کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10914532 | 1088792 | 2016 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Serum N-glycan analysis in breast cancer patients - Relation to tumour biology and clinical outcome
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کلمات کلیدی
mRNAUPLCTTGESLex2ABTemporal Temperature Gradient Gel Electrophoresis2-aminobenzamide - 2-آمینوبنزامیدsialyl Lewis X - sialyl لوئیس ایکسGene expression - بیان ژنBreast cancer - سرطان پستانultra performance liquid chromatography - کروماتوگرافی مایع با عملکرد فوق العادهhigh performance liquid chromatography - کروماتوگرافی مایع با کارایی بالاHPLC - کروماتوگرافی مایعی کارا
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
تحقیقات سرطان
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Glycosylation and related processes play important roles in cancer development and progression, including metastasis. Several studies have shown that N-glycans have potential diagnostic value as cancer serum biomarkers. We have explored the significance of the abundance of particular serum N-glycan structures as important features of breast tumour biology by studying the serum glycome and tumour transcriptome (mRNA and miRNA) of 104 breast cancer patients. Integration of these types of molecular data allows us to study the relationship between serum glycans and transcripts representing functional pathways, such as metabolic pathways or DNA damage response. We identified tri antennary trigalactosylated trisialylated glycans in serum as being associated with lower levels of tumour transcripts involved in focal adhesion and integrin-mediated cell adhesion. These glycan structures were also linked to poor prognosis in patients with ER negative tumours. High abundance of simple monoantennary glycan structures were associated with increased survival, particularly in the basal-like subgroup. The presence of circulating tumour cells was found to be significantly associated with several serum glycome structures like bi and triantennary, di- and trigalactosylated, di- and trisialylated. The link between tumour miRNA expression levels and N-glycan production is also examined.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Oncology - Volume 10, Issue 1, January 2016, Pages 59-72
Journal: Molecular Oncology - Volume 10, Issue 1, January 2016, Pages 59-72
نویسندگان
Vilde D. Haakensen, Israel Steinfeld, Radka Saldova, Akram Asadi Shehni, Ilona Kifer, Bjørn Naume, Pauline M. Rudd, Anne-Lise Børresen-Dale, Zohar Yakhini,