کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10461416 | 924491 | 2013 | 23 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Gene environment interaction studies in depression and suicidal behavior: An update
ترجمه فارسی عنوان
مطالعات متقابل محیط ژن در افسردگی و رفتار خودکشی: به روز رسانی
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کلمات کلیدی
CRHACECOMTCNR1Crhr1ABCG1Avpr1bCRHR2CRHBPBDNF - BDNF یا فاکتور نورونزایی مشتقشده از مغز Angiotensin-converting enzyme - آنژیوتانسین تبدیل آنزیمApoe - آپوBrain-derived neurotrophic factor - فاکتور نوروتروفی مشتق شده از مغزcorticotrophin-releasing hormone - هورمون آزاد کننده کورتیکوتروپینCannabinoid receptor 1 - گیرنده کانابینوئید 1
موضوعات مرتبط
علوم زیستی و بیوفناوری
علم عصب شناسی
علوم اعصاب رفتاری
چکیده انگلیسی
Increasing evidence supports the involvement of both heritable and environmental risk factors in major depression (MD) and suicidal behavior (SB). Studies investigating gene-environment interaction (GÂ ÃÂ E) may be useful for elucidating the role of biological mechanisms in the risk for mental disorders. In the present paper, we review the literature regarding the interaction between genes modulating brain functions and stressful life events in the etiology of MD and SB and discuss their potential added benefit compared to genetic studies only. Within the context of GÂ ÃÂ E investigation, thus far, only a few reliable results have been obtained, although some genes have consistently shown interactive effects with environmental risk in MD and, to a lesser extent, in SB. Further investigation is required to disentangle the direct and mediated effects that are common or specific to MD and SB. Since traditional GÂ ÃÂ E studies overall suffer from important methodological limitations, further effort is required to develop novel methodological strategies with an interdisciplinary approach.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Neuroscience & Biobehavioral Reviews - Volume 37, Issue 10, Part 1, December 2013, Pages 2375-2397
Journal: Neuroscience & Biobehavioral Reviews - Volume 37, Issue 10, Part 1, December 2013, Pages 2375-2397
نویسندگان
Laura Mandelli, Alessandro Serretti,