Pages 2005
1,2,4-Triazino-[5,6b]indole derivatives: effects of the trifluoromethyl group on in vitro antimalarial activity Fulltext Access 8 Pages 2005
Docking simulation with a purine nucleoside specific homology model of deoxycytidine kinase, a target enzyme for anticancer and antiviral therapy Fulltext Access 8 Pages 2005
Towards new boron carriers for boron neutron capture therapy: metallacarboranes and their nucleoside conjugates Fulltext Access 8 Pages 2005
Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lung cancer cells Fulltext Access 8 Pages 2005
Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues Fulltext Access 8 Pages 2005
The novel GABA adamantane derivative (AdGABA): design, synthesis, and activity relationship with gabapentin Fulltext Access 8 Pages 2005
An estradiol-conjugate for radiolabelling with 177Lu: an attempt to prepare a radiotherapeutic agent Fulltext Access 8 Pages 2005
Biotin-labeled abscisic acid as a probe for investigating abscisic acid binding sites on plasma membranes of barley aleurone protoplasts Fulltext Access 8 Pages 2005
Biocatalysed synthesis of β-O-glucosides from 9-fluorenon-2-carbohydroxyesters. Part 3: IFN-inducing and anti-HSV-2 properties Fulltext Access 8 Pages 2005
Linear indices of the 'macromolecular graph's nucleotides adjacency matrix' as a promising approach for bioinformatics studies. Part 1: Prediction of paromomycin's affinity constant with HIV-1 Ψ-RNA packaging region Fulltext Access 8 Pages 2005
Synthesis of phthalates of betulinic acid and betulin with cytotoxic activity Fulltext Access 8 Pages 2005
1,4-Dihydropyridine derivatives as calcium channel modulators: the role of 3-methoxy-flavone moiety Fulltext Access 8 Pages 2005
Comparative molecular similarity indices analysis (CoMSIA) studies of 1,2-naphthoquinone derivatives as PTP1B inhibitors Fulltext Access 8 Pages 2005
The inclusion complexes of hesperetin and its 7-rhamnoglucoside with (2-hydroxypropyl)-β-cyclodextrin Fulltext Access 9 Pages 2005
Trifluoromethyl group as a pharmacophore: Effect of replacing a CF3 group on binding and agonist activity of a glucocorticoid receptor ligand Fulltext Access 9 Pages 2005
Determination of methyl and ethyl esters of methanesulfonic, benzenesulfonic and p-toluenesulfonic acids in active pharmaceutical ingredients by solid-phase microextraction (SPME) coupled to GC/SIM-MS Fulltext Access 9 Pages 2005
Development and validation of a sensitive GC-MS method for the determination of trace levels of an alkylating reagent in a β-lactam active pharmaceutical ingredient Fulltext Access 9 Pages 2005
Development and validation of a dissolution test for a once-a-day combination tablet of immediate-release cetirizine dihydrochloride and extended-release pseudoephedrine hydrochloride Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of 3,4-diphenyl-1,2,5-oxadiazole-2-oxides and 3,4-diphenyl-1,2,5-oxadiazoles as potential hybrid COX-2 inhibitor/nitric oxide donor agents Fulltext Access 9 Pages 2005
Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway Fulltext Access 9 Pages 2005
Horseradish peroxidase-mediated aerobic and anaerobic oxidations of 3-alkylindoles Fulltext Access 9 Pages 2005
Mutation of surface cysteine 374 to alanine in monoamine oxidase A alters substrate turnover and inactivation by cyclopropylamines Fulltext Access 9 Pages 2005
Simultaneous determination of rosuvastatin and fenofibric acid in human plasma by LC-MS/MS with electrospray ionization: Assay development, validation and application to a clinical study Fulltext Access 9 Pages 2005
A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis Fulltext Access 9 Pages 2005
A validated stability-indicating HPLC with photodiode array detector (PDA) method for the stress tests of Monascus purpureus-fermented rice, red yeast rice Fulltext Access 9 Pages 2005
Stability indicating RP-HPLC method for simultaneous determination of amlodipine and benazepril hydrochloride from their combination drug product Fulltext Access 9 Pages 2005
