Morphology and protein content of hepatocytes in type I diabetic rats submitted to physical exercises

► This study reports structural and biochemical changes of diabetes and exercise. ► Regions of intense cytoplasmic basophilia were observed in control subjects. ► Mitochondria practically filled the whole cytosol in diabetic subjects. ► The lower quantity of RER in sedentary diabetics suggests lower protein production. ► It is evident the need for the combined application of a distinct form of treatment.