کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1244028 | 969679 | 2007 | 8 صفحه PDF | دانلود رایگان |
A liquid chromatography–tandem mass spectrometry method for the determination and confirmation of nine quinolones was optimised and validated according to Commission Decision 2002/657/EC. Analytes were extracted from veal muscle with water and extracts purified with 96-well plates Oasis HLB cartridges. Separation was carried out in a silica-based C18 column (50 mm × 2.1 mm) with mobile phases consisting of water/acetonitrile mixtures containing acetic acid. Linear calibration curves in the ranges 4–400 and 50–800 ng g−1, with correlation coefficients at least 0.995, were obtained for all the analytes. At concentration levels above 10 ng g−1, quantification errors were lower than 10% and repeatability and within-laboratory reproducibility standard deviations below 6% and 10%, respectively. Decision limits and detection capabilities are reported.
Journal: Talanta - Volume 72, Issue 1, 15 April 2007, Pages 269–276