کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
1409308 1501797 2012 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Ionic liquid catalyzed one-pot multi-component synthesis, characterization and antibacterial activity of novel chromeno[2,3-d]pyrimidin-8-amine derivatives
موضوعات مرتبط
مهندسی و علوم پایه شیمی شیمی آلی
پیش نمایش صفحه اول مقاله
Ionic liquid catalyzed one-pot multi-component synthesis, characterization and antibacterial activity of novel chromeno[2,3-d]pyrimidin-8-amine derivatives
چکیده انگلیسی

An efficient, simple and convenient method for the one-pot multi-component synthesis of novel chromeno[2,3-d]pyrimidin-8-amine derivatives has been accomplished by starting from α-naphthol, aryl aldehydes, malononitrile and NH4Cl. The reaction has been catalyzed by 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 ionic liquid. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. The structure of compound 4a was confirmed by single-crystal X-ray diffraction. All the synthesized compounds were evaluated for their in vitro antibacterial activity.


► Chromenopyrimidines were synthesized with an aid of ionic liquid catalyst.
► Synthesized compounds were characterized by elemental analysis and spectroscopy.
► Compound 4a was confirmed by single crystal X-ray diffraction.
► Amino (NH2) group has not involved in any hydrogen bonding.
► Synthesized compounds were evaluated for their in vitro antibacterial activity.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Journal of Molecular Structure - Volume 1017, 13 June 2012, Pages 60–64
نویسندگان
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