کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
9142203 | 1163905 | 2005 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss
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کلمات کلیدی
SH2CSF-1 receptorgranulocyte-CSFTNFM-CSF receptorM-CSFRColony-stimulating factor-1LBP/BPICSF-1RCSF-1M-CSFIL-1LPSinterferon - اینترفرونIFN - اینترفرون هاinterleukin-1 - اینترلوکین-1Ovary - تخمدانReproduction - تولید مثل یا زادآوریG-CSF - فاکتور محرک کُلونی گرانولوسیتtumor necrosis factor - فاکتور نکروز تومورlipopolysaccharide - لیپوپلی ساکاریدTeleost fish - ماهی تلیوستmacrophage colony-stimulating factor - ماکروفاژ عامل کلونی تحریک کنندهSrc Homology 2 - همبستگی Src 2
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
زیست شناسی مولکولی
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss Molecular cloning and expression analysis of a macrophage-colony stimulating factor receptor-like gene from rainbow trout, Oncorhynchus mykiss](/preview/png/9142203.png)
چکیده انگلیسی
The M-CSF and its receptor (M-CSFR, CSF-1R or c-fms proto-oncogene) system were initially implicated as essential in mammals for normal monocyte development as well as for pregnancy. To allow a comparison with the M-CSF and M-CSFR system of an oviparous animal, we cloned a M-CSFR-like gene from rainbow trout (Oncorhynchus mykiss). The gene was cloned from a cDNA library of head kidney. It contained an open reading frame encoding 967 amino acids with a predicted size of 109Â kDa. The putative amino acid sequence of rainbow trout M-CSFR showed 54% amino acid identity to fugu (Takifugu rubripes) M-CSFR, 52% to zebrafish (Danio rerio) M-CSFR and 40% to mouse (Mus musculus) and human (Homo sapiens) M-CSFR. The M-CSFR-like gene was constitutively expressed in head kidney, kidney, intestine, spleen and blood. The gene was detected especially in the ovary of immature female rainbow trout. These results suggest that a M-CSFR-like receptor may be involved in female reproductive tracts even in an oviparous animal like fish.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Molecular Immunology - Volume 42, Issue 1, January 2005, Pages 1-8
Journal: Molecular Immunology - Volume 42, Issue 1, January 2005, Pages 1-8
نویسندگان
Teruko Honda, Takashi Nishizawa, Maya Uenobe, Chie Kohchi, Akashi Kuroda, Mitsuru Ototake, Teruyuki Nakanishi, Yuichi Yokomizo, Yukinori Takahashi, Hiroyuki Inagawa, Gen-Ichiro Soma,