NiCl2(PCy3)2-catalyzed hydrodefluorination of fluoroarenes with LiAl(O-t-Bu)3H

A highly efficient and practical approach to the hydrodefluorination of CF bond in fluoroarenes in the presence of 5 mol% NiCl2(PCy3)2 with lithium tri-t-butoxyaluminium hydride (LiAl(O-t-Bu)3H) under mild conditions has been developed.

A highly efficient and practical NiCl2(PCy3)2-catalyzed hydrodefluorination of CF bond in fluoroarenes with lithium tri-t-butoxyaluminium hydride (LiAl(O-t-Bu)3H) was developed.Figure optionsDownload as PowerPoint slideHighlights
► The activation of CF bonds.
► The hydrodefluorination of fluoarenes.
► A cheap, easy to handle reducing agent, lithium tri-t-butoxyaluminium hydride (LiAl(O-t-Bu)3H).
► Using 5 mol% NiCl2(PCy3)2 as catalyst.