کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1407082 | 1501888 | 2008 | 5 صفحه PDF | دانلود رایگان |
Four bile acid-arene conjugates, 1,4-bis[dimethyl(3α,7α,12α-trihydroxy-5β-cholan-24-amidoethyl)ammoniomethyl]benzene dibromide (1), 1,3,5-tris[dimethyl(3α,7α,12α-trihydroxy-5β-cholan-24-amidoethyl)ammoniomethyl]benzene tribromide (2), bis{4-[dimethyl(3α,7α,12α-trihydroxy-5β-cholan-24-amidoethyl)ammoniomethyl]phenyl}diazene dibromide (3), and bis{4-[dimethyl(3α-hydroxy-5β-cholan-24-amidoethyl)ammoniomethyl]phenyl}diazene dibromide (4), have been synthesized in good yields, and their structures have been characterized by 1H, 13C, 13C DEPT-135, PFG 1H, 13C HMQC, PFG 1H, 13C HMBC, and PFG 1H, 15N HMBC NMR spectra. Their molecular weights and elemental compositions have been determined by ESI-TOF mass spectrometry and elemental analyses. Trans to cis isomerization of azobenzene derivatives 3 and 4 have also been studied. It was found that by increasing the hydrophobicity of bile acid moiety (from cholyl to lithocholyl) the trans to cis photoinduced isomerization tendency is increased in a protic solvent.
Journal: Journal of Molecular Structure - Volume 875, Issues 1–3, 17 March 2008, Pages 63–67