کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934255 | 1093887 | 2005 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Inactivation of tensin3 in mice results in growth retardation and postnatal lethality
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کلمات کلیدی
ECMEGFRSRSPTBSH2Silver–Russell syndromeTensin - تنسینGrowth plates - صفحات رشدGrowth retardation - عقب ماندگی رشدFab - فابphosphotyrosine-binding - فسفاتیزین اتصالExtracellular matrix - ماتریکس خارج سلولیSrc Homology 2 - همبستگی Src 2Focal adhesion - چسبندگی کانونیEpidermal growth factor receptor - گیرنده فاکتور رشد اپیدرمال
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
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چکیده انگلیسی
Tensin family is a group of focal adhesion proteins that interact with integrins, actin, and phosphotyrosine-containing proteins. To explore the in vivo functions of a new member of the family, tensin3, we have generated mutant mice with a disrupted tensin3 gene. Inactivation of tensin3 resulted in growth retardation and postnatal lethality in one third of the homozygous mutants. Histological analysis of those mutants showed incomplete development of the small intestine, lung, and bone. Villus formation in the small intestine was affected and cells migrated slower in the runt mutants. Their lungs also displayed enlarged air space suggesting defects in alveogenesis. In addition, the resting zone was thicker and fewer proliferating cells were present in the growth plates of tensin3â/â tibiae. These observations indicate that tensin3 is essential for normal development and functions of the small intestine, lung, and bone. These phenotypes of the runt tensin3â/â mice are similar to some clinical features of Silver-Russell syndrome (SRS) which is a genetically inherited defect. About 10% of SRS cases have been linked to abnormality in chromosome 7p11.2-13, where human tensin3 gene is located, suggesting a potential link between tensin3 and SRS.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 279, Issue 2, 15 March 2005, Pages 368-377
Journal: Developmental Biology - Volume 279, Issue 2, 15 March 2005, Pages 368-377
نویسندگان
Ming-Ko Chiang, Yi-Chun Liao, Yasuko Kuwabara, Su Hao Lo,