کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1207243 | 1493713 | 2008 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Preparation and characterization of poly(l-phenylalanine) chiral stationary phases with varying peptide length
دانلود مقاله + سفارش ترجمه
دانلود مقاله ISI انگلیسی
رایگان برای ایرانیان
کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی آنالیزی یا شیمی تجزیه
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Three new chiral stationary phases with different lengths of l-phenylalanine peptide were prepared by solid-phase synthesis with tert-butoxycarbonyl (Boc)-l-phenylalanine on silica. The effect of phenylalanine peptide length on enantioselectivity was studied. The best separation of R/S-warfarin was achieved by the chiral stationary phase with intermediate peptide length. These stationary phases were found to exist mainly in α-helical conformation by using FT-IR spectra. The end-capping reagents for the N-terminus of the peptide were also evaluated.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Chromatography A - Volume 1208, Issues 1–2, 24 October 2008, Pages 242–245
Journal: Journal of Chromatography A - Volume 1208, Issues 1–2, 24 October 2008, Pages 242–245
نویسندگان
Kaname Ohyama, Kana Oyamada, Naoya Kishikawa, Yoshihito Ohba, Mitsuhiro Wada, Toshihide Maki, Kenichiro Nakashima, Naotaka Kuroda,