Cbl-b-dependent degradation of FLIPL is involved in ATO-induced autophagy in leukemic K562 and gastric cancer cells

► FLIPL is a critical regulator of ATO-induced autophagy in K562 and MGC803 cells. ► Degradation of FLIPL protein by ATO is mediated through the ubiquitin-proteasome pathway. ► Cbl-b is involved in ATO-induced ubiquitination of FLIPL in K562 and MGC803 cells.