کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
1409308 | 1501797 | 2012 | 5 صفحه PDF | دانلود رایگان |
An efficient, simple and convenient method for the one-pot multi-component synthesis of novel chromeno[2,3-d]pyrimidin-8-amine derivatives has been accomplished by starting from α-naphthol, aryl aldehydes, malononitrile and NH4Cl. The reaction has been catalyzed by 1-butyl-3-methylimidazolium tetrafluoroborate [bmim]BF4 ionic liquid. The newly synthesized compounds were characterized by IR, 1H NMR, 13C NMR, mass spectra, and elemental analysis. The structure of compound 4a was confirmed by single-crystal X-ray diffraction. All the synthesized compounds were evaluated for their in vitro antibacterial activity.
► Chromenopyrimidines were synthesized with an aid of ionic liquid catalyst.
► Synthesized compounds were characterized by elemental analysis and spectroscopy.
► Compound 4a was confirmed by single crystal X-ray diffraction.
► Amino (NH2) group has not involved in any hydrogen bonding.
► Synthesized compounds were evaluated for their in vitro antibacterial activity.
Journal: Journal of Molecular Structure - Volume 1017, 13 June 2012, Pages 60–64