Keywords: همبستگی Src 2; APCs; antigen-presenting cells; DAMPs; danger-associated molecular patterns; DCs; Donor-derived dendritic cells; ET; endotoxin tolerance; FFA; free fatty acids; Gsdmd; gasdermin D; HDAC11; Histone deacetylase 11; HFD; high fat diet; HMGB1; high mobility g
مقالات ISI همبستگی Src 2 (ترجمه نشده)
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Keywords: همبستگی Src 2; AEX; anion exchange chromatography; CID; collision induced dissociation; DHB; 2,5-dihydroxybenzoic acid; ECD; electron capture dissociation; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; EGFRvIII; epidermal growth factor receptor v
Keywords: همبستگی Src 2; AD; Alzheimer's disease; ALD; X-linked adrenoleukodystrophy; ALDRP; adrenoleukodystrophy-related protein; ALDP; adrenoleukodystrophy protein; ALS; amyotrophic lateral sclerosis; ATF-2; activating transcription factor 2; BBB; blood-brain barrier; AP-1; a
The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes
Keywords: همبستگی Src 2; Akt2-KO; Akt2 gene deletion; CHO; Chinese hamster ovary; DM; diabetes mellitus; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; ER; endoplasmic reticulum; GLUT4; glucose transporter type-4; GS; glycogen synthase; GSK-3; glycogen synt
SOCS-1 ameliorates smoke inhalation-induced acute lung injury through inhibition of ASK-1 activity and DISC formation
Keywords: همبستگی Src 2; SOCS-1; suppressor of cytokine signaling-1; ALI; acute lung injury; ARDS; acute respiratory distress syndrome; SAECs; small airway epithelial cells; GFP; green fluorescent protein; SH2; Src homology 2; ASK-1; apoptosis signal-regulating kinase-1; DISC; de
EphBs and ephrin-Bs: Trans-synaptic organizers of synapse development and function
Keywords: همبستگی Src 2; βGal; β-Galactosidase; Aβ; amyloid-β; Abl; Abelson murine leukemia viral oncogene homolog; AD; Alzheimer's disease; AMPAR; α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor; APP; amyloid precursor protein; BLA; basolateral amygdala; CaMKI
STAT3: The art of multi-tasking of metabolic and immune functions in obesity
Keywords: همبستگی Src 2; Signal transducer and activator of transcription 3; Obesity; Metabolism; Lipid; Immune; AgRP; Agouti-related peptide; AMPK; AMP-activated protein kinase; AOX; acyl-CoA oxidase; ARC; arcuate nucleus; ATGL; adipose triglyceride lipase; BAT; brown adipose ti
Molecular cloning, transcriptional profiling, and subcellular localization of signal transducer and activator of transcription 2 (STAT2) ortholog from rock bream, Oplegnathus fasciatus
Keywords: همبستگی Src 2; STAT2; signal transducer and activator of transcription 2; JAK; Janus kinase; IL-10; interleukin-10; TYK2; tyrosine kinase 2; IFN; interferon; ISGF3; IFN-stimulated gene factor 3; ISG; IFN-stimulated gene; CREB; cyclic AMP-response element-binding protein
TCR crosslinking promotes Crk adaptor protein binding to tyrosine-phosphorylated CD3ζ chain
Keywords: همبستگی Src 2; T cell activation; TCR/CD3 crosslinking; CD3ζ chain; Crk adaptor proteins; Tyrosine phosphorylation; Signal transduction; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Crk; CT10 (chicken tumor virus number 10) regulator of kinase; CrkL
Imaging flow cytometry and GST pulldown assays provide new insights into channel catfish leukocyte immune-type receptor-mediated phagocytic pathways
