Physical stability of the amorphous state of loperamide and two fragment molecules in solid dispersions with the polymers PVP-K30 and PVP-VA64 Fulltext Access 8 Pages 2005
Preparation of chitosan beads by simultaneous cross-linking/insolubilisation in basic pH Fulltext Access 8 Pages 2005
Brain penetration of synthetic adenosine A1 receptor agonists in situ: role of the rENT1 nucleoside transporter and binding to blood constituents Fulltext Access 8 Pages 2005
Contribution of academic research to discovery and development of medicines: current status and future opportunities Fulltext Access 8 Pages 2005
Clinical study of solid dispersions of itraconazole prepared by hot-stage extrusion Fulltext Access 8 Pages 2005
Evaluation of a chylomicron flow blocking approach to investigate the intestinal lymphatic transport of lipophilic drugs Fulltext Access 8 Pages 2005
Influence of flow rate on the disposition of levofloxacin and netilmicin in the isolated rat lung Fulltext Access 8 Pages 2005
Microcalorimetric studies of the effects on the interactions of human recombinant interferon-α2a Fulltext Access 8 Pages 2005
Bioreversible quaternary N-acyloxymethyl derivatives of the tertiary amines bupivacaine and lidocaine-synthesis, aqueous solubility and stability in buffer, human plasma and simulated intestinal fluid Fulltext Access 8 Pages 2005
A simple method for differentiation of monoisotopic drug metabolites with hydrogen-deuterium exchange liquid chromatography/electrospray mass spectrometry Fulltext Access 8 Pages 2005
A solid-state NMR study of molecular mobility and phase separation in co-spray-dried protein-sugar particles Fulltext Access 8 Pages 2005
Characterization of the 13-cis-retinoic acid/cyclodextrin inclusion complexes by phase solubility, photostability, physicochemical and computational analysis Fulltext Access 8 Pages 2005
Polyelectrolyte complex formation and stability when mixing polyanions and polycations in salted media: A model study related to the case of body fluids Fulltext Access 8 Pages 2005
Synthesis and antiamoebic activity of 3,7-dimethyl-pyrazolo[3,4-e][1,2,4] triazin-4-yl thiosemicarbazide derivatives Fulltext Access 8 Pages 2005
SDS-aided immobilization and controlled release of camptothecin from agarose hydrogel Fulltext Access 8 Pages 2005
Effect of experimental pH on the in vitro permeability in intact rabbit intestines and Caco-2 monolayer Fulltext Access 8 Pages 2005
Can protonated β-blockers interact with biomembranes stronger than neutral isolipophilic compounds? Fulltext Access 8 Pages 2005
Geometric mean ratio-dependent scaled bioequivalence limits with leveling-off properties Fulltext Access 8 Pages 2005
Development and optimization of a rapid HPLC method for analysis of ricobendazole and albendazole sulfone in sheep plasma Fulltext Access 8 Pages 2005
Simultaneous determination of loratadine and pseudoephedrine sulfate in human plasma by liquid chromatography-electrospray mass spectrometry for pharmacokinetic studies Fulltext Access 8 Pages 2005
Progress toward automated metabolic profiling of human serum: Comparison of CPMG and gradient-filtered NMR analytical methods Fulltext Access 8 Pages 2005
A validated spectrofluorimetric method for determination of some psychoactive drugs Fulltext Access 8 Pages 2005
PVC membrane ion-selective electrodes for the determination of Hyoscyamine in pure solution and in pharmaceutical preparations under batch and flow modes Fulltext Access 8 Pages 2005
A new validated method for the simultaneous determination of benzocaine, propylparaben and benzyl alcohol in a bioadhesive gel by HPLC Fulltext Access 8 Pages 2005
Simultaneous determination of Z-3-[(2,4-dimethylpyrrol-5-yl)methylidenyl]-2-indolinone (SU5416) and its interconvertible geometric isomer (SU5886) in rat plasma by LC/MS/MS Fulltext Access 8 Pages 2005
Improving the solubility of ampelopsin by solid dispersions and inclusion complexes Fulltext Access 8 Pages 2005
Evaluation of chemical and diastereoisomeric stability of S-adenosylmethionine in aqueous solution by capillary electrophoresis Fulltext Access 8 Pages 2005
Simultaneous determination of phenytoin, barbital and caffeine in pharmaceuticals by absorption (zero-order) UV spectra and first-order derivative spectra-multivariate calibration methods Fulltext Access 8 Pages 2005
A simple and sensitive LC/MS/MS assay for 7-ethyl-10-hydroxycamptothecin (SN-38) in mouse plasma and tissues: application to pharmacokinetic study of liposome entrapped SN-38 (LE-SN38) Fulltext Access 8 Pages 2005
Hyphenation of capillary high-performance liquid chromatography to microcoil magnetic resonance spectroscopy-determination of various carotenoids in a small-sized spinach sample Fulltext Access 8 Pages 2005
