Involvement of glucocorticoid-mediated Zn2+ signaling in attenuation of hippocampal CA1 LTP by acute stress

► Clioquinol ameliorates stress-induced attenuation of CA1 LTP. ► Corticosterone increases Zn2+ release from zincergic neuron. ► Corticosterone also increases cytosolic Zn2+ by zincergic excitation. ► CaEDTA abolishes corticosterone-induced attenuation of CA1 LTP. ► Increase in cytosolic Zn2+ is involved in attenuation of CA1 LTP by stress.