Keywords: همبستگی Src 2; Phagocytosis; Immunoregulatory receptors; Intracellular signaling; Actin polymerization machinery; Imaging flow cytometry; Innate immunity; Channel catfish; Leukocyte immune-type receptors; IpLITR; channel catfish leukocyte immune-type receptor; CYT; cyto
As human lung microvascular endothelia achieve confluence, src family kinases are activated, and tyrosine-phosphorylated p120 catenin physically couples NEU1 sialidase to CD31
Keywords: همبستگی Src 2; aa; amino acid; Ad; adenovirus; CD; cytoplasmic domain; EC; endothelial cell; ECL; enhanced chemiluminescence; EGFR; epidermal growth factor receptor; GST; glutathione S-transferase; HPMEC; human pulmonary microvascular endothelial cell; HRP; horseradish
Crk adaptor proteins regulate CD3ζ chain phosphorylation and TCR/CD3 down-modulation in activated T cells
Keywords: همبستگی Src 2; Abl; Abelson tyrosine kinase; C3G; Crk SH3 domain-binding guanine nucleotide-releasing factor; Cbl; Casitas B-lineage lymphoma; CD3ζY1-6F; CD3ζ mutant in which all 6 tyrosines were replaced by phenylalanine; Crk; CT10 (chicken tumor virus number 10) reg
Antagonizing STAT3 activation with benzo[b]thiophene 1, 1-dioxide based small molecules
Keywords: همبستگی Src 2; Antitumor agents; Aminobenzo[b]thiophene 1, 1-dioxides; Drug-likeness properties; STAT3 phosphorylation, Apoptosis; DMSO; dimethyl sulfoxide; AKT; a serine/threonine protein kinase; Erk; extracellular regulated kinase; rt; room temperature; MTT; 3-4,5-deh
Zebrafish STAT6 negatively regulates IFNÏ1 production by attenuating the kinase activity of TANK-binding kinase 1
Keywords: همبستگی Src 2; STAT6; Negative regulator; Interferon; TBK1; Zebrafish; CIP; calf intestinal phosphatase; CPE; cytopathic effect; EPC; epithelioma papulosum cyprini; GAS; interferon gamma activated sequence; IFN; interferon; IRF; IFN regulatory factor; IRF3; interferon r
The C1 domain of Vav3, a novel potential therapeutic target
Keywords: همبستگی Src 2; DAG; diacylglycerol; PKC; protein kinase C; GEF; guanine nucleotide exchange factor; PMA; phorbol 12-myristate 13-acetate; PDBu; phorbol 12,13-dibutyrate; CH domain; calponin homology domain; AD; acidic domain; DH; Dbl homology; PH; Pleckstrin homology; S
Molecular characterization and expression analysis of olive flounder (Paralichthys olivaceus) phospholipase C gamma 1 and gamma 2
Keywords: همبستگی Src 2; Phospholipase C gamma 1 (PLCG1); Phospholipase C gamma 2 (PLCG2); Olive flounder; Paralichthys olivaceus; cDNA cloning; mRNA expression; PLC; phosphoinositide-specific phospholipase C; PKC; protein kinase C; PLCG; phospholipase C gamma; SH2; Src homology
Direct coupling of the HER4 intracellular domain (4ICD) and STAT5A signaling is required to induce mammary epithelial cell differentiation
Keywords: همبستگی Src 2; 4ICD; HER4 intracellular domain; ATCC; American type culture collection; EGF; epidermal growth factor; EGFP; enhanced green fluorescent protein; EGFR; epidermal growth factor family; ERα; estrogen receptor alpha; FBS; fetal bovine serum; HEK; human embry
Pervanadate induces Mammalian Ste20 Kinase 3 (MST3) tyrosine phosphorylation but not activation
Keywords: همبستگی Src 2; Cys; cysteine; DMEM; Dulbecco's modified Eagle's medium; EGFR; epidermal growth factor receptor; GPCR; G protein-coupled receptor; HEK 293; human embryonic kidney 293; HPK1; hematopoietic progenitor kinase 1; MST; mammalian Ste20 kinase; MAP4K; MAP kinase
Immunoreceptors on neutrophils
