کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1256537 | 971488 | 2007 | 4 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis and antitumor activity of heterocyclic acid ester derivatives of 20S-camptothecins
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موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی (عمومی)
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A series of heterocyclic acid esters of camptothecins as new compounds had been synthesized by acylation method, their in vitro and in vivo antitumor activities were evaluated. The cytotoxic results showed that 6 possessed the best efficacy on six human cancer cell lines in the six classes of CPTs’ derivatives. In vivo testing results indicated that 9 had better antitumor activity against mouse liver carcinoma H22 than topotecan.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Chinese Chemical Letters - Volume 18, Issue 11, November 2007, Pages 1335–1338
Journal: Chinese Chemical Letters - Volume 18, Issue 11, November 2007, Pages 1335–1338
نویسندگان
Di Zao Li, Yan Li, Xiao Guang Chen, Chen Gen Zhu, Jing Yang, Hong Yan Liu, Xian Dao Pan,