کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10738554 | 1046714 | 2011 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury
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کلمات کلیدی
nuclear factor erythroid-2 related factor 2iOpMCP-1iNOSILMICAM-1COX-2HO-1Heme oxygenase-1Nrf2NQO1GCLCGCLMIL-6LPSNAD(P)H dehydrogenase, quinone 1CDDO-Me - CDDO-منI/R - I / RROS - ROSinflammation - التهاب( توروم) ischemia–reperfusion - ایسکمی-رپرفیوژنinterleukin-6 - اینترلوکین ۶Triterpenoids - تریترپروئیدtumor necrosis factor-α - تومور نکروز عامل αApoptosis - خزان یاختهایdihydroethidium - دی هیدروتیدیمinducible nitric oxide synthase - سنتاز اکسید نیتریک القاییCytokines - سیتوکین هاCyclooxygenase-2 - سیکلوکوکسیژناز2Retina - شبکیهNF-E2-related factor 2 - عامل NF-E2 2internal limiting membrane - غشای محدود کننده داخلیTNF-α - فاکتور نکروز توموری آلفاIntraocular pressure - فشار داخل چشمlipopolysaccharide - لیپوپلی ساکاریدglutamate-cysteine ligase, modifier subunit - لیگاز کلسترول گلوتامات، واحدهای اصلاح کنندهglutamate-cysteine ligase, catalytic subunit - لیگاز گلوتامات سیستئین، واحد کاتالیزوریKnockout mice - موش نابود شدهintercellular adhesion molecule-1 - مولکول چسبندگی بین سلولی -1DHE - وMonocyte chemotactic protein-1 - پروتئین chemotactic monocyte-1Reactive oxygen species - گونههای فعال اکسیژن
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
سالمندی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury Nrf2 has a protective role against neuronal and capillary degeneration in retinal ischemia-reperfusion injury](/preview/png/10738554.png)
چکیده انگلیسی
Retinal ischemia-reperfusion (I/R) involves an extensive increase in reactive oxygen species as well as proinflammatory changes that result in significant histopathologic damage, including neuronal and vascular degeneration. Nrf2 has a well-known cytoprotective role in many tissues, but its protective function in the retina is unclear. We investigated the possible role of Nrf2 as a protective mechanism in retinal ischemia-reperfusion injury using Nrf2â/â mice. I/R resulted in an increase in retinal levels of superoxide and proinflammatory mediators, as well as leukocyte infiltration of the retina and vitreous, in Nrf2+/+ mice. These effects were greatly accentuated in Nrf2â/â mice. With regard to histopathologic damage, Nrf2â/â mice exhibited loss of cells in the ganglion cell layer and markedly accentuated retinal capillary degeneration, as compared to wild-type. Treatment with the Nrf2 activator CDDO-Me increased antioxidant gene expression and normalized I/R-induced superoxide in the retina in wild-type but not Nrf2â/â mice. CDDO-Me treatment abrogated retinal capillary degeneration induced by I/R in wild-type but not Nrf2â/â mice. These studies indicate that Nrf2 is an important cytoprotective mechanism in the retina in response to ischemia-reperfusion injury and suggest that pharmacologic induction of Nrf2 could be a new therapeutic strategy for retinal ischemia-reperfusion and other retinal diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Free Radical Biology and Medicine - Volume 51, Issue 1, 1 July 2011, Pages 216-224
Journal: Free Radical Biology and Medicine - Volume 51, Issue 1, 1 July 2011, Pages 216-224
نویسندگان
Yanhong Wei, Junsong Gong, Takeshi Yoshida, Charles G. Eberhart, Zhenhua Xu, Ponvijay Kombairaju, Michael B. Sporn, James T. Handa, Elia J. Duh,