Delayed post-conditioning reduces post-ischemic glutamate level and improves protein synthesis in brain

► Ischemia elevates blood and brain glutamate and tissue protein synthesis. ► Post-conditioning activates mechanisms to eliminate glutamate from brain and blood. ► This mechanism is activated promptly, reflecting early blood glutamate decreasing. ► Post-conditioning renews protein synthesis and contributes to glutamate reducing. ► Glutamate has a great potential in monitoring the effectiveness of therapy.