کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1102837 953631 2009 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Matrix Metalloproteinases (MMP-2 and MMP-9) and Cyclooxygenase-2 (COX-2) Expressions in Vocal Fold Polyps
موضوعات مرتبط
علوم پزشکی و سلامت پزشکی و دندانپزشکی بیماری های گوش و جراحی پلاستیک صورت
پیش نمایش صفحه اول مقاله
Matrix Metalloproteinases (MMP-2 and MMP-9) and Cyclooxygenase-2 (COX-2) Expressions in Vocal Fold Polyps
چکیده انگلیسی

SummaryThe objective of this study was to investigate the roles of matrix metalloproteinases (MMP-2, MMP-9) and cyclooxygenase-2 (COX-2) in the pathogenesis of vocal fold polyps (VFPs). In this study, 20 VFPs and 8 normal vocal fold (VF) specimens were obtained from subjects undergoing surgery. Staining intensities were semiquantitatively assessed and statistically analyzed. Significant increases were observed in the expressions of MMP-2, MMP-9, and COX-2 in stromal spindle cells (P = 0.00) and vascular wall (P = 0.04, P = 0.00, P = 0.00) of VFPs compared with normal VFs. MMP-2 expression in surface epithelium basal cells (P = 0.00) of VFPs showed enhancement compared with normal vocal folds, whereas MMP-9 and COX-2 expressions showed no significant differences. Our study showed that gelatinases and COX-2 may play a role in the development of VFPs. This is the first study to document the expression of gelatinases and COX-2 in VFPs.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Voice - Volume 23, Issue 1, January 2009, Pages 29–33
نویسندگان
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