Keywords: همبستگی Src 2; ADCC; antibody-dependent cellular cytotoxicity; ANCAs; anti-neutrophil autoantibodies; Btk; Bruton's tyrosine kinase; DAG; diacyl-glycerol; DAP12; DNAX activation protein of 12Â kDa; ERK; extracellular signal-regulated kinase; fMLP; N-Formylmethionine-leu
Microenvironment interactions and B-cell receptor signaling in Chronic Lymphocytic Leukemia: Implications for disease pathogenesis and treatment
Keywords: همبستگی Src 2; APRIL; a proliferation-inducing ligand; ATM; ataxia telangiectasia mutated; BAFF; B-cell activating factor; BAFFR; BAFF receptor; BAG6; BCL2-associated athanogene 6; BCMA; B-cell maturation antigen; BCL2; B-cell lymphoma 2; BCR; B cell receptor; bFGF; bas
ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing Zeta Associated Protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells
Keywords: همبستگی Src 2; Zeta Associated Protein-70 kD (ZAP-70); Syk family kinase; T-cell receptor; Signal transduction; Fluorescence resonance energy transfer (FRET); Biosensor; ZAP-70; Zeta Associated Protein 70 kD; SH2; Src homology 2; LAT; Linker for Activation of T cells; P
SHC1 sensitizes cancer cells to the 8-Cl-cAMP treatment
Keywords: همبستگی Src 2; 8-Chloro-cyclic AMP; SHC1; AMP-activated protein kinase; p38 MAP kinase; Cancer therapy; 8-Cl-cAMP; 8-Chloro-cyclic AMP; PKA; cyclic AMP-dependent protein kinase; AMPK; AMP-activated protein kinase; p38 MAPK; p38 mitogen-activated protein kinase; SHC1; Sr
SUV420H2 suppresses breast cancer cell invasion through down regulation of the SH2 domain-containing focal adhesion protein tensin-3
Keywords: همبستگی Src 2; mAb; monoclonal antibody; pAb; polyclonal antibody; H4K20me3; histone H4 at lysine 20 tri-methylation; H4K16ac; histone H4 at lysine 16 acetylation; H4K20me1; histone H4 at lysine 20 mono-methylation; H4K20me2; histone H4 at lysine 20 di-methylation; ChIP
Mutant huntingtin replaces Gab1 and interacts with C-terminal SH3 domain of growth factor receptor binding protein 2 (Grb2)
Keywords: همبستگی Src 2; HD; Huntington's disease; Htt; huntingtin; Grb2; growth factor receptor binding protein 2; Sos1; Son of Sevenless homolog 1; Gab1; Grb2 associated binding protein 1; SH2; Src homology 2; SH3; Src homology 3; N-SH3; N-terminal SH3 domain; C-SH3; C-terminal
The tyrosine phosphatase SHP2 is required for cell transformation by the receptor tyrosine kinase mutants FIP1L1-PDGFRα and PDGFRα D842V
Keywords: همبستگی Src 2; PDGFRA; PTPN11; SHP2; STAT5; Chronic eosinophilic leukemia; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; FLT3; Fms-like tyrosine kinase 3; FPα; FIP1L1-PDGFRα; GIST; gastrointestinal stromal tumors; MAPK; mitogen-activated protein
Deletion of the calmodulin-binding domain of Grb7 impairs cell attachment to the extracellular matrix and migration
Keywords: همبستگی Src 2; AEBSF; 4-(2-aminoethyl)-benzenesulfonyl fluoride; CaM; calmodulin; CaM-BD; calmodulin-binding domain; BPS; between PH and SH2; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbeccoâ²s modified Eagleâ²s medium; E-64; N-[N- (L-3-trans-carboxyirane-2-carbo
Two distinct mechanisms by which phospholipase C-γ1 mediates epidermal growth factor-induced keratinocyte migration and proliferation
Keywords: همبستگی Src 2; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Cai; intracellular calcium; NHK; normal human keratinocytes; PLC; phospholipase C; PLC-β1; phospholipase C-β1; PLC-γ1; phospholipase C-γ1; PLC-δ1; phospholipase C-δ1; PI3K; phosph
