کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1314866 | 975989 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Synthesis of new β-trifluoromethyl containing GABA and β-fluoromethyl containing N-benzylpyrrolidinones
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کلمات کلیدی
موضوعات مرتبط
مهندسی و علوم پایه
شیمی
شیمی معدنی
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
A whole series of 3-(mono-, di-, trifluoro)methyl-substituted N-benzylpyrrolidinones 5a–c was synthesized by deoxyfluorination of corresponding 3-functionalized N-benzylpyrrolidinones. New β-trifluoromethyl containing GABA 4a was obtained in two alternative ways: by successive hydrolysis and hydrogenolysis of 3-trifluoromethyl N-benzylpyrrolidinone 5a and from trifluoroacetone as starting compound.
A series of 3-(mono-, di-, trifluoro)methyl containing N-benzylpyrrolidinones 5a–c was synthesized by deoxyfluorination reactions. New β-trifluoromethyl containing GABA 4a was obtained by two different ways.Figure optionsDownload as PowerPoint slide
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Fluorine Chemistry - Volume 131, Issue 2, February 2010, Pages 224–228
Journal: Journal of Fluorine Chemistry - Volume 131, Issue 2, February 2010, Pages 224–228
نویسندگان
Igor I. Gerus, Roman V. Mironets, Elena N. Shaitanova, Valery P. Kukhar,