کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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1406084 | 1501834 | 2010 | 7 صفحه PDF | دانلود رایگان |
(R, S)-1-(2′,3′-Dibenzoyloxypropyl)-5,6-dihydrothymine (2) was synthesized from (R, S)-1-(2′,3′-dihydroxypropyl)-5,6-dihydrothymine and its structure has been analyzed by X-ray diffraction, NMR and FTIR spectroscopic methods. The molecular structure and supramolecular assembling of 2 is compared with the structure of its dimesyloxypropyl analogue (1). Compound 1 crystallizes as cocrystal of two diastereoisomers, while 2 crystallizes as a racemic mixture. Main hydrogen-bonded motif in both compounds is dimer formed by pair of NH···O(C) hydrogen bonds, which are further linked by CH···O hydrogen bonds. Phenyl rings of dibenzoyl-dihydropyrimidine moieties of 2 participate also in supramolecular aggregation via three CH···π interactions. Hydrogen bonding as driving force of 2 self-assembly was proving by the NMR and FTIR spectroscopy.
Journal: Journal of Molecular Structure - Volume 980, Issues 1–3, 10 September 2010, Pages 156–162