Biophysical studies with AICD-47 reveal unique binding behavior characteristic of an unfolded domain
Keywords: همبستگی Src 2; APP; amyloid precursor's protein; AICD; APP-intracellular C-terminal domain; AD; Alzheimer's disease; SH2; Src homology 2; PTR and pY; phosphorylated tyrosine; IUD; intrinsically unstructured domain; Grb2; growth factor receptor binding protein 2, TFE
Phosphosite conservation in single domain orthologs versus paralogs: A way to combine differential regulation with redundant core functions
Keywords: همبستگی Src 2; EST; expressed sequence tag; ADF; actin depolymerizing factor; EVH; Ena/VASP homology; PtdIns(4,5)P2; 1-(3-sn-Phosphatidyl)-d-myo-inositol 4,5-bis(phosphate); SH2; src homology 2; SH3; src homology 3; Single domain protein; Sequence conservation; Actin bi
Emerging role of p62/sequestosome-1 in the pathogenesis of Alzheimer's disease
Keywords: همبستگی Src 2; AD; Alzheimer's disease; AKT; protein kinase B; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor; aPKC; atypical protein kinase C; APP; amyloid-β precursor protein; ATG; AuTophaGy-related; BDNF; brain-derived neurotrophic factor; C/EBP; C
The application of modular protein domains in proteomics
Keywords: همبستگی Src 2; pTyr; phosphotyrosine; PTM; post-translational modification; MS; mass spectrometry; PSSM; position specific scoring matrix; SH2; Src homology 2; SH3; Src homology 3; WW; tryptophan tryptophan; PDZ; post synaptic density protein 95-disks large protein 4-zo
Identification and structural basis for a novel interaction between Vav2 and Arap3
Keywords: همبستگی Src 2; GEF; guanine nucleotide exchange factor; GAP; GTPase-activating protein; SH2; Src homology 2; pY; phosphotyrosine; PV; pervanadate; MD; molecular dynamics; Vav2; Arap3; SH2 domain; NMR; Protein-peptide interaction; Complex structure;
Channel catfish leukocyte immune-type receptor mediated inhibition of cellular cytotoxicity is facilitated by SHP-1-dependent and -independent mechanisms
Keywords: همبستگی Src 2; IpLITRs; Ictalurus punctatus leukocyte immune-type receptors; SH2; Src homology 2; SHP; Src homology 2 domain-containing cytoplasmic phosphatase; Csk; C-terminal Src kinase; ITAM; immune receptor tyrosine-based activation motif; SFK; Src-family protein ty
An adjacent arginine, and the phosphorylated tyrosine in the c-Met receptor target sequence, dictates the orientation of c-Cbl binding
Keywords: همبستگی Src 2; TKB; tyrosine kinase binding; SH2; Src homology 2; SPR; surface plasmon resonance; EGFR; epidermal growth factor receptor; Met; hepatocyte growth factor receptor; Cbl; casitas B-lineage lymphoma; c-Casitas B-lineage lymphoma tyrosine kinase binding domain
Oxidative stress, insulin signaling, and diabetes
Keywords: همبستگی Src 2; AGE; advanced glycated end product; CAP; c-Cbl-associated protein; DAG; diacylglycerol; eNOS; endothelial nitric oxide synthase; ERK; extracellular signal-regulated kinase; ETC; electron transport chain; GH; growth hormone; GLUT4; glucose transporter type
Several agents and pathways regulate lipolysis in adipocytes
Keywords: همبستگی Src 2; Lipolysis; Adipose tissue; Intracellular signalling pathways; Hormone-sensitive lipase; Adipose triglyceride lipase; Antilipolysis; ACTH; adrenocorticotrophin hormone; AdPLA; adipose-specific phospholipase A2; Ang II; angiotensin II; ANP; atrial natriuret
Non-T cell activation linker regulates ERK activation in Helicobacter pylori-infected epithelial cells
