Dose-dependent immunomodulatory effects of 10-hydroxy-2-decenoic acid on human monocyte-derived dendritic cells

► 10-HDA exerts different immunomodulatory activities, which are dose dependent. ► High doses of 10-HDA inhibited maturation and function of human MoDC. ► Low doses of 10-HDA acted stimulatory on MoDCs, favoring the Th1 immune response.