Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells

► RNA interference GPC3 induces apoptosis in human hepatocellular carcinoma cell. ► Silencing GPC3 resulted in the release of cytochrome c and activation of caspase-3. ► GPC3 modulates the Bax/Bcl-2/cytochrome c/caspase-3 apoptotic signaling pathway. ► Knockdown of GPC3 is a novel approach to HCC treatment.