Development of exosome-encapsulated paclitaxel to overcome MDR in cancer cells

Exosomes released by autologous macrophages were loaded with paclitaxel (PTX) upon ultrasound treatment. The obtained formulation (exoPTX) showed a high loading capacity, sustained drug release, profound ability to accumulate in resistant cancer cells, and increased cytotoxicity compared to PTX in vitro and in vivo.110