In vitro metabolism of a new oxazolidinedione hypoglycemic agent utilizing liver microsomes and recombinant human cytochrome P450 enzymes Fulltext Access 8 Pages 2005
Validation of a semi-automated human hepatocyte assay for the determination and prediction of intrinsic clearance in discovery Fulltext Access 8 Pages 2005
Rapid quantification of nebivolol in human plasma by liquid chromatography coupled with electrospray ionization tandem mass spectrometry Fulltext Access 8 Pages 2005
Development and validation of a radioreceptor assay for the determination of morphine and its active metabolites in serum Fulltext Access 8 Pages 2005
Development and validation of an LC-UV method for the quantification and purity determination of the novel anticancer agent C1311 and its pharmaceutical dosage form Fulltext Access 8 Pages 2005
A new approach in the prediction of the dissolution behavior of suspended particles by means of their particle size distribution Fulltext Access 8 Pages 2005
Mechanistic explanation to the catalysis by pyrazinamide and ethambutol of reaction between rifampicin and isoniazid in anti-TB FDCs Fulltext Access 8 Pages 2005
Capillary electrophoresis analysis of hydrogen peroxide induced apoptosis in PC12 cells Fulltext Access 8 Pages 2005
Electrochemical study of imipenem's primary metabolite at the mercury electrode Fulltext Access 8 Pages 2005
Hydrophilic interaction liquid chromatography-APCI-mass spectrometry determination of 5-fluorouracil in plasma and tissues Fulltext Access 8 Pages 2005
Determination of potato carboxypeptidase inhibitor in African Green Monkey plasma using 96-well SPE and LC-MS/MS Fulltext Access 8 Pages 2005
Development of a gas chromatography method for the determination of isotretinoin and its degradation products in pharmaceuticals Fulltext Access 8 Pages 2005
Analysis of the acid-base reaction between solid indomethacin and sodium bicarbonate using infrared spectroscopy, X-ray powder diffraction, and solid-state nuclear magnetic resonance spectroscopy Fulltext Access 8 Pages 2005
Electrochemical genosensing of the interaction between the potential chemotherapeutic agent, cis-bis(3-aminoflavone)dichloroplatinum(II) and DNA in comparison with cis-DDP Fulltext Access 8 Pages 2005
Enantioselective capillary electrophoretic separation of tryptophane- and tyrosine-methylesters in a dual system with a tetra-oxadiaza-crown-ether derivative and a cyclodextrin Fulltext Access 8 Pages 2005
In vitro versus canine data for predicting input profiles of isosorbide-5-mononitrate from oral extended release products on a confidence interval basis Fulltext Access 8 Pages 2005
Simple Strategies for Reducing Sample Loads in In Vitro Metabolic Stability High-Throughput Screening Experiments: A Comparison between Traditional, Two-Time-Point and Pooled Sample Analyses Fulltext Access 8 Pages 2005
Low-dose Tadenan protects the rabbit bladder from bilateral ischemia/reperfusion-induced contractile dysfunction Fulltext Access 8 Pages 2005
Aqueous extract of Anoectochilus formosanus attenuate hepatic fibrosis induced by carbon tetrachloride in rats Fulltext Access 8 Pages 2005
A randomized trial of Korodin® Herz-Kreislauf-Tropfen as add-on treatment in older patients with orthostatic hypotension Fulltext Access 8 Pages 2005
Contribution of ROCK in Contraction of Trabecular Meshwork: Proposed Mechanism for Regulating Aqueous Outflow in Monkey and Human Eyes Fulltext Access 8 Pages 2005
Oral heparin delivery: Design and in vivo evaluation of a stomach-targeted mucoadhesive delivery system Fulltext Access 8 Pages 2005
Preparation of polymeric nanocapsules containing octyl methoxycinnamate by the emulsification-diffusion technique: Penetration across the stratum corneum Fulltext Access 8 Pages 2005
Erosion of microbicide formulation coating layers: Effects of contact and shearing with vaginal fluid or semen Fulltext Access 8 Pages 2005
Influence of macromolecular crowding upon the stability and state of association of proteins: Predictions and observations Fulltext Access 8 Pages 2005
Role of Organic Anion Transporting Polypeptide 2 in Pharmacokinetics of Digoxin and β-Methyldigoxin in Rats Fulltext Access 8 Pages 2005
Application of Ultrasonic Shear Rheometer to Characterize Rheological Properties of High Protein Concentration Solutions at Microliter Volume Fulltext Access 8 Pages 2005
Hepatobiliary Disposition of Liposomal Amphotericin B in the Isolated Perfused Rat Liver Fulltext Access 8 Pages 2005
In vitro decreases of the fibrinolytic potential of cultured human fibrosarcoma cell line, HT1080, by Nigella sativa oil Fulltext Access 8 Pages 2005
Biopharmaceutical Considerations on Antihistamine Effects of Topically Administered Emedastine Fulltext Access 8 Pages 2005
Structures from lysine-based dendrons and dendrimers: monolayers, dendriplexes, dendrisomes, nanoparticles and micellar aggregates Fulltext Access 8 Pages 2005
