کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10672885 | 1010154 | 2019 | 29 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Direct investigation of charge transfer in neurons by electrostatic force microscopy
ترجمه فارسی عنوان
بررسی مستقیم انتقال بار در نورون توسط میکروسکوپ نیروی الکترواستاتیک
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
مهندسی مواد
فناوری نانو (نانو تکنولوژی)
چکیده انگلیسی
Charge transfer plays fundamental roles in information transmission in cells, especially in neurons. To date, direct observation of charge propagation in neurons at nanometer level has not been achieved yet. Herein, a combined charge injection and Electrostatic Force Microscopy (EFM) detection approach is applied to directly study charge propagation and distribution at nanometer resolution in spines and synapses of hippocampal neurons. Charge density, charge mobility and membrane potential in neural signal transmission process through the spines of axons and dendrites of hippocampal neurons were investigated quantitatively. Postsynaptic densities (PSD) in spines of axons and dendrites were revealed and studied. The methods and results from present work provide insights into physiological activities and processes related with electrical properties in nervous system and other biological samples.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Ultramicroscopy - Volume 196, January 2019, Pages 24-32
Journal: Ultramicroscopy - Volume 196, January 2019, Pages 24-32
نویسندگان
Weidong Zhao, Wei Cui, Shujun Xu, Yuanyuan Wang, Ke Zhang, Deyu Wang, Ling-Zhi Cheong, Flemming Besenbacher, Cai Shen,