Chemically modified carbon paste electrode for the potentiometric flow injection analysis of piribedil in pharmaceutical preparation and urine Fulltext Access 9 Pages 2005
Theoretical quantitative structure–activity relationships of flavone ligands interacting with cytochrome P450 1A1 and 1A2 isozymes Fulltext Access 9 Pages 2005
Synthesis, conformational analysis, and biological activity of new analogues of thiazole-4-carboxamide adenine dinucleotide (TAD) as IMP dehydrogenase inhibitors Fulltext Access 9 Pages 2005
Modeling Km values using electrotopological state: Substrates for cytochrome P450 3A4-mediated metabolism Fulltext Access 9 Pages 2005
Structure–activity study of epi-gallocatechin gallate (EGCG) analogs as proteasome inhibitors Fulltext Access 9 Pages 2005
Inhibitory effects of 2-substituted-1-naphthol derivatives on cyclooxygenase I and II Fulltext Access 9 Pages 2005
3,5-Bicyclic aryl piperidines: A novel class of α4β2 neuronal nicotinic receptor partial agonists for smoking cessation Fulltext Access 9 Pages 2005
LC-UV method development and validation for the investigational anticancer agent imexon and identification of its degradation products Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of 2-aminothiazoles and their amide derivatives on human adenosine receptors. Lack of effect of 2-aminothiazoles as allosteric enhancers Fulltext Access 9 Pages 2005
Synthesis and biological activity of fluoroquinolone-pyrrolo[2,1-c][1,4]benzodiazepine conjugates Fulltext Access 9 Pages 2005
Insecticidal anthranilic diamides: A new class of potent ryanodine receptor activators Fulltext Access 9 Pages 2005
Chiral cyclopalladated complexes derived from N,N-dimethyl-1-phenethylamine with bridging bis(diphenylphosphine)ferrocene ligand as inhibitors of the cathepsin B activity and as antitumoral agents Fulltext Access 9 Pages 2005
Synthesis, properties, and photodynamic inactivation of Escherichia coli using a cationic and a noncharged Zn(II) pyridyloxyphthalocyanine derivatives Fulltext Access 9 Pages 2005
[11C]Glycylsarcosine: synthesis and in vivo evaluation as a PET tracer of PepT2 transporter function in kidney of PepT2 null and wild-type mice Fulltext Access 9 Pages 2005
Design and synthesis of labeled analogs of PhTX-56, a potent and selective AMPA receptor antagonist Fulltext Access 9 Pages 2005
Influence of esterification and modification of A-ring in a group of lupane acids on their cytotoxicity Fulltext Access 9 Pages 2005
Semisynthesis and biological activity of aminoacyl triesters of squamocin, an annonaceous acetogenin Fulltext Access 9 Pages 2005
Synthesis, in vitro, and in vivo characterization of an integrin αvβ3-targeted molecular probe for optical imaging of tumor Fulltext Access 9 Pages 2005
Synthesis and cytotoxic activity of N-[(alkylamino)alkyl]carboxamide derivatives of 7-oxo-7H-benz[de]anthracene, 7-oxo-7H-naphtho[1,2,3-de]quinoline, and 7-oxo-7H-benzo[e]perimidine Fulltext Access 9 Pages 2005
Design, syntheses, and biological evaluations of squamostolide and its related analogs Fulltext Access 9 Pages 2005
Synthesis and evaluation of antioxidative properties of a series of organoselenium compounds Fulltext Access 9 Pages 2005
Synthesis, anti-inflammatory and analgesic activities evaluation of some mono, bi and tricyclic pyrimidine derivatives Fulltext Access 9 Pages 2005
Antiviral cyclic d,l-α-peptides: Targeting a general biochemical pathway in virus infections Fulltext Access 9 Pages 2005
Synthesis and antileishmanial activities of 4,5-di-substituted acridines as compared to their 4-mono-substituted homologues Fulltext Access 9 Pages 2005
8-O-Azeloyl-14-benzoylaconine: A new alkaloid from the roots of Aconitum karacolicum Rapcs and its antiproliferative activities Fulltext Access 9 Pages 2005
Synthesis, antiproliferative, and antiplatelet activities of oxime- and methyloxime-containing flavone and isoflavone derivatives Fulltext Access 9 Pages 2005