Keywords: همبستگی Src 2; TRAP; transmembrane adapter protein; NTAL; non-T cell activation linker; LIME; lymphocyte-specific protein tyrosine kinase (Lck)-interacting membrane protein; LAT; linker for activation of T cells; PAG; protein associated with glycosphingolipid-enriched m
A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally
Keywords: همبستگی Src 2; Allergy and inflammation; anaphylactic shock; degranulation; druglike compound; mast cells/basophils; tyrosine kinase; Syk; BMMC; Bone marrow-derived mast cell; C-13; Compound 13; ITAM; Immunoreceptor tyrosine-based activation motif; LAT; Linker for act
Role of water molecules for binding inhibitors in the SH2 domain of Grb2: A molecular dynamics study
Keywords: همبستگی Src 2; Grb2 SH2; Molecular dynamics; Solvent effects; Water bridging; Ligand binding; Drug design; EGF-R; epidermal growth factor receptor; Grb2; growth factor receptor bound protein 2; IC50; concentration required for 50% inhibition; MAPK; mitogen-activated pro
Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss
Keywords: همبستگی Src 2; M-CSF; macrophage colony-stimulating factor; CSF-1; colony-stimulating factor-1; M-CSFR; M-CSF receptor; CSF-1R; CSF-1 receptor; LPS; lipopolysaccharide; IFN; interferon; IL-1; interleukin-1; TNF; tumor necrosis factor; G-CSF; granulocyte-CSF; SH2; Src ho
Inactivation of tensin3 in mice results in growth retardation and postnatal lethality
Keywords: همبستگی Src 2; ECM; extracellular matrix; EGFR; epidermal growth factor receptor; FAB; focal adhesion binding; SH2; Src homology 2; PTB; phosphotyrosine-binding; SRS; Silver-Russell syndrome; Tensin; Focal adhesion; Growth retardation; Postnatal lethality; Alveogenesi
E3B1, a human homologue of the mouse gene product Abi-1, sensitizes activation of Rap1 in response to epidermal growth factor
Keywords: همبستگی Src 2; Abi-1; Abl-interactor-1; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GAP; GTPase-activating protein; GEFs; guanine nucleotide exchange factors; GST; glutathione-S-transferase; mAb; monoclonal antibody; pAb; polyclonal antibody; P
Stereoselective synthesis of new modified conformationally constrained l-tyrosine analogue with potential applications to SH2 domain ligands
Keywords: همبستگی Src 2; Src homology 2; l-Tyrosine; Mannich reaction;
Distinct Grb10 domain requirements for effects on glucose uptake and insulin signaling
Keywords: همبستگی Src 2; Grb10; growth factor receptor-binding protein 10; EGF; epidermal growth factor; SH2; Src homology 2; PH; pleckstrin homology; BPS; between PH and SH2; IGF-I; insulin-like growth factor-I; GIGYF; Grb10-interacting GYF protein; IRS; insulin receptor substra
Protein kinase structure and function analysis with chemical tools
Keywords: همبستگی Src 2; AANAT; serotonin N-acetyltransferase or arylalkylamine N-acetyltransferase; aPP; avian pancreatic polypeptide; CaMKII; Ca2+/calmodulin kinase II; CAT; chloramphenicol acetyltransferase; CHO; Chinese hamster ovary; Csk; C-terminal Src kinase; Fmoc; fluoren
Functional identification of kinases essential for T-cell activation through a genetic suppression screen
Keywords: همبستگی Src 2; GSE; genetic suppressor element; STE; homologs to yeast sterile7, sterile 11, and sterile 20 kinases; CAMK; calcium/calmodulin-dependent-like protein kinases; AGC; containing PAK, PKG, and PKC kinase families; CMGC; containing CDK, MAPK, GSK3, and CLK kin