کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1315029 | 976000 | 2010 | 4 صفحه PDF | دانلود رایگان |
Chlorotrifluoroethene is converted in situ to [F2CCFSiMe3]. The crude [F2CCFSiMe3] solution is reduced with lithium aluminum hydride to (HFCCFSiMe3), which (without isolation) is converted to (Z)-HFCCFSnBu3. Subsequent metallation and trapping of the vinyllithium reagent with Bu3SnCl gives (E)-Bu3SnCFCFSnBu3 in 73% overall yield. Only two isolation steps are required and the use of Me3SiCl and F2CCFCl provides a cheap, economical route to this useful synthon.
Chlorotrifluoroethene is converted in situ to [F2CCFSiMe3]. The crude [F2CCFSiMe3] solution is reduced with lithium aluminum hydride to (HFCCFSiMe3), which (without isolation) is converted to (Z)-HFCCFSnBu3. Subsequent metallation and trapping of the vinyllithium reagent with Bu3SnCl gives (E)-Bu3SnCFCFSnBu3 in 73% overall yield. Only two isolation steps are required and the use of Me3SiCl and F2CCFCl provides a cheap, economical route to this useful synthon.Figure optionsDownload as PowerPoint slide
Journal: Journal of Fluorine Chemistry - Volume 131, Issue 11, November 2010, Pages 1082–1085