کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1193935 | 1492359 | 2008 | 6 صفحه PDF | دانلود رایگان |
Laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) was used to quantify and monitor the concentration of Pt along a single strand of hair from a patient who had been treated with cisplatin as cytostatic drug. The sensitivity of the analytical method developed could be increased by total ablation of the hair cross-section compared to partial ablation. A low-noise intensity ratio was obtained along the strand, while the blank was negligible. The variation of the Pt signal with reference to each cisplatin dose was clearly observed. Home-made standards consisting of Pt-enriched hair strands served as calibrators and sulphur (measuring 34S+) was used as the internal reference element. The correlation coefficient of the calibration curve for platinum was 0.9973 and the detection limit was 0.029 μg g−1. The rate of hair growth between doses was constant. The mean relative standard deviation (R.S.D.) for five replicates of single hair strands ranged from 15 to 22%. The maximum concentrations of Pt found along the hair strands were 26.9 ± 5.3, 14.7 ± 3.3, 20.9 ± 3.9 and 26.1 ± 3.8 μg g−1, which correspond to four treatment of cisplatin administered to the patient at 3-week intervals.
Journal: International Journal of Mass Spectrometry - Volume 272, Issue 1, 15 April 2008, Pages 57–62