Hexakis (3,6-anhydro) tetrakis (2A,B,D,E-O-butyl) cyclomalto hexaose as a promising biological cation cryptant: complexation and NMR study of interaction with membranes Fulltext Access 8 Pages 2005
Versatility of three techniques for preparing ibuprofen-loaded methacrylic acid copolymer nanoparticles of controlled sizes Fulltext Access 8 Pages 2005
Evaluation of statistical design/modeling for prediction of the effect of amino acids on agitation-induced aggregation of human growth hormone and human insulin Fulltext Access 8 Pages 2005
Cation complexing 2-O-alkylated, 3,6-anhydro-α-cyclodextrins: the side-chain length governs physicochemical properties and practical applications Fulltext Access 8 Pages 2005
Study on supramolecular complexing ability vis-à-vis estimation of pKa of substituted sulfonamides: Dominating role of Balaban index (J) Fulltext Access 8 Pages 2005
Comparison of different heterocyclic scaffolds as substrate analog PDE5 inhibitors Fulltext Access 8 Pages 2005
Synthesis and in vitro cytotoxicity of novel hydrophilic chiral 2-alkoxy-1,4-butanediamine platinum (II) complexes Fulltext Access 8 Pages 2005
Analysis of structure–activity relationships for the ‘B-region’ of N-(4-t-butylbenzyl)-N′-[4-(methylsulfonylamino)benzyl]-thiourea analogues as TRPV1 antagonists Fulltext Access 8 Pages 2005
Saturated free fatty acid, palmitic acid, induces apoptosis in fetal hepatocytes in culture Fulltext Access 8 Pages 2005
A high performance liquid chromatography method for the simultaneous determination of arctiin, chlorogenic acid and glycyrrhizin in a Chinese proprietary medicine Fulltext Access 8 Pages 2005
Simultaneous determination of HIV-protease inhibitors lamivudine and zidovudine in pharmaceutical formulations by micellar electrokinetic chromatography Fulltext Access 8 Pages 2005
HPLC determination of salinomycin and related compounds in fermentation media of Streptomyces albus and premixes Fulltext Access 8 Pages 2005
Electrochemical characteristics of zafirlukast and its determination in pharmaceutical formulations by voltammetric methods Fulltext Access 8 Pages 2005
Evaluation of the stability of chlortetracycline in granular premixes by monitoring its conversion into degradation products Fulltext Access 8 Pages 2005
Simultaneous quantification of different cyclodextrins and Gantrez by HPLC with evaporative light scattering detection Fulltext Access 8 Pages 2005
Simultaneous determination of 10 major flavonoids in Dalbergia odorifera by high performance liquid chromatography Fulltext Access 8 Pages 2005
Assessment of the antioxidant activities of Brazilian extracts of propolis alone and in topical pharmaceutical formulations Fulltext Access 8 Pages 2005
Role of mast cells in hepatic remodeling during cholestasis and its resolution: relevance to regulation of apoptosis Fulltext Access 8 Pages 2005
Decrease of the surface fraction of surfactant proteins containing Clara cells and type II pneumocytes in a rat asthma model Fulltext Access 8 Pages 2005
Effect of Aronia melanocarpa fruit juice on indomethacin-induced gastric mucosal damage and oxidative stress in rats Fulltext Access 8 Pages 2005
Changes in histology and expression of cytokines and chemokines in the rat lung following exposure to ovalbumin Fulltext Access 8 Pages 2005
The detection of genotoxic activity and the quantitative and qualitative assessment of the consequences of exposures Fulltext Access 8 Pages 2005
Effects of anti-glaucoma drugs timolol and GLC756, a novel mixed dopamine D2 receptor agonist and D1 receptor antagonist, on endotoxin-induced-uveitis and -arthritis in rats Fulltext Access 8 Pages 2005
Inhibitory effects of Cnidium officinale Makino and Tabanus fulvus Meigan on the high glucose-induced proliferation of glomerular mesangial cells Fulltext Access 8 Pages 2005
A randomized, double-blind, placebo-controlled, clinical dose-response trial of an extract of Baptisia, Echinacea and Thuja for the treatment of patients with common cold Fulltext Access 8 Pages 2005
Efficacy of a Comfrey root extract ointment in comparison to a Diclo-fenac gel in the treatment of ankle distortions: Results of an observer-blind, randomized, multicenter study Fulltext Access 8 Pages 2005
Antibacterial activity of Turkish propolis and its qualitative and quantitative chemical composition Fulltext Access 8 Pages 2005
Antifungal constituents of Northern prickly ash, Zanthoxylum americanum Mill. Fulltext Access 8 Pages 2005
Berberine inhibits arylamine N-acetyltransferase activity and gene expression in mouse leukemia L 1210 cells Fulltext Access 8 Pages 2005
Inhibition of the myotoxic activity of Bothrops jararacussu venom and its two major myotoxins, BthTX-I and BthTX-II, by the aqueous extract of Tabernaemontana catharinensis A. DC. (Apocynaceae) Fulltext Access 8 Pages 2005