Chalcogenoxanthylium photosensitizers for the photodynamic purging of blood-borne viral and bacterial pathogens Fulltext Access 9 Pages 2005
Dicationic near-linear biphenyl benzimidazole derivatives as DNA-targeted antiprotozoal agents Fulltext Access 9 Pages 2005
Synthesis and in vitro anti-mycobacterial activity of 5-substituted pyrimidine nucleosides Fulltext Access 9 Pages 2005
Synthesis, antimalarial, antileishmanial, and antimicrobial activities of some 8-quinolinamine analogues Fulltext Access 9 Pages 2005
Fancy bioisosteres: Synthesis, SAR, and pharmacological investigations of novel nonaromatic dopamine D3 receptor ligands Fulltext Access 9 Pages 2005
Phthalazine PDE IV inhibitors: Conformational study of some 6-methoxy-1,4-disubstituted derivatives Fulltext Access 9 Pages 2005
Porphyrin substituted phosphoramidites: new building blocks for porphyrin–oligonucleotide syntheses Fulltext Access 9 Pages 2005
Design, synthesis, and biological testing of thiosalicylamides as a novel class of calcium channel blockers Fulltext Access 9 Pages 2005
Design and synthesis of glycosidase inhibitor 5-amino-1,2,3,4-cyclohexanetetrol derivatives from (−)-vibo-quercitol Fulltext Access 9 Pages 2005
Synthesis of acridinyl-thiazolino derivatives and their evaluation for anti-inflammatory, analgesic and kinase inhibition activities Fulltext Access 9 Pages 2005
3D-QSAR study of bis-azaaromatic quaternary ammonium analogs at the blood-brain barrier choline transporter Fulltext Access 9 Pages 2005
Synthesis of a C-terminally biotinylated macrocyclic peptide mimetic exhibiting high Grb2 SH2 domain-binding affinity Fulltext Access 9 Pages 2005
Radical scavenging activity of dicaffeoyloxycyclohexanes: Contribution of an intramolecular interaction of two caffeoyl residues Fulltext Access 9 Pages 2005
A quantitative structure-activity relationship study on some series of anthranilic acid-based matrix metalloproteinase inhibitors Fulltext Access 9 Pages 2005
Hypocholesterolemic effects of phenolic-rich extracts of Chemlali olive cultivar in rats fed a cholesterol-rich diet Fulltext Access 9 Pages 2005
Bridge-linked bis-quaternary ammonium anti-microbial agents: relationship between cytotoxicity and anti-bacterial activity of 5,5′-[2,2′-(tetramethylenedicarbonyldioxy)-diethyl]bis(3-alkyl-4-methylthiazonium iodide)s Fulltext Access 9 Pages 2005
Synthesis and antiprotozoan evaluation of new alkyl-linked bis(2-thioxo-[1,3,5]thiadiazinan-3-yl) carboxylic acids Fulltext Access 9 Pages 2005
Quantitative structure–activity relationship to predict differential inhibition of aldose reductase by flavonoid compounds Fulltext Access 9 Pages 2005
Anti-cancer ProTides: tuning the activity of BVDU phosphoramidates related to thymectacin Fulltext Access 9 Pages 2005
Synthesis and biological evaluation of novel 6-nitro-5-substituted aminoquinolines as local anesthetic and anti-arrhythmic agents: molecular modeling study Fulltext Access 9 Pages 2005
3D-QSAR studies on c-Src kinase inhibitors and docking analyses of a potent dual kinase inhibitor of c-Src and c-Abl kinases Fulltext Access 9 Pages 2005
Synthesis and C-11 labeling of three potent norepinephrine transporter selective ligands ((R)-nisoxetine, lortalamine, and oxaprotiline) for comparative PET studies in baboons Fulltext Access 9 Pages 2005
Oligonucleotides containing 2′-O-[2-(2,3-dihydroxypropyl)amino-2-oxoethyl]uridine as suitable precursors of 2′-aldehyde oligonucleotides for chemoselective ligation Fulltext Access 9 Pages 2005
Design and synthesis of low molecular weight compounds with complement inhibition activity Fulltext Access 9 Pages 2005
Design, synthesis, and biological evaluation of novel naphthoquinone derivatives with CDC25 phosphatase inhibitory activity Fulltext Access 9 Pages 2005
Synthesis of novel 5-aryl-2-thio-1,3,4-oxadiazoles and the study of their structure–anti-mycobacterial activities Fulltext Access 9 Pages 2005