Curcumin ameliorates methylglyoxal-induced alterations of cellular morphology and hyperpermeability in human umbilical vein endothelial cells

► MGO induces the alteration of intracellular junction, cytoskeleton rearrangement, and permeability in HUVEC cells. ► Curcumin ameliorates MGO-induced alterations of cellular morphology and hyperpermeability in HUVECs cells. ► Curcumin is a potential protective agent against MGO-induced endothelial dysfunction.