کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10899575 | 1084396 | 2015 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Piperine inhibits the growth and motility of triple-negative breast cancer cells
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
DIOC6XenograftCDKTNBCIAPHRPHER2mAbPiperineGSH3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide - 3- (4،5-dimethylthiazol-2-yl) -2،5-difenyltetrazolium bromideMTT - MTTROS - ROSMonoclonal antibody - آنتی بادی مونوکلونالApoptosis - خزان یاختهایBreast cancer - سرطان پستانTriple-negative breast cancer - سرطان پستان سه گانه منفیMetastasis - متاستاز inhibitor of apoptosis protein - مهار کننده پروتئین آپوپتوزیسAntibody - پادتَن یا آنتیبادیHorseradish peroxidase - پراکسیداز هوررادیشPropidium iodide - پروتئین یدیدreduced glutathione - کاهش گلوتاتیونcyclin-dependent kinase - کییناز وابسته به سیکلینReactive oxygen species - گونههای فعال اکسیژنHuman epidermal growth factor receptor 2 - گیرنده عامل فاکتور رشد اپیدرمی انسان 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Piperine, an alkaloid from black pepper, is reported to have anticancer activities. In this study, we investigated the effect of piperine on the growth and motility of triple-negative breast cancer (TNBC) cells. Piperine inhibited the in vitro growth of TNBC cells, as well as hormone-dependent breast cancer cells, without affecting normal mammary epithelial cell growth. Exposure to piperine decreased the percentage of TNBC cells in the G2 phase of the cell cycle. In addition, G1- and G2-associated protein expression was decreased and p21Waf1/Cip1 expression was increased in piperine-treated TNBC cells. Piperine also inhibited survival-promoting Akt activation in TNBC cells and caused caspase-dependent apoptosis via the mitochondrial pathway. Interestingly, combined treatment with piperine and γ radiation was more cytotoxic for TNBC cells than γ radiation alone. The in vitro migration of piperine-treated TNBC cells was impaired and expression of matrix metalloproteinase-2 and -9 mRNA was decreased, suggesting an antimetastatic effect by piperine. Finally, intratumoral administration of piperine inhibited the growth of TNBC xenografts in immune-deficient mice. Taken together, these findings suggest that piperine may be useful in the treatment of TNBC.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cancer Letters - Volume 357, Issue 1, 1 February 2015, Pages 129-140
Journal: Cancer Letters - Volume 357, Issue 1, 1 February 2015, Pages 129-140
نویسندگان
Anna L. Greenshields, Carolyn D. Doucette, Kimberly M. Sutton, Laurence Madera, Henry Annan, Paul B. Yaffe, Allison F. Knickle, Zhongmin Dong, David W. Hoskin,