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Daneshyari Pharmacology Journas Latest Articles

Pharmacology Research Articles

Profiling the kinome for drug discovery
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Lipid peroxidation associated cardiolipin loss and membrane depolarization in rat brain mitochondria
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Nitric oxide-evoked glutamate release and cGMP production in cerebellar slices: Control by presynaptic 5-HT1D receptors
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Fragment 31–35 of β-amyloid peptide induces neurodegeneration in rat cerebellar granule cells via bax gene expression and caspase-3 activation: A crucial role for the redox state of methionine-35 residue
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Components of the protein quality control system are expressed in a strain-dependent manner in the mouse hippocampus
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Complementary molecular imaging technologies: High resolution SPECT, PET and MRI
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Potential and limitations of genetic manipulation in animals
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Genotyping technologies for all
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Proteomic approaches in drug discovery
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Proteomic analysis of GPI-anchored membrane proteins
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Two-hybrid and its recent adaptations
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Recent development of RNAi in drug target discovery and validation
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Progress in combinatorial biosynthesis for drug discovery
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Levels of G-protein αq/11 subunits and of phospholipase C-β(1–4), -γ, and -δ1 isoforms in postmortem human brain caudate and cortical membranes: Potential functional implications
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Model systems for neurofibroma and malignant peripheral nerve sheath tumor
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Nervous system cancer models: Medulloblastoma
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Surgical models of hypertrophy and heart failure: Myocardial infarction and transverse aortic constriction
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Disease models of acute bacterial meningitis
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There and back again: Autoimmune Polyendocrinopathy Syndrome Type I and the Aire knockout mouse
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Genetic deafness and gene therapy approaches for treatment
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Retinoids and pulmonary alveolar regeneration: Rationale and therapeutic challenges
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Mutations in the sodium channel Nav1.7 underlie inherited erythromelalgia
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Shared mechanisms between chronic pain and neurodegenerative disease
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Medullary control of nociceptive transmission: Reciprocal dual communication with the spinal cord
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The accessory gene regulator (agr) in methicillin-resistant Staphylococcus aureus: Role in virulence and reduced susceptibility to glycopeptide antibiotics
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The redox switch/redox coupling hypothesis
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Principaux implants utilisés en urologie
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Firing of 5-HT neurones in the dorsal and median raphe nucleus in vitro shows differential α1-adrenoceptor and 5-HT1A receptor modulation
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Depletion of reduced glutathione precedes inactivation of mitochondrial enzymes following limbic status epilepticus in the rat hippocampus
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Increased brain levels of 4-hydroxy-2-nonenal glutathione conjugates in severe Alzheimer's disease
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Differential co-expression of AMPA receptor subunits in substance P receptor-containing neurons of basal forebrain regions of C57/BL mice
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Clozapine but not haloperidol suppresses the changes in the levels of neuropeptides in MK-801-treated rat brain regions
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5-S-Cysteinyl-dopamine effect on the human dopaminergic neuroblastoma cell line SH-SY5Y
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Maturation-dependent reduced responsiveness of intracellular free Ca2+ ions to repeated stimulation by N-methyl-d-aspartate in cultured rat cortical neurons
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Structural determinants of phosphodiesterase 6 response on binding catalytic site inhibitors
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Nitric oxide-evoked cGMP production in Purkinje cells in rat cerebellum: An immunocytochemical and pharmacological study
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Aspartate aminotransferase in synaptic and nonsynaptic mitochondria: Differential effect of compounds that influence transient hetero-enzyme complex (metabolon) formation
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A dominant-negative variant of SNAP-23 decreases the cell surface expression of the neuronal glutamate transporter EAAC1 by slowing constitutive delivery
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Mechanisms and inhibition of HIV integration
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Neonatal administration of N-acetyl-l-aspartyl-l-glutamate induces early neurodegeneration in hippocampus and alters behaviour in young adult rats
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The effects of manganese on glutamate, dopamine and γ-aminobutyric acid regulation
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Effects of chronic ethanol administration on the activities and relative synthetic rates of myelin and synaptosomal plasma membrane-associated sialidase in the rat brain
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Exercise-induced changes in cardiac gene expression and its relation to spatial maze performance
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Nitric oxide alters arachidonic acid turnover in brain cortex synaptoneurosomes
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Human apoB overexpression and a high-cholesterol diet differently modify the brain APP metabolism in the transgenic mouse model of atherosclerosis
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Rotenone induces cell death in primary dopaminergic culture by increasing ROS production and inhibiting mitochondrial respiration
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Modulation of NMDA receptors by AKT kinase
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The magnetism responsive gene Ntan1 in mouse brain
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5-HT uptake blockade prevents the increasing effect of KATP channel blockers on electrically evoked [3H]-5-HT release in rat and mouse neocortical slices
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Tetrahydrobiopterin causes mitochondrial dysfunction in dopaminergic cells: Implications for Parkinson's disease
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Localization of touch versus heat pain in the human hand: A dissociative effect of temporal parameters on discriminative capacity and decision strategy
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Cancer-related bone pain is attenuated by a systemically available δ-opioid receptor agonist
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Predictive factors for 1-year and 5-year outcome for disability in a working population of patients with low back pain treated in primary care
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Involvement of cholecystokinin in peripheral nociceptive sensitization during diabetes in rats as revealed by the formalin response
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Effect of chronic nonmalignant pain on highway driving performance
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Long-term alteration of pain sensitivity in school-aged children with early pain experiences
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The influence of communication goals and physical demands on different dimensions of pain behavior
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Differential association of general and health self-efficacy with disability, health-related quality of life and psychological distress from musculoskeletal pain in a cross-sectional general adult population survey
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Developing patient-reported outcome measures for pain clinical trials: IMMPACT recommendations
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Peripheral inflammation modifies the effect of intrathecal IL-1β on spinal PGE2 production mainly through cyclooxygenase-2 activity. A spinal microdialysis study in freely moving rats
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Functional assessment of pediatric pain patients: Psychometric properties of the Functional Disability Inventory
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Pain related recall predicts future pain report
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Therapeutic efficacy of prosaposin-derived peptide on different models of allodynia
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Oxytocin and electrical stimulation of the paraventricular hypothalamic nucleus produce antinociceptive effects that are reversed by an oxytocin antagonist
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Severity of mucosal inflammation as a predictor for alterations of visceral sensory function in a rat model
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Vasoactive intestinal peptide (VIP) is a modulator of joint pain in a rat model of osteoarthritis
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Psychological “resilience” and its correlates in chronic pain: Findings from a national community sample
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Involvement of the TTX-resistant sodium channel Nav 1.8 in inflammatory and neuropathic, but not post-operative, pain states
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Continued disability and pain after lumbar disc surgery: The role of cognitive-behavioral factors
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Catastrophic thinking and heightened perception of pain in others
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Attenuation of capsaicin-evoked mechanical allodynia by peripheral neuropeptide Y Y1 receptors
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A twin study of posttraumatic stress disorder symptoms and chronic widespread pain
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How prior experience shapes placebo analgesia
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Testing two accounts of pain underestimation
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Chronic pain and sensory changes after augmentation mammoplasty: Long term effects of preincisional administration of methylprednisolone
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Drosophila models pioneer a new approach to drug discovery for Parkinson's disease
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Mechanisms Underlying Autoimmune Uveitis
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Systemic lupus erythematosus: From disease pathogenesis to therapy
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Immunopathological mechanisms in multiple sclerosis
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Mechanisms underlying type 1 diabetes and islet transplantation
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Enhancing the therapeutic index of radiation in multiple myeloma
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Underlying mechanisms of hematologic malignancies revealed by gene expression profiling
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Gastrointestinal signalling peptides in obesity
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The impact of interferon-β treatment on the blood–brain barrier
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Hit discovery and hit-to-lead approaches
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Targeting atypical trypanosomatid DNA topoisomerase I
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Modulating TNF-α signaling with natural products
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Can we estimate the accuracy of ADME–Tox predictions?
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Physical therapy and active exercises – An adequate treatment for prevention of late whiplash syndrome?: Randomized controlled trial in 200 patients
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Automated medicinal chemistry
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Informatics solutions for high-throughput proteomics
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Chemoproteomics-driven drug discovery: addressing high attrition rates
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Chondrocyte genomics: implications for disease modification in osteoarthritis
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Blood–brain barrier genomics and proteomics: elucidating phenotype, identifying disease targets and enabling brain drug delivery
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Clearance of amyloid-beta in Alzheimer's disease: progress, problems and perspectives
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Unpleasant odors increase pain processing in a patient with neuropathic pain: Psychophysical and fMRI investigation
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Downregulation of spinal glutamate transporter EAAC1 followingnerve injury is regulated by central glucocorticoid receptors in rats
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Acute low back pain: pain-related fear and pain catastrophizing influence physical performance and perceived disability
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The role of developmental factors in predicting young children's use of a self-report scale for pain
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Mechanisms of placebo analgesia: rACC recruitment of a subcortical antinociceptive network
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