Local dose-effect relations for lung perfusion post stereotactic body radiotherapy

The relation between local dose and perfusion reduction in patients treated with SBRT can be modeled by a 3-parameter logistic model. This demonstrated relationship 4-months post-SBRT approaches a plateau for doses >100 Gy, where 90% of the maximum lung-perfusion reduction is observed at NTD = 78 Gy. A further perfusion reduction compared to 4-months post-SBRT was observed fifteen months